Did you hear? Metformin as an anti-aging drug.
 

Ran across this today.



Or, I dunno, maybe EAT RIGHT?

A low carb diet has a known anti-aging effect too... reduces free radicals, inflammation, and AGEs.

And so metformin is not without its side effects, I understand.

How do side effects like heartburn, stomach pain, nausea, vomiting, bloating, gas, diarrhea, constipation & headaches make you look younger?

Maybe one on metformin looks like an infant with colic?

ROFL


-----maybe like many meds, the dose is altered, often the timing or reduce the dosing......

drugs deplete your mg.

The mere thought is an admission that blood sugar control is a part of the health picture!

. . . and in today's world, there seems to be a preference to control things like high blood sugar with a prescription . . . a sad distortion of how we should be viewing health.

Gave The Dental Diet to a family member to read-- a dentist--- the conversation was only that fructose is the culprit for our health problems, notably obesity{thud}


I feel like I am talking to dinosaurs--- people behind the times, and not up to speed....

Hmm, Merformin ..... or fasting??? FASTING is MY first choice.

Mind you, I can stack my supplement bill up against anyone here: and I would probably win. This is the latest list in what has been a health struggle that is getting into its seventh year:

• multigram doses of Omega 3 fish oil - to heal my brain
• multigram doses of pregnenolone - to replace hormones, neurotransmitters, and lower cortisol
• theraputic niacin, 3k a day with B complex & C - to lower my anxiety
• Vitamin D3 with K2 - to support immune system & all other good things
• chelated magnesium - for mental health and balance electrolytes
• kelp - all the micronutrients
• black cherry - because gout runs in the family and my arthritis is in my thumbs

I believe in nutrients. After years of bad eating, and current issues which probably mean I need help, I don't see how even the most calibrated eating will meet my extreme needs.

And unless you are under forty and live naked on the equator, it's likely you need the D & K.

Supplements make a lot of sense when keeping in mind that the very essential minerals we need like magnesium have been leached from the soil. It's particularly challenging for vegans and vegetarians because today, meat is the most nutrient dense and complete source of food.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772929/
This is just an example of the first thing that popped up when I googled "metformin" with "cancer." There are some real effects going on with metformin in the anti-cancer and anti-aging fields, likely related to the above mechanisms. Would I take metformin just to slow aging without another medical reason to do so? Maybe not. But for those who need it anyway for other medical conditions, nice side effect benefit?

I'm ok with blaming insulin, but I'm not ok with blaming IGF-1. To wit, IGF-1 is stimulated by growth hormone and GH is absolutely essential for maintaining good health, never mind a child's growth.

So, how does metformin work? It activates insulin receptors. In doing so, this means insulin is now more potent. This is probably good at the liver, where insulin is degraded, hence the claimed drop of insulin in peripheral tissue. But everywhere else, it just makes things worse, especially at the fat tissue, especially when there's already too much insulin floating around, ya?

Cancer and insulin, it's a pair. Well, if we activate the insulin receptors, and if that makes insulin more potent, that's a problem.

Metformin and longevity, and of course insulin, it's a trio. From c. elegans research by (I forget her name), we know insulin (and glucose) is certainly involved at least mechanistically with longevity. The more insulin, the shorter those worms lived. The more metformin, the more potent insulin, you do the math.

Apparently, those who take metformin suffer fewer all-causes diseases than those who don't take metformin. Problem with this comparison, where's the healthy people that don't take metformin? Jeebus, where's the healthy people that take metformin, huh? Cuz metformin is prescribed only to sick people.

How convenient. A drug that's already been paid for all of a sudden is a cure all. Studies galore. But who paid for these studies? Who is paying the studiers?

The Corruption of Evidence Based Medicine – Killing for Profit 4-9-2018

Yes, very suspect.

I'd rather use fasting than metformin. As I know many on this forum would, whereas those that want to pop a pill will ask for metformin, and happily believe all will be well.

Rapamycin [Everolimus, Afinitor or Sirolimus] is another drug gaining traction among the "healthspan" crowd. Inhibition of mTOR, the molecular target of everolimus, extends the lifespan of model organisms including mice, and mTOR inhibition has been suggested as an anti-aging therapy. A study is under way in Seattle to see if rapamycin extends the lives of pet dogs.

The side effects will curl your hair -- I would rather die early.

https://www.technologyreview.com/s/...en-waiting-for/