Wuzzy
Sun, Jan-19-03, 23:57
A follow up on a previous problem, sorry if unintelligble:
Was puzzled because:
1)FFA cycles in enormous quantities. (yes fat gets
re-esterified and stored even when theres little insulin
during fasting - its well known and called the FFA/TAG
cycle. >200g cycle during the day whereas only 80g burned,
insulin temporarily "evaporates" the circulation though but
it has a small half life of a few hours so its only meant to
do this during postprandial)
2)VLDL also exists in the blood in enormous quantities. it is
made mostly from FFA (>75%).
yet
3)VLDL is minor as a fuel substrate. Only 5% of fats
make it into
VLDL.
I have reconciled 2 with 4 (ie that small amounts of VLDL 5%
come from adipose yet it is in high concentrations in the
blood) by arguing that FFA has a half-life of a few minutes
whereas VLDL has a half life of many hours (~3hrs).
That would explain it, right?
Was puzzled because:
1)FFA cycles in enormous quantities. (yes fat gets
re-esterified and stored even when theres little insulin
during fasting - its well known and called the FFA/TAG
cycle. >200g cycle during the day whereas only 80g burned,
insulin temporarily "evaporates" the circulation though but
it has a small half life of a few hours so its only meant to
do this during postprandial)
2)VLDL also exists in the blood in enormous quantities. it is
made mostly from FFA (>75%).
yet
3)VLDL is minor as a fuel substrate. Only 5% of fats
make it into
VLDL.
I have reconciled 2 with 4 (ie that small amounts of VLDL 5%
come from adipose yet it is in high concentrations in the
blood) by arguing that FFA has a half-life of a few minutes
whereas VLDL has a half life of many hours (~3hrs).
That would explain it, right?