Doe
Mon, Oct-28-02, 20:58
So since tannin changes iron III to iron II .. and it is an
iron chelator ..? So the brain either has too few iron binders
.. or it has too much iron .. ?
: J Neurochem 2002 Sep;82(5):1137-47 Related Articles, Links
Iron (III) induces aggregation of hyperphosphorylated tau and
its reduction to iron (II) reverses the aggregation:
implications in the formation of neurofibrillary tangles of
Alzheimer's disease.
Yamamoto A, Shin RW, Hasegawa K, Naiki H, Sato H, Yoshimasu F,
Kitamoto T.
Department of Neurological Science, Tohoku University School
of Medicine, Sendai, Japan.
Iron as well as aluminum is reported to accumulate in neurons
with neurofibrillary tangles (NFTs) of Alzheimer's disease
(AD) brain. Previously we demonstrated that aluminum (III)
shows phosphate-dependent binding with hyperphosphorylated tau
(PHFtau), the major constituent of NFTs, thereby inducing
aggregation of PHFtau. Herein we report that iron (III) can
also induce aggregation of soluble PHFtau. Importantly, for
the aggregation of PHFtau to occur, iron in the oxidized state
(III) is essential since iron in the reduced state (II) lacks
such ability. Furthermore, iron (III)-induced aggregation is
reversed by reducing iron (III) to iron (II). Thus the
iron-participating aggregation is mediated not only by tau
phosphorylation but also by the transition of iron between
reduced (II) and oxidized (III) states. Further incubation of
insoluble PHFtau aggregates isolated from AD brain with
reducing agents produced liberation of solubilized PHFtau and
iron (II), indicating that PHFtau in association with iron
(III) constitutes the insoluble pool of PHFtau. These results
indicate that iron might play a role in the aggregation of
PHFtau leading to the formation of NFTs in AD brain.
PMID: 12358761 [PubMed - indexed for MEDLINE]
Who loves ya. Tom Jesus was a vegetarian!
http://jesuswasavegetarian.7h.com
Jesus was a vegetarian! http://www.nucleus.com/watchman Moses
was a mystic! http://www.nucleus.com/watchman/light.html
iron chelator ..? So the brain either has too few iron binders
.. or it has too much iron .. ?
: J Neurochem 2002 Sep;82(5):1137-47 Related Articles, Links
Iron (III) induces aggregation of hyperphosphorylated tau and
its reduction to iron (II) reverses the aggregation:
implications in the formation of neurofibrillary tangles of
Alzheimer's disease.
Yamamoto A, Shin RW, Hasegawa K, Naiki H, Sato H, Yoshimasu F,
Kitamoto T.
Department of Neurological Science, Tohoku University School
of Medicine, Sendai, Japan.
Iron as well as aluminum is reported to accumulate in neurons
with neurofibrillary tangles (NFTs) of Alzheimer's disease
(AD) brain. Previously we demonstrated that aluminum (III)
shows phosphate-dependent binding with hyperphosphorylated tau
(PHFtau), the major constituent of NFTs, thereby inducing
aggregation of PHFtau. Herein we report that iron (III) can
also induce aggregation of soluble PHFtau. Importantly, for
the aggregation of PHFtau to occur, iron in the oxidized state
(III) is essential since iron in the reduced state (II) lacks
such ability. Furthermore, iron (III)-induced aggregation is
reversed by reducing iron (III) to iron (II). Thus the
iron-participating aggregation is mediated not only by tau
phosphorylation but also by the transition of iron between
reduced (II) and oxidized (III) states. Further incubation of
insoluble PHFtau aggregates isolated from AD brain with
reducing agents produced liberation of solubilized PHFtau and
iron (II), indicating that PHFtau in association with iron
(III) constitutes the insoluble pool of PHFtau. These results
indicate that iron might play a role in the aggregation of
PHFtau leading to the formation of NFTs in AD brain.
PMID: 12358761 [PubMed - indexed for MEDLINE]
Who loves ya. Tom Jesus was a vegetarian!
http://jesuswasavegetarian.7h.com
Jesus was a vegetarian! http://www.nucleus.com/watchman Moses
was a mystic! http://www.nucleus.com/watchman/light.html