The CNN article on obesity hormone

[Melissa -]

This appears to be evolving from the leptin studies in mice a
few years ago. From CNN:

Scientists find hunger hormone August 8, 2002 Posted: 1:57 PM
EDT (1757 GMT)

LONDON, England -- Scientists say they have discovered a
hormone that prevents the feeling of hunger.

A natural chemical, known as PYY3-36, is normally released
by the gut after eating in proportion to the amount of
calories consumed.

It sends signals to the feeding circuits in the brain that
convey a sense of satiety that reduces the urge to eat.

The find could lead to a new generation of safer and more
effective slimming treatments for some of the one billion
people around the world who are overweight or obese.

A British-led team of international researchers injected the
hormone into the bloodstream of a test group and found that it
tricked the brain into thinking the stomach was full.

Professor Stephen Bloom, from Imperial College London, who led
the research, said: "The discovery that PYY3-36 suppresses
appetite could be of huge benefit to those struggling with
weight problems.

"It's what stops you having the third helping. With over a
billion people across the world now extremely overweight, it
is vital this problem is tackled.

Obesity is based on body mass index (BMI), which is calculated
by dividing weight in kilograms by height in metres squared. A
BMI of more than 30 is considered obese.

People who are overweight are at risk of other health
problems, including diabetes, heart disease, strokes and
certain cancers.

In the tests, 12 volunteers were infused with either
PYY3-36 or salty water in a trial at Hammersmith Hospital,
in west London.

Two hours later, they were offered an unlimited buffet meal.
The hormone group's average calorie intake dropped by a third
over the next 24 hours.

Those who were given PYY3-36 also reported an up to 40 percent
drop in their feelings of hunger for 12 hours after the
treatment.

The research, published in the journal Nature, is part of an
ongoing investigation at Imperial College into human drives
such as appetite.

Team member Dr Rachel Batterham said: "The results show the
hormone PYY3-36 could help in tackling the problem of obesity.

"Rather than using extreme measures such as dieting pills, or
even surgery, PYY3-36 should be able to provide a far safer
and effective alternative."

Professor Rory Shaw, medical director at Hammersmith Hospital,
said: "We have always known that hunger is determined by
complex interactions between the brain, hormones and enzymes
in the gut.

"But this discovery -- that administering a particular hormone
can actually reduce appetite -- is a major step forward on the
road to the development of a new, safe and effective treatment
for obesity."

Bloom said: "It may be possible to identify foods which cause
the release of more PYY3-36, helping to naturally limit
appetite, or it may be possible to create a tablet with a
similar effect, providing an excellent, natural and safe
long-term treatment for obesity."

--
Melissa - Colorado USA
http://dimensional.com/~melissa/forsale.htm

Looking for mid-spectrum libertarians to help me refine and
promote this (preliminary) planetary Bill of Individual
Rights, at http://www.UPAlliance.org/

[Lyle McDon]

Melissa - Colorado USA wrote:
>
> This appears to be evolving from the leptin studies in mice
> a few years ago. From CNN:
>
> Scientists find hunger hormone August 8, 2002 Posted: 1:57
> PM EDT (1757 GMT)
>
> LONDON, England -- Scientists say they have discovered a
> hormone that prevents the feeling of hunger.
>
> A natural chemical, known as PYY3-36, is normally released
> by the gut after eating in proportion to the amount of
> calories consumed.
>
> It sends signals to the feeding circuits in the brain that
> convey a sense of satiety that reduces the urge to eat.
>
> The find could lead to a new generation of safer and more
> effective slimming treatments for some of the one billion
> people around the world who are overweight or obese.
>
> A British-led team of international researchers injected the
> hormone into the bloodstream of a test group and found that
> it tricked the brain into thinking the stomach was full.
>
> Professor Stephen Bloom, from Imperial College London, who
> led the research, said: "The discovery that PYY3-36
> suppresses appetite could be of huge benefit to those
> struggling with weight problems.
>
> "It's what stops you having the third helping. With over a
> billion people across the world now extremely overweight, it
> is vital this problem is tackled.
>
> Obesity is based on body mass index (BMI), which is
> calculated by dividing weight in kilograms by height in
> metres squared. A BMI of more than 30 is considered obese.
>
> People who are overweight are at risk of other health
> problems, including diabetes, heart disease, strokes and
> certain cancers.
>
> In the tests, 12 volunteers were infused with either
> PYY3-36 or salty water in a trial at Hammersmith Hospital,
> in west London.
>
> Two hours later, they were offered an unlimited buffet meal.
> The hormone group's average calorie intake dropped by a
> third over the next 24 hours.
>
> Those who were given PYY3-36 also reported an up to 40
> percent drop in their feelings of hunger for 12 hours after
> the treatment.
>
> The research, published in the journal Nature, is part of an
> ongoing investigation at Imperial College into human drives
> such as appetite.
>
> Team member Dr Rachel Batterham said: "The results show the
> hormone PYY3-36 could help in tackling the problem of
> obesity.
>
> "Rather than using extreme measures such as dieting pills,
> or even surgery, PYY3-36 should be able to provide a far
> safer and effective alternative."
>
> Professor Rory Shaw, medical director at Hammersmith
> Hospital, said: "We have always known that hunger is
> determined by complex interactions between the brain,
> hormones and enzymes in the gut.
>
> "But this discovery -- that administering a particular
> hormone can actually reduce appetite -- is a major step
> forward on the road to the development of a new, safe and
> effective treatment for obesity."
>
> Bloom said: "It may be possible to identify foods which
> cause the release of more PYY3-36, helping to naturally
> limit appetite, or it may be possible to create a tablet
> with a similar effect, providing an excellent, natural and
> safe long-term treatment for obesity."

This has zilch to do with leptin except inasmuch as all of
these hormones acts neurons in the same part of the brain (the
hypothalamus). Leptin comes out of the fat cells (giving the
body overall signals about adiposity and energy stores) while
other hormones (insulin, ghrelin, PYY) give the body signals
about short term energy intake (meal to meal). Ghrelin
stimulates appetite (injections reliably stimulate hunger),
PYY blunts it. Leptin appears to set the tone of the overall
system, and insulin is just another short-term signal.

Lyle

[Melissa In]

Lyle McDonald <lylemcd@onr.com> said, and I quote:

> Melissa - Colorado USA wrote:
>>
>> This appears to be evolving from the leptin studies in mice
>> a few years ago. From CNN:
>>
>> Scientists find hunger hormone August 8, 2002 Posted: 1:57
>> PM EDT (1757 GMT)
>>
>> LONDON, England -- Scientists say they have discovered a
>> hormone that prevents the feeling of hunger.
>>
>> A natural chemical, known as PYY3-36, is normally released
>> by the gut after eating in proportion to the amount of
>> calories consumed.
>>
>> It sends signals to the feeding circuits in the brain that
>> convey a sense of satiety that reduces the urge to eat.
>>
>> The find could lead to a new generation of safer and more
>> effective slimming treatments for some of the one billion
>> people around the world who are overweight or obese.
>>
>> A British-led team of international researchers injected
>> the hormone into the bloodstream of a test group and
>> found that it tricked the brain into thinking the stomach
>> was full.
>>
>> Professor Stephen Bloom, from Imperial College London, who
>> led the research, said: "The discovery that PYY3-36
>> suppresses appetite could be of huge benefit to those
>> struggling with weight problems.
>>
>> "It's what stops you having the third helping. With over a
>> billion people across the world now extremely overweight,
>> it is vital this problem is tackled.
>>
>> Obesity is based on body mass index (BMI), which is
>> calculated by dividing weight in kilograms by height in
>> metres squared. A BMI of more than 30 is considered obese.
>>
>> People who are overweight are at risk of other health
>> problems, including diabetes, heart disease, strokes and
>> certain cancers.
>>
>> In the tests, 12 volunteers were infused with either
>> PYY3-36 or salty water in a trial at Hammersmith Hospital,
>> in west London.
>>
>> Two hours later, they were offered an unlimited buffet
>> meal. The hormone group's average calorie intake dropped by
>> a third over the next 24 hours.
>>
>> Those who were given PYY3-36 also reported an up to 40
>> percent drop in their feelings of hunger for 12 hours after
>> the treatment.
>>
>> The research, published in the journal Nature, is part of
>> an ongoing investigation at Imperial College into human
>> drives such as appetite.
>>
>> Team member Dr Rachel Batterham said: "The results show the
>> hormone PYY3-36 could help in tackling the problem of
>> obesity.
>>
>> "Rather than using extreme measures such as dieting pills,
>> or even surgery, PYY3-36 should be able to provide a far
>> safer and effective alternative."
>>
>> Professor Rory Shaw, medical director at Hammersmith
>> Hospital, said: "We have always known that hunger is
>> determined by complex interactions between the brain,
>> hormones and enzymes in the gut.
>>
>> "But this discovery -- that administering a particular
>> hormone can actually reduce appetite -- is a major step
>> forward on the road to the development of a new, safe and
>> effective treatment for obesity."
>>
>> Bloom said: "It may be possible to identify foods which
>> cause the release of more PYY3-36, helping to naturally
>> limit appetite, or it may be possible to create a tablet
>> with a similar effect, providing an excellent, natural and
>> safe long-term treatment for obesity."
>
> This has zilch to do with leptin except inasmuch as all of
> these hormones acts neurons in the same part of the brain
> (the hypothalamus). Leptin comes out of the fat cells
> (giving the body overall signals about adiposity and energy
> stores) while other hormones (insulin, ghrelin, PYY) give
> the body signals about short term energy intake (meal to
> meal). Ghrelin stimulates appetite (injections reliably
> stimulate hunger), PYY blunts it. Leptin appears to set the
> tone of the overall system, and insulin is just another
> short-term signal.
>
> Lyle

I didn't know, it seemed like something coming from the
initial leptin research, to me, but I'm not a biologist. I'm
glad you know so much about it, though, it's encouraging that
scientists are on the right track for finding people some
help with it.

--
Melissa - Colorado USA
http://dimensional.com/~melissa/forsale.htm

Looking for mid-spectrum libertarians to help me refine and
promote this (preliminary) planetary Bill of Individual
Rights, at http://www.UPAlliance.org/

[Michael Ro]

On 12 Aug 2002 11:56:21 -0600, Melissa in Colorado
<melissa@dim.com> wrote:

|I didn't know, it seemed like something coming from the
initial leptin |research, to me, but I'm not a biologist. I'm
glad you know so much about |it, though, it's encouraging that
scientists are on the right track for |finding people some
help with it.

Lyle McDonald is a known troll plagiarist who makes things up
as he goes along. He is bipolar , or as he calls it
"seasonally nuts"; please do NOT encourage this TROLL.

[Elzinator]

On Mon, 12 Aug 2002 19:31:54 -0400, Michael Roose wrote:
>On 12 Aug 2002 11:56:21 -0600, Melissa in Colorado
><melissa@dim.com> wrote:
>
>|I didn't know, it seemed like something coming from the
>initial leptin |research, to me, but I'm not a biologist. I'm
>glad you know so much about |it, though, it's encouraging
>that scientists are on the right track for |finding people
>some help with it.
>
>Lyle McDonald is a known troll plagiarist who makes things up
>as he goes along. He is bipolar , or as he calls it
>"seasonally nuts"; please do NOT encourage this TROLL.

Oh my, reflecting yourself now, are you?

I believe you hold the degree in plagiarism, sir.

[Michael Ro]

On Mon, 12 Aug 2002 22:07:59 -0400, Elzinator
<elzinator@planetclaire.not> wrote:

|Oh my, reflecting yourself now, are you?
|
|I believe you hold the degree in plagiarism, sir.

And you hold the trophy for passed-around-Usenet-trollop.

How does it feel to be the whore who broke up Williams
marriage?

[Elzinator]

On Mon, 12 Aug 2002 22:12:59 -0400, Michael Roose wrote:
>On Mon, 12 Aug 2002 22:07:59 -0400, Elzinator
><elzinator@planetclaire.not> wrote:
>
>|Oh my, reflecting yourself now, are you?
>|
>|I believe you hold the degree in plagiarism, sir.
>
>And you hold the trophy for passed-around-Usenet-trollop.
>
>How does it feel to be the whore who broke up Williams
>marriage?

You never fail to amuse me with your stories. You've been
haunting/trolling me over a year. Nothing better to do?

Toodles.

Elzi

<insert whatever here

[Michael Ro]

On Mon, 12 Aug 2002 22:35:15 -0400, Elzinator
<elzinator@planetclaire.not> wrote:

|>How does it feel to be the whore who broke up Williams
|>marriage?
|
|You never fail to amuse me with your stories.

I ask again: How does it feel to be the whore who broke up
Williams marriage?