Doe
Sat, Aug-10-02, 13:58
I think this is a .. bad .. thing ..?
1: J Nutr 2002 Aug;132(8):2263-9 Related Articles,
Books, LinkOut
High dietary iron concentrations enhance the formation of
cholesterol oxidation products in the liver of adult rats fed
salmon oil with minimal effects on antioxidant status.
Brandsch C, Ringseis R, Eder K.
Institute of Nutritional Sciences, Martin-Luther-University of
Halle-Wittenberg, D-06108 Halle/Saale, Germany.
The aim of this study was to investigate the effect of high
dietary iron concentrations on the antioxidant status of rats
fed two different types of fat. Four groups of male adult
Sprague-Dawley rats were fed diets with adequate (50 mg iron
supplemented per kg diet) or high (500 mg iron supplemented
per kg diet) iron concentrations with either lard or salmon
oil as dietary fat at 100
g/kg for 12 wk. The antioxidant status of the rats was
profoundly influenced by the type of fat. Rats fed salmon
oil diets had higher concentrations of thiobarbituric
acid-reactive substances (TBARS) (P < 0.001), various
cholesterol oxidation products (COP) (P < 0.001), total and
oxidized glutathione (P < 0.05) and a lower concentration of
alpha-tocopherol (P < 0.05) in liver and plasma than rats
fed lard diets. The iron concentration of the diet did not
influence the concentrations of TBARS, the activities of
superoxide dismutase and glutathione peroxidase or the
concentration of alpha-tocopherol in plasma or liver. The
activity of catalase (P < 0.01) and the concentrations of
total, oxidized and reduced glutathione (P < 0.05) in liver
were slightly but significantly higher in rats fed high iron
diets than in rats fed adequate iron diets, irrespective of
the dietary fat. Rats fed the high iron diets with salmon
oil, moreover, had higher concentrations of various COP in
the liver (P < 0.001) than rats fed adequate iron diets with
salmon oil. These results suggest that feeding a high iron
diet does not generally affect the antioxidant status of
rats but enhances the formation of COP, particularly if the
diet is rich in polyunsaturated fatty acids.
PMID: 12163673 [PubMed - in process]
Who loves ya. Tom http://www.angelfire.com/rebellion/watchman
Jesus was a vegetarian! http://www.nucleus.com/watchman Moses
was a mystic! http://www.nucleus.com/watchman/light.html
1: J Nutr 2002 Aug;132(8):2263-9 Related Articles,
Books, LinkOut
High dietary iron concentrations enhance the formation of
cholesterol oxidation products in the liver of adult rats fed
salmon oil with minimal effects on antioxidant status.
Brandsch C, Ringseis R, Eder K.
Institute of Nutritional Sciences, Martin-Luther-University of
Halle-Wittenberg, D-06108 Halle/Saale, Germany.
The aim of this study was to investigate the effect of high
dietary iron concentrations on the antioxidant status of rats
fed two different types of fat. Four groups of male adult
Sprague-Dawley rats were fed diets with adequate (50 mg iron
supplemented per kg diet) or high (500 mg iron supplemented
per kg diet) iron concentrations with either lard or salmon
oil as dietary fat at 100
g/kg for 12 wk. The antioxidant status of the rats was
profoundly influenced by the type of fat. Rats fed salmon
oil diets had higher concentrations of thiobarbituric
acid-reactive substances (TBARS) (P < 0.001), various
cholesterol oxidation products (COP) (P < 0.001), total and
oxidized glutathione (P < 0.05) and a lower concentration of
alpha-tocopherol (P < 0.05) in liver and plasma than rats
fed lard diets. The iron concentration of the diet did not
influence the concentrations of TBARS, the activities of
superoxide dismutase and glutathione peroxidase or the
concentration of alpha-tocopherol in plasma or liver. The
activity of catalase (P < 0.01) and the concentrations of
total, oxidized and reduced glutathione (P < 0.05) in liver
were slightly but significantly higher in rats fed high iron
diets than in rats fed adequate iron diets, irrespective of
the dietary fat. Rats fed the high iron diets with salmon
oil, moreover, had higher concentrations of various COP in
the liver (P < 0.001) than rats fed adequate iron diets with
salmon oil. These results suggest that feeding a high iron
diet does not generally affect the antioxidant status of
rats but enhances the formation of COP, particularly if the
diet is rich in polyunsaturated fatty acids.
PMID: 12163673 [PubMed - in process]
Who loves ya. Tom http://www.angelfire.com/rebellion/watchman
Jesus was a vegetarian! http://www.nucleus.com/watchman Moses
was a mystic! http://www.nucleus.com/watchman/light.html