Hey, Philip!

[Gisele Hor]

Do you recall the African gene conversion example I sent you
which involved HVR I sites 16355T & 16362C? If so, I just saw
some lineages with these variants connected in a reduced
median network:

Am. J. Hum. Genet., 69:1348-1356, 2001 Do the Four Clades of
the mtDNA Haplogroup L2 Evolve at Different Rates? Antonio
Torroni,1,2 Chiara Rengo,2,4 Valentina Guida,2 Fulvio
Cruciani,2 Daniele Sellitto,5 Alfredo Coppa,3 Fernando Luna
Calderon,6 Barbara Simionati,7 Giorgio Valle,7 Martin
Richards,8 Vincent Macaulay,9 and Rosaria Scozzari2

http://www.journals.uchicago.edu/AJHG/journal/issues/v69n6/01-
3272/013272.html

See Figure 1 - the L2b clade.

Gisele

[Philip Dei]

On Thu, 16 May 2002 05:07:34 GMT, g-horvat@shaw.ca (Gisele
Horvat) wrote:

>Do you recall the African gene conversion example I sent you
>which involved HVR I sites 16355T & 16362C? If so, I just saw
>some lineages with these variants connected in a reduced
>median network:
>
>Am. J. Hum. Genet., 69:1348-1356, 2001 Do the Four Clades of
>the mtDNA Haplogroup L2 Evolve at Different Rates? Antonio
>Torroni,1,2 Chiara Rengo,2,4 Valentina Guida,2 Fulvio
>Cruciani,2 Daniele Sellitto,5 Alfredo Coppa,3 Fernando Luna
>Calderon,6 Barbara Simionati,7 Giorgio Valle,7 Martin
>Richards,8 Vincent Macaulay,9 and Rosaria Scozzari2
>
>http://www.journals.uchicago.edu/AJHG/journal/issues/v69n6/0-
>13272/013272.html
>
>See Figure 1 - the L2b clade.

Got it.

Philip [pdeitik at bcm.tmc.edu]
http://home.att.net/~DNAPaleoAnth

For those folks that have Agent here is my filter file:

Author: Algis Kuliukas Author: Bob Keeter Author: Jabriol
Author: jabriol Author: James Michael Howard Author: Jim
McGinn Author: marc verhaegen Author: Paul Crowley Author: Tim
Tyler Author: Watch Tower AAT Creation CreationEvolve Abortion
Aquatic aquatic

[Philip Dei]

On Thu, 16 May 2002 05:07:34 GMT, g-horvat@shaw.ca (Gisele
Horvat) wrote:

>Do you recall the African gene conversion example I sent you
>which involved HVR I sites 16355T & 16362C? If so, I just saw
>some lineages with these variants connected in a reduced
>median network:
>
>Am. J. Hum. Genet., 69:1348-1356, 2001 Do the Four Clades of
>the mtDNA Haplogroup L2 Evolve at Different Rates? Antonio
>Torroni,1,2 Chiara Rengo,2,4 Valentina Guida,2 Fulvio
>Cruciani,2 Daniele Sellitto,5 Alfredo Coppa,3 Fernando Luna
>Calderon,6 Barbara Simionati,7 Giorgio Valle,7 Martin
>Richards,8 Vincent Macaulay,9 and Rosaria Scozzari2
>
>http://www.journals.uchicago.edu/AJHG/journal/issues/v69n6/0-
>13272/013272.html
>
>See Figure 1 - the L2b clade.

Did you notice that the 3 of 5 shortest branches had mutations
at 16187 or 16189, the other 2 (related) might have had
reversions in the stem we cannot see.

It would be interesting to see what exactly the positional
changes at 187 and 189 were, whadduyathink?

Philip [pdeitik at bcm.tmc.edu]
http://home.att.net/~DNAPaleoAnth

For those folks that have Agent here is my filter file:

Author: Algis Kuliukas Author: Bob Keeter Author: Jabriol
Author: jabriol Author: James Michael Howard Author: Jim
McGinn Author: marc verhaegen Author: Paul Crowley Author: Tim
Tyler Author: Watch Tower AAT Creation CreationEvolve Abortion
Aquatic aquatic

[Gisele Hor]

On Thu, 16 May 2002 10:45:11 -0500, Philip Deitiker
<pdeitik@bcm.tmc.edu> wrote:

>On Thu, 16 May 2002 05:07:34 GMT, g-horvat@shaw.ca (Gisele
>Horvat) wrote:
>
>>Do you recall the African gene conversion example I sent you
>>which involved HVR I sites 16355T & 16362C? If so, I just
>>saw some lineages with these variants connected in a reduced
>>median network:
>>
>>Am. J. Hum. Genet., 69:1348-1356, 2001 Do the Four Clades of
>>the mtDNA Haplogroup L2 Evolve at Different Rates? Antonio
>>Torroni,1,2 Chiara Rengo,2,4 Valentina Guida,2 Fulvio
>>Cruciani,2 Daniele Sellitto,5 Alfredo Coppa,3 Fernando Luna
>>Calderon,6 Barbara Simionati,7 Giorgio Valle,7 Martin
>>Richards,8 Vincent Macaulay,9 and Rosaria Scozzari2
>>
>>http://www.journals.uchicago.edu/AJHG/journal/issues/v69n6/-
>>013272/013272.html
>>
>>See Figure 1 - the L2b clade.
>
>Did you notice that the 3 of 5 shortest branches had
>mutations at 16187 or 16189, the other 2 (related) might have
>had reversions in the stem we cannot see.

You must be referring to Figure 2.

>It would be interesting to see what exactly the positional
>changes at 187 and 189 were, whadduyathink?

They were away from the CRS forms - 187C-->T & 189T-->C (if
I'm understanding you properly).

I'm seeing branch length differences in the Native
American coding region sequences also and find them to be
quite puzzling. This phenomenon is definitely not
restricted to Africa.

Gisele