Creatine, Glutamine and type 2 diabetics

[Tsm126]

I was diagnosed with type 2 diabetes this year. In past years,
I have used creatine and weight lifting to help build strength
and muscle mass. Does anyone know of any side effects of
creatine that would adversely affect someone with type 2
diabetes? Also I've recently heard glutamine is helpful in
building muscle. Any problems with glutamine and type 2
diabetics? Thanks for any help.

[Jimbo]

"Tsm126" <tsm126@aol.com> wrote in message
news:20020630225957.01579.00001671@mb-fw.aol.com...
> I was diagnosed with type 2 diabetes this year. In past
> years, I have used creatine and weight lifting to help build
> strength and muscle mass. Does
anyone
> know of any side effects of creatine that would adversely
> affect someone
with
> type 2 diabetes? Also I've recently heard glutamine is
> helpful in building muscle. Any problems with glutamine and
> type 2 diabetics? Thanks for any help.

Post your message at misc.fitness.weights.

[Jay Tanzma]

Tsm126 wrote:
>
> I was diagnosed with type 2 diabetes this year. In past
> years, I have used creatine and weight lifting to help build
> strength and muscle mass. Does anyone know of any side
> effects of creatine that would adversely affect someone with
> type 2 diabetes? Also I've recently heard glutamine is
> helpful in building muscle. Any problems with glutamine and
> type 2 diabetics? Thanks for any help.

I don't know about glutamine, but creatine adversely affects
insulin and blood glucose in rats. See below.

-Jay

Metabolism 2002 Apr;51(4):518-22

Creatine supplementation alters insulin secretion and glucose
homeostasis in
vivo.

Rooney K, Bryson J, Phuyal J, Denyer G, Caterson I,
Thompson C.

Human Nutrition Unit, Department of Biochemistry, University
of Sydney, Sydney, NSW, Australia.

Dietary creatine supplementation has been used to improve
skeletal muscle performance. However, dietary creatine
manipulation also affects glucose homeostasis. The aim of this
study was to investigate the effect of dietary creatine
supplementation on insulin secretion, glucose tolerance, and
quadriceps glycogen metabolism in chow-fed rats. Forty-eight
rats in total were divided into 2 groups of 24 and were then
subdivided into 6 groups of 8. Rats were fed a diet
supplemented with 0% (CON) or 2% (CREAT) creatine for 2, 4, or
8 weeks. At these 3 time points an oral glucose tolerance test
was performed. Two days later, rats were euthanized and the
pancreas and quadriceps muscles were collected. The peak
insulin response to a glucose challenge was significantly
elevated after both 4 (CON 327 +/- 72 v CREAT 735 +/- 140
pmol/L, P =.01) and 8 (CON 248 +/- 48 v CREAT 588 +/- 136
pmol/L, P =.02) weeks. Fasting insulin levels were also
increased by creatine supplementation for 8 weeks (CON 78 +/-
14 v CREAT 139 +/- 14 pmol/L, P =.01). Glucose tolerance was
not affected until 8 weeks at which point the peak plasma
glucose was elevated in the creatine supplemented group (CON
10.1 +/- 0.6 v CREAT 13.5 +/- 1.5 mmol/L, P =.05). A
significant increase in pancreatic total creatine content was
seen in supplemented animals at 2 (CON 1.2 +/- 0.1 v CREAT 2.7
+/- 0.1 micromol/g wet wt, P =.005), 4 (CON 1.5 +/- 0.2 v
CREAT 2.7 +/- 0.3 micromol/g wet wt, P =.02) and 8 (CON 1.5
+/- 0.1 v CREAT 2.6 +/- 0.1 micromol/g wet wt, P =.005) weeks,
whereas no change in quadriceps total creatine or glycogen
content was observed at any individual time point. This study
shows that prolonged creatine supplementation induces
abnormalities in pancreatic insulin secretion and changes in
glucose homeostasis.

[Jay Tanzma]

Jimbo wrote:
>
> "Tsm126" <tsm126@aol.com> wrote in message
> news:20020630225957.01579.00001671@mb-fw.aol.com...
> > I was diagnosed with type 2 diabetes this year. In past
> > years, I have used creatine and weight lifting to help
> > build strength and muscle mass. Does
> anyone
> > know of any side effects of creatine that would adversely
> > affect someone
> with
> > type 2 diabetes? Also I've recently heard glutamine is
> > helpful in building muscle. Any problems with glutamine
> > and type 2 diabetics? Thanks for any help.
>
> Post your message at misc.fitness.weights.

Yeah, ask a bunch of weight lifters. While you're at it, ask
them about flax oil, too.

-Jay

[Mike]

Jay Tanzman <jtanzman@sph.llu.edu> wrote:
>
>
>Jimbo wrote:
>>
>> "Tsm126" <tsm126@aol.com> wrote in message
>> news:20020630225957.01579.00001671@mb-fw.aol.com...
>> > I was diagnosed with type 2 diabetes this year. In past
>> > years, I have used creatine and weight lifting to help
>> > build strength and muscle mass. Does
>> anyone
>> > know of any side effects of creatine that would adversely
>> > affect someone
>> with
>> > type 2 diabetes? Also I've recently heard glutamine is
>> > helpful in building muscle. Any problems with glutamine
>> > and type 2 diabetics? Thanks for any help.
>>
>> Post your message at misc.fitness.weights.
>
>Yeah, ask a bunch of weight lifters. While you're at it, ask
>them about flax oil, too.
>
>-Jay

Tough crowd<g