Insulin resistance the role of nutrition

[Wuzzy]

ugh, xxx's post makes me feel like not posting, who wants to
post to a place where there is even one ad every year. I hope
jimbo replies..

okay thats probably going to cut my message short

read this month's CJDPR, Vol 63, 1 2002 "insulin resistance:
the role of nutrition" americans are probably not going to be
able to find this article so I'll post a summary of stuff I
found interesting:

-insulin resistance in the periphery (muscle) *precedes* liver
insulin resistance. -The HOMA-IR is not valid in
epidemiological studies of pre-diabetees because it measures
*liver* insulin resistance this is mostly because it's
equation which is the I/Gl ratio is measured in the fasting
state. (this is landmark for those looking at HOMAIR on diet)
- I should devote an entire post just to this point. -Muscle
is the cite of 70-90% of postprandial glucose (mstly to make
glycogen) .'. Insulin resistance at this cite is associated
with postprandial hyperinsulinemia. -liver IR correlates more
strongly with postprandial hyperglycemia than with fasting
hyperglycemia. (liver=30% of glucose disposal, ie. clearance
and storage, muscle=70) -IR is caused either by FFA,
hyperglycemia, paracrine (TNF, inflammation), maybe HPA
Nutritional treatment: two methods: Canadian Diabetes Assoc.:
High carb, low glycemic and low fat emphasis on body weight
loss and low SFA. AMerican Diabetes Assoc: High MUFA diet, the
article also clames ADA to promote glycemic index but I
disagree with them ADA has said repeatedly no GI, just count
carbs(who am i to argue, though) -both CDA/ADA redcommend
203-g of fiber, 10-25 from viscous soluble (Both low SFA, and
both emphasize glucose management rather than IR management)

someone say if I'm missing anything,

and finally when asking someone a question always ask them to
be "brief" this ensures several pages of reply..

[Wuzzy]

(wuzzy) wrote in message

>CJDPR=Canadian journal of dietetic practice.. -The
>HOMA-IR is not valid in epidemiological studies

Another argument(1): High *and* low Insulin/Glucose ratio can
occur in insulin resistant persons! ex. insulin resistant
subject requires twice as much insulin to maintain
normoglycemia. (high I/G) But if there are two subjects with
equal insulin and one has higher blood glucose, the higher
blood glucose subject would be *incorrectly* classified as
"more sensitive."

(1)Diabetes Care 1999 Sep;22(9):1462-70 Insulin sensitivity
indices obtained from oral glucose tolerance testing

[Wuzzy]

mypcos@hotmail.com (wuzzy) wrote in message
news:<d996c21a.0207010656.3c439d42@posting.google.com>...
> (wuzzy) wrote in message
>
> >CJDPR=Canadian journal of dietetic practice.. -The
> >HOMA-IR is not valid in epidemiological studies
>
> Another argument(1): High *and* low Insulin/Glucose ratio
> can occur in insulin resistant persons! ex. insulin
> resistant subject requires twice as much insulin to maintain
> normoglycemia. (high I/G) But if there are two subjects with
> equal insulin and one has higher blood glucose, the higher
> blood glucose subject would be *incorrectly* classified as
> "more sensitive."
>
> (1)Diabetes Care 1999 Sep;22(9):1462-70 Insulin sensitivity
> indices obtained from oral glucose tolerance testing

A cool thing to do is to use and/or constructions, this also
partially gets around "regression to the mean", like if you
select 100 people with high cholesterol and feed them pasta,
their high cholesterol will drop the second time, just
because alot of the people on the high end of cholesterol had
a bad day.. look up "placebo effect and regression to the
mean" on medline..

so yeah a construction of high fasting insulin and high
fasting blood glucose (which are paradoxical except in cases
of diabetes!)

cool huh..