Doe
Tue, Jun-25-02, 23:55
Ann N Y Acad Sci 2002 Jun;967:342-351
Effect of Iron Depletion on Cardiovascular Risk Factors:
Studies in Carbohydrate-Intolerant Patients.
Facchini FS, Saylor KL Department of Medicine, Division of
Nephrology, San Francisco General Hospital and University of
California, San Francisco, California, USA.
[Record supplied by publisher]
Controversy surrounds the role of iron (Fe) in atherosclerosis
(ASCVD), mainly due to the inaccuracy of assessing body Fe
stores with serum ferritin and transferrin saturation.
Quantitative phlebotomy was used to test whether or not
(a) Fe stores are increased in individuals at high risk for
ASCVD and (b) Fe depletion to near-deficiency (NID) levels
is associated with reduction of risk factors for ASCVD.
Thirty-one carbohydrate-intolerant subjects completed the
study. Fe stores were within normal limits (1.5 +/- 0.1
g). At NID, a significant increase of HDL-cholesterol (p <
0.001) and reductions of blood pressure (p < 0.001), total
and LDL-cholesterol (p < 0.001), triglyceride (p < .001),
fibrinogen (p < 0.001) and glucose and insulin responses
to oral glucose loading (p < 0.001) were noted, while
homocysteine plasma concentration remained unchanged.
These effects were largely reversed by a 6-month period of
Fe repletion with reinstitution of Fe sufficiency. Thus,
although individuals at high risk for ASCVD are not
Fe-overloaded, they seem to benefit, metabolically and
hemodynamically, from lowering of body Fe to levels
commonly seen in premenopausal females.
PMID: 12079862
Who loves ya. Tom
Jesus was a vegetarian! http://www.nucleus.com/watchman Moses
was a mystic! http://www.nucleus.com/watchman/light.html
Effect of Iron Depletion on Cardiovascular Risk Factors:
Studies in Carbohydrate-Intolerant Patients.
Facchini FS, Saylor KL Department of Medicine, Division of
Nephrology, San Francisco General Hospital and University of
California, San Francisco, California, USA.
[Record supplied by publisher]
Controversy surrounds the role of iron (Fe) in atherosclerosis
(ASCVD), mainly due to the inaccuracy of assessing body Fe
stores with serum ferritin and transferrin saturation.
Quantitative phlebotomy was used to test whether or not
(a) Fe stores are increased in individuals at high risk for
ASCVD and (b) Fe depletion to near-deficiency (NID) levels
is associated with reduction of risk factors for ASCVD.
Thirty-one carbohydrate-intolerant subjects completed the
study. Fe stores were within normal limits (1.5 +/- 0.1
g). At NID, a significant increase of HDL-cholesterol (p <
0.001) and reductions of blood pressure (p < 0.001), total
and LDL-cholesterol (p < 0.001), triglyceride (p < .001),
fibrinogen (p < 0.001) and glucose and insulin responses
to oral glucose loading (p < 0.001) were noted, while
homocysteine plasma concentration remained unchanged.
These effects were largely reversed by a 6-month period of
Fe repletion with reinstitution of Fe sufficiency. Thus,
although individuals at high risk for ASCVD are not
Fe-overloaded, they seem to benefit, metabolically and
hemodynamically, from lowering of body Fe to levels
commonly seen in premenopausal females.
PMID: 12079862
Who loves ya. Tom
Jesus was a vegetarian! http://www.nucleus.com/watchman Moses
was a mystic! http://www.nucleus.com/watchman/light.html