iron supplementation

[Watchman]

Thought some may be interested in this study.

Med Sci Sports Exerc 2002 May;34(5):876-80

Increased body iron stores in elite road cyclists.

Deugnier Y, Loreal O, Carre F, Duvallet A, Zoulim F, Vinel
JP, Paris JC, Blaison D, Moirand R, Turlin B, Gandon Y,
David V, Megret A, Guinot M

Service des Maladies du Foie and INSERM-U522, Laboratoire
de Physiologie, Laboratoire d'Anatomie Pathologique B,
Departement de Radiologie, Rennes, France.
yves.deugnier@univ-rennes1.fr

[Medline record in process]

BACKGROUND: One third of French elite road cyclists were
found to have hyperferritinemia on antidoping control tests
performed during the Tour de France in 1998. PURPOSE: This
study was undertaken to determine whether hyperferritinemia
corresponded to elevated body iron stores or not and,
affirmatively, what were its mechanism, its clinical
consequences, and its spontaneous course. METHODS: 83 elite
road male cyclists presenting with hyperferritinemia,
defined as serum ferritin level greater than 300
microg.L-1, were studied with respect to consumption of
iron and other drugs, serum iron tests, HFE mutations, and
hepatic iron concentration (HIC; N < 35 micromol.g-1 dry
weight). RESULTS: All cyclists were asymptomatic and had
normal physical and cardiac examination. Their median
(range) serum ferritin, serum iron, and transferrin
saturation levels were 504 microg.L-1 (306-1671), 20
micromol.L-1 (8.5-36.3), and 39% (20-76), respectively. HIC
was increased in 24/27 up to 187 micromol.g-1. Allelic
frequency of the H63D mutation was increased in cyclists
when compared to controls (P = 0.04). However, iron tests
did not differ according to HFE genotypes. Most cyclists
(89%) had been supplemented with iron. The median iron
supplementation was 25.5 g (range: 1.4-336) and correlated
well (P = 0.002) with serum ferritin. Evolution of serum
ferritin levels did not differ whether cyclists had been
continuing iron supplementation or not. CONCLUSION:
Hyperferritinemia in elite road cyclists accounted for
increased body iron stores caused by and persisting after
cessation of excessive iron supplementation. Even when
mild, iron excess may expose to long-term complications and
should be removed, at least at the time when professional
cyclists retire. To prevent iatrogenic iron overload,
supplementation with iron must be done according to serum
ferritin follow-up and not either blindly or on the basis
of serum iron determination only.

PMID: 11984309, UI: 21980152
_______________________________________________________-
__________

Save the above report in [Macintosh] [Text] format Order
documents on this page through Loansome Doc
_______________________________________________________-
__________

Who loves ya. Tom
--
Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses
was a Mystic! http://www.nucleus.com/watchman/light.html

[Mike & Hea]

"watchman" <watchman@nucleus.com> wrote in message
news:3ce44fbf@news.nucleus.com...
> Thought some may be interested in this study.
>
>
> Med Sci Sports Exerc 2002 May;34(5):876-80
>
> Increased body iron stores in elite road cyclists.

Don't you have any general knowledge? Elite cyclists are
notorious for blood doping and erythropoieitin abuse. They are
probably one of the few groups in the world who would benefit
from your anti - iron crusade. Why don't you pester them
instead of us!

--
Mike Collins UK Mikecheatherc@oakwellmount.freeserve.co.uk

[Watchman]

In sci.med.laboratory Mike & Heather Collins
<mikeheatherc@oakwellmount.freeserve.co.uk> wrote:

> "watchman" <watchman@nucleus.com> wrote in message
> news:3ce44fbf@news.nucleus.com...
>> Thought some may be interested in this study.
>>
>>
>> Med Sci Sports Exerc 2002 May;34(5):876-80
>>
>> Increased body iron stores in elite road cyclists.

> Don't you have any general knowledge? Elite cyclists are
> notorious for blood doping and erythropoieitin abuse. They
> are probably one of the few groups in the world who would
> benefit from your anti - iron crusade. Why don't you pester
> them instead of us!

Well since it seems one in ten white Americans has iron excess
and one in three black Americans has it .. and as the article
states .. the MARKER used to assess iron excess seems to be
quite a bit higher than that which
Dr. Jerome Sullivan believes CONSTITUTES iron excess .. then
iron excess is a much greater problem than realized.

But then again .. I thought there WOULD be a few people who
didn't give a FF whether EVERYONE IN THE WORLD had it .. I
don't think I'll take your comments to heart ..

Righto?

Who loves ya. Tom
--
Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses
was a Mystic! http://www.nucleus.com/watchman/light.html

[Dave King]

No, please take the comment to heart you imbecile.

--
~~~~~~~~~~~~~~~~~~~~~
Oral & Maxillofacial Surgeon Diplomate, American Board of Oral
& Maxillofacial Surgery HTTP://WWW.DEOMFS.COM remove 'NOSPAM'
from email to reply "watchman" <watchman@nucleus.com> wrote in
message news:3ce4f81d@news.nucleus.com...
> In sci.med.laboratory Mike & Heather Collins
<mikeheatherc@oakwellmount.freeserve.co.uk> wrote:
>
> > "watchman" <watchman@nucleus.com> wrote in message
> > news:3ce44fbf@news.nucleus.com...
> >> Thought some may be interested in this study.
> >>
> >>
> >> Med Sci Sports Exerc 2002 May;34(5):876-80
> >>
> >> Increased body iron stores in elite road cyclists.
>
> > Don't you have any general knowledge? Elite cyclists are
> > notorious for blood doping and erythropoieitin abuse. They
> > are probably one of the few groups in the world who would
> > benefit
from
> > your anti - iron crusade. Why don't you pester them
> > instead of us!
>
> Well since it seems one in ten white Americans has iron
> excess and one in three black Americans has it .. and as the
> article states .. the MARKER used to assess iron excess
> seems to be quite a bit higher than that which
> Dr. Jerome Sullivan believes CONSTITUTES iron excess .. then
> iron excess is a much greater problem than realized.
>
> But then again .. I thought there WOULD be a few people who
> didn't give a FF whether EVERYONE IN THE WORLD had it .. I
> don't think I'll take your comments to heart ..
>
> Righto?
>
> Who loves ya. Tom
> --
> Jesus was a Vegetarian! http://www.nucleus.com/watchman
> Moses was a Mystic!
> http://www.nucleus.com/watchman/light.html

[Slenon]

Did they let you out of the locked ward again? Take your
medication and quit annoying people until it is time for your
next round of EST.

--
Stev Still dancing in the Phil Zone & scattering Garcia ashes
Stev Lenon MT(ASCP) - In healthcare the ultimate bottom line
is patients not profit Save a cow, eat a PETA member
slenon@tampabay.rr.com http://web.tampabay.rr.com/stevglo/ind-
ex.html/slhomepage92kword.htm

[David Lloy]

watchman wrote:
> Thought some may be interested in this study. Med Sci Sports
> Exerc 2002 May;34(5):876-80 Increased body iron stores in
> elite road cyclists.

Well duhh! (In the US you seem to spell it "doh" which puzzles
me a bit.)

They have been reinjecting themselves with their own frozen
blood for two or three months before the race, so of course
they are high in iron. That's the whole fucking point of
the exercise.

Naive abstract follows.

...to see which way the wind blows.

-dlj.

>
> Deugnier Y, Loreal O, Carre F, Duvallet A, Zoulim F,
> Vinel JP, Paris JC, Blaison D, Moirand R, Turlin B,
> Gandon Y, David V, Megret A, Guinot M
>
> Service des Maladies du Foie and INSERM-U522, Laboratoire
> de Physiologie, Laboratoire d'Anatomie Pathologique B,
> Departement de Radiologie, Rennes, France.
> yves.deugnier@univ-rennes1.fr
>
> [Medline record in process]
>
> BACKGROUND: One third of French elite road cyclists were
> found to have hyperferritinemia on antidoping control
> tests performed during the Tour de France in 1998.
> PURPOSE: This study was undertaken to determine whether
> hyperferritinemia corresponded to elevated body iron
> stores or not and, affirmatively, what were its
> mechanism, its clinical consequences, and its spontaneous
> course. METHODS: 83 elite road male cyclists presenting
> with hyperferritinemia, defined as serum ferritin level
> greater than 300 microg.L-1, were studied with respect to
> consumption of iron and other drugs, serum iron tests,
> HFE mutations, and hepatic iron concentration (HIC; N <
> 35 micromol.g-1 dry weight). RESULTS: All cyclists were
> asymptomatic and had normal physical and cardiac
> examination. Their median (range) serum ferritin, serum
> iron, and transferrin saturation levels were 504
> microg.L-1 (306-1671), 20 micromol.L-1 (8.5-36.3), and
> 39% (20-76), respectively. HIC was increased in 24/27 up
> to 187 micromol.g-1. Allelic frequency of the H63D
> mutation was increased in cyclists when compared to
> controls (P = 0.04). However, iron tests did not differ
> according to HFE genotypes. Most cyclists (89%) had been
> supplemented with iron. The median iron supplementation
> was 25.5 g (range: 1.4-336) and correlated well (P =
> 0.002) with serum ferritin. Evolution of serum ferritin
> levels did not differ whether cyclists had been
> continuing iron supplementation or not. CONCLUSION:
> Hyperferritinemia in elite road cyclists accounted for
> increased body iron stores caused by and persisting after
> cessation of excessive iron supplementation. Even when
> mild, iron excess may expose to long-term complications
> and should be removed, at least at the time when
> professional cyclists retire. To prevent iatrogenic iron
> overload, supplementation with iron must be done
> according to serum ferritin follow-up and not either
> blindly or on the basis of serum iron determination only.
>
> PMID: 11984309, UI: 21980152
> ______________________________________________________-
> ___________
>
> Save the above report in [Macintosh] [Text] format Order
> documents on this page through Loansome Doc
> ______________________________________________________-
> ___________
>
> Who loves ya. Tom

[Greg]

David Lloyd-Jones <dlloyd1104@rogers.com> wrote in message
news:3D72E2E2.8000908@rogers.com...
> watchman wrote:
> > Thought some may be interested in this study. Med Sci
> > Sports Exerc 2002 May;34(5):876-80 Increased body iron
> > stores in elite road cyclists.
>
>
>
>
> Well duhh! (In the US you seem to spell it "doh" which
> puzzles me a bit.)

Dear David:

Many of us in the US use "duh" ( I actually prefer
your "duhh"). The rest went to the government schools
where their union teachers imparted all of the
knowledge they had to share with the little darlings!!

Wayne

Wayne

[Dr. Dickie]

David Lloyd-Jones wrote:

> watchman wrote:
> > Thought some may be interested in this study. Med Sci
> > Sports Exerc 2002 May;34(5):876-80 Increased body iron
> > stores in elite road cyclists.
>
> Well duhh! (In the US you seem to spell it "doh" which
> puzzles me a bit.)
>

Blame it on Homer Simpson (doh!@).

>
> They have been reinjecting themselves with their own frozen
> blood for two or three months before the race, so of course
> they are high in iron. That's the whole fucking point of the
> exercise.
>
> Naive abstract follows.
>
> ...to see which way the wind blows.
>
> -dlj.
>

--

Dr. Dickie Skepticult member in good standing #394-00596-438
Poking kooks with a pointy stick
------------------------------------------------------
"The important thing is not to stop questioning. Curiosity has
its own reason for existing."
E. Einstein

[Jedilworth]

Homer Simpson says "doh." The rest of us say "duhh."

http://fyi.cnn.com/2001/fyi/news/06/15/new.words/

He's even made it to the Oxford English Dictionary!

Judy Dilworth, M.T. (ASCP) Microbiology

David Lloyd-Jones wrote:

> Well duhh! (In the US you seem to spell it "doh" which
> puzzles me a bit.)

[David Lloy]

Dr. Dickie wrote:
> David Lloyd-Jones wrote:
>>watchman wrote:
>>>Thought some may be interested in this study. Med Sci
>>>Sports Exerc 2002 May;34(5):876-80 Increased body iron
>>>stores in elite road cyclists.
>>
>>Well duhh! (In the US you seem to spell it "doh" which
>>puzzles me a bit.)
>>
> Blame it on Homer Simpson (doh!@).
>

Dickie-Doc,

I think you're right, though it surprises me a little: the
Simpsons generally seem to do everything so well. Although I
don't own a TV ("Commercial television is a culture's way of
committing suicide." --
Ds.), the few contacts I've had with the Simpsons lead me to
agree with the church group that recently anointed the show
something like "the most moral thing on television."

Cheers,

-dlj.

[Sir John]

NEWS FLASH!

Dilworth is an authority on duhh, ... Duh!

"JEDilworth" <bactitech@nospamhortonsbay.com> wrote in message
news:3D73875E.A1B4730C@nospamhortonsbay.com...
> Homer Simpson says "doh." The rest of us say "duhh."
>
> http://fyi.cnn.com/2001/fyi/news/06/15/new.words/
>
> He's even made it to the Oxford English Dictionary!
>
> Judy Dilworth, M.T. (ASCP) Microbiology
>
> David Lloyd-Jones wrote:
>
> > Well duhh! (In the US you seem to spell it "doh" which
> > puzzles me a
bit.)

[Spurious G]

In article <3D73E11B.7050300@rogers.com>, David says...
>
>Dr. Dickie wrote:
>> David Lloyd-Jones wrote:
>>>watchman wrote:
>>>>Thought some may be interested in this study. Med Sci
>>>>Sports Exerc 2002 May;34(5):876-80 Increased body iron
>>>>stores in elite road cyclists.
>>>
>>>Well duhh! (In the US you seem to spell it "doh" which
>>>puzzles me a bit.)
>>>
>> Blame it on Homer Simpson (doh!@).
>>
>
>Dickie-Doc,
>
>I think you're right, though it surprises me a little: the
>Simpsons generally seem to do everything so well. Although I
>don't own a TV ("Commercial television is a culture's way of
>committing suicide." --
>me.), the few contacts I've had with the Simpsons lead me to
> agree with the church group that recently anointed the
> show something like "the most moral thing on television."

According to creator Matt Groening, the Homer Simpson
character was based on his own father, also named Homer. The
real-life Homer was a native of Winnipeg, Manitoba.

So... Homer Simpson is actually a Canadian expat.

Sincerely, Spurious George.

[markd]

Nothing new here, it long has been common for adults, but not
menstruating women, to be cautioned not to take an iron
supplement unless advised to do so by a doctor after testing
shows low iron.

>
>http://www.nutritionj.com/content/3/1/2
>
>Who loves ya. Tom Jesus Was A Vegetarian!
>http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
>PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking

[markd]

Tom, is that you? Isn't it more important to have the tests
done to see if iron levels arn't normal before thinking of
ways to lower it? Only 2 percent of the population have iron
overload. What you mention will prevent absorption of iron
from mostly veggie sources, if you are a mostly veggie kind of
guy, that is a problem.

>Any thoughts on the use of Inositol Hexaphosphate (IP6, or
>also called Phytic Acid) to inhibit the absorption of iron
>for males with iron overload?
>
>Also, will this substance chelate the existing iron from
>affected organs, such as the liver and pancreas? Or must
>the old remedy (giving blood) be used monthly to accomplish
>the removal?
>
>I've done a Google search and haven't come up with any
>studies that are really definitive.
>
>GT
>
>
>"doe" <ironjustice@aol.comdoe> wrote in message
>news:20040503093840.09715.00000860@mb-m15.aol.com...
>>
>> http://www.nutritionj.com/content/3/1/2
>>
>> Who loves ya. Tom Jesus Was A Vegetarian!
>> http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore
>> DEAD PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking
>>
>

[markd]

Absolutely, iron should only be supplemented to any degree
on the direction of a doc, as I have often mentioned,
adults shouldn't suppliment at all, unless a womem. Geting
it in or getting it out by supplimentation is not advised
unless testing shows one is not in the normal range. There
is a window for iron level that is normal, only testing
can indicate
it.

>If it is important to have tests done prior to removing iron,
>wouldn't the converse be true?
>
>i.e. having tests done should be mandatory before taking any
> iron supplements - or supplements containing iron such
> as vitamins?
>
>Once it's in there, it's really hard to get out.
>
>GT
>
>
><markd@toad-net.com> wrote in message
>news:4096be43$0$249$4d5ecec7@reader.city-net.com...
>>
>> Tom, is that you? Isn't it more important to have the tests
>> done to
>see
>> if iron levels arn't normal before thinking of ways to
>> lower it?
>Only 2
>> percent of the population have iron overload. What you
>> mention will prevent absorption of iron from mostly veggie
>> sources, if you are a
>mostly
>> veggie kind of guy, that is a problem.
>>
>>
>> >Any thoughts on the use of Inositol Hexaphosphate (IP6,
>> >or also
>called
>> >Phytic Acid) to inhibit the absorption of iron for males
>> >with iron overload?
>> >
>> >Also, will this substance chelate the existing iron from
>> >affected organs, such as the liver and pancreas? Or must
>> >the old remedy (giving blood) be used monthly to
>> >accomplish the removal?
>> >
>> >I've done a Google search and haven't come up with any
>> >studies that are really definitive.
>> >
>> >GT
>> >
>> >
>> >"doe" <ironjustice@aol.comdoe> wrote in message
>> >news:20040503093840.09715.00000860@mb-m15.aol.com...
>> >>
>> >> http://www.nutritionj.com/content/3/1/2
>> >>
>> >> Who loves ya. Tom Jesus Was A Vegetarian!
>> >> http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>> >http://pages.ivillage.com/ironjustice/manisaherbivore
>> >> DEAD PEOPLE WALKING
>> >http://pages.ivillage.com/ironjustice/deadpeoplewalking
>> >>
>> >>
>

[Gt]

If it is important to have tests done prior to removing iron,
wouldn't the converse be true?

i.e. having tests done should be mandatory before taking any
iron supplements - or supplements containing iron such
as vitamins?

Once it's in there, it's really hard to get out.

GT

<markd@toad-net.com> wrote in message
news:4096be43$0$249$4d5ecec7@reader.city-net.com...
>
> Tom, is that you? Isn't it more important to have the
> tests done to
see
> if iron levels arn't normal before thinking of ways to
> lower it?
Only 2
> percent of the population have iron overload. What you
> mention will prevent absorption of iron from mostly veggie
> sources, if you are a
mostly
> veggie kind of guy, that is a problem.
>
>
> >Any thoughts on the use of Inositol Hexaphosphate (IP6,
> >or also
called
> >Phytic Acid) to inhibit the absorption of iron for males
> >with iron overload?
> >
> >Also, will this substance chelate the existing iron from
> >affected organs, such as the liver and pancreas? Or must
> >the old remedy (giving blood) be used monthly to accomplish
> >the removal?
> >
> >I've done a Google search and haven't come up with any
> >studies that are really definitive.
> >
> >GT
> >
> >
> >"doe" <ironjustice@aol.comdoe> wrote in message
> >news:20040503093840.09715.00000860@mb-m15.aol.com...
> >>
> >> http://www.nutritionj.com/content/3/1/2
> >>
> >> Who loves ya. Tom Jesus Was A Vegetarian!
> >> http://jesuswasavegetarian.7h.com Man Is A Herbivore!
> >http://pages.ivillage.com/ironjustice/manisaherbivore
> >> DEAD PEOPLE WALKING
> >http://pages.ivillage.com/ironjustice/deadpeoplewalking
> >>
> >>

[Gt]

Q.E.D.

<markd@toad-net.com> wrote in message
news:4096cb07$0$250$4d5ecec7@reader.city-net.com...
>
> Absolutely, iron should only be supplemented to any degree
> on the direction of a doc, as I have often mentioned, adults
> shouldn't
suppliment
> at all, unless a womem. Geting it in or getting it out by
supplimentation
> is not advised unless testing shows one is not in the normal
> range. There is a window for iron level that is normal, only
> testing can
indicate
> it.
>
> >If it is important to have tests done prior to
> >removing iron,
wouldn't
> >the converse be true?
> >
> >i.e. having tests done should be mandatory before taking
> > any iron supplements - or supplements containing iron
> > such as vitamins?
> >
> >Once it's in there, it's really hard to get out.
> >
> >GT
> >
> >
> ><markd@toad-net.com> wrote in message
> >news:4096be43$0$249$4d5ecec7@reader.city-net.com...
> >>
> >> Tom, is that you? Isn't it more important to have the
> >> tests done
to
> >see
> >> if iron levels arn't normal before thinking of ways to
> >> lower it?
> >Only 2
> >> percent of the population have iron overload. What you
> >> mention
will
> >> prevent absorption of iron from mostly veggie sources, if
> >> you are
a
> >mostly
> >> veggie kind of guy, that is a problem.
> >>
> >>
> >> >Any thoughts on the use of Inositol Hexaphosphate (IP6,
> >> >or also
> >called
> >> >Phytic Acid) to inhibit the absorption of iron for males
> >> >with
iron
> >> >overload?
> >> >
> >> >Also, will this substance chelate the existing iron from
affected
> >> >organs, such as the liver and pancreas? Or must the old
> >> >remedy (giving blood) be used monthly to accomplish the
> >> >removal?
> >> >
> >> >I've done a Google search and haven't come up with any
> >> >studies
that
> >> >are really definitive.
> >> >
> >> >GT
> >> >
> >> >
> >> >"doe" <ironjustice@aol.comdoe> wrote in message
> >> >news:20040503093840.09715.00000860@mb-m15.aol.com...
> >> >>
> >> >> http://www.nutritionj.com/content/3/1/2
> >> >>
> >> >> Who loves ya. Tom Jesus Was A Vegetarian!
> >> >> http://jesuswasavegetarian.7h.com Man Is A Herbivore!
> >> >http://pages.ivillage.com/ironjustice/manisaherbivore
> >> >> DEAD PEOPLE WALKING
> >> >http://pages.ivillage.com/ironjustice/deadpeoplewalking
> >> >>
> >> >>
> >