Craig Heal
Wed, May-15-02, 20:57
Comment in: Am J Clin Nutr. 2002 Apr;75(4):609-10.
Calcium intake influences the association of protein intake
with rates of bone loss in elderly men and women.
Dawson-Hughes B, Harris SS.
Calcium and Bone Metabolism Laboratory, Jean Mayer US
Department of Agriculture Human Nutrition Research Center on
Aging, Tufts University, Boston, MA 02111, USA.
hughesb@hnrc.tufts.edu
BACKGROUND: There is currently no consensus on the effect of
dietary protein intake on the skeleton, but there is some
indication that low calcium intakes adversely influence the
effect of dietary protein on fracture risk. OBJECTIVE: The
objective of the present study was to determine whether
supplemental calcium citrate malate and vitamin D influence
any associations between protein intake and change in bone
mineral density (BMD). DESIGN: Associations between protein
intake and change in BMD were examined in 342 healthy men and
women (aged > or = 65 y) who had completed a 3-y, randomized,
placebo-controlled trial of calcium and vitamin D
supplementation. Protein intake was assessed at the midpoint
of the study with the use of a food-frequency questionnaire
and BMD was assessed every 6 mo by dual-energy X-ray
absorptiometry. RESULTS: The mean (+/-SD) protein intake of
all subjects was 79.1 +/- 25.6 g/d and the mean total calcium
intakes of the supplemented and placebo groups were 1346 +/-
358 and 871 +/- 413 mg/d, respectively. Higher protein intake
was significantly associated with a favorable 3-y change in
total-body BMD in the supplemented group (in a model
containing terms for age, sex, weight, total energy intake,
and dietary calcium intake) but not in the placebo group. The
pattern of change in femoral neck BMD with increasing protein
intake in the supplemented group was similar to that for the
total body. CONCLUSION: Increasing protein intake may have a
favorable effect on change in BMD in elderly subjects
supplemented with calcium citrate malate and vitamin D.
Publication Types: Clinical Trial Randomized Controlled Trial
PMID: 11916767 [PubMed - indexed for MEDLINE]
Calcium intake influences the association of protein intake
with rates of bone loss in elderly men and women.
Dawson-Hughes B, Harris SS.
Calcium and Bone Metabolism Laboratory, Jean Mayer US
Department of Agriculture Human Nutrition Research Center on
Aging, Tufts University, Boston, MA 02111, USA.
hughesb@hnrc.tufts.edu
BACKGROUND: There is currently no consensus on the effect of
dietary protein intake on the skeleton, but there is some
indication that low calcium intakes adversely influence the
effect of dietary protein on fracture risk. OBJECTIVE: The
objective of the present study was to determine whether
supplemental calcium citrate malate and vitamin D influence
any associations between protein intake and change in bone
mineral density (BMD). DESIGN: Associations between protein
intake and change in BMD were examined in 342 healthy men and
women (aged > or = 65 y) who had completed a 3-y, randomized,
placebo-controlled trial of calcium and vitamin D
supplementation. Protein intake was assessed at the midpoint
of the study with the use of a food-frequency questionnaire
and BMD was assessed every 6 mo by dual-energy X-ray
absorptiometry. RESULTS: The mean (+/-SD) protein intake of
all subjects was 79.1 +/- 25.6 g/d and the mean total calcium
intakes of the supplemented and placebo groups were 1346 +/-
358 and 871 +/- 413 mg/d, respectively. Higher protein intake
was significantly associated with a favorable 3-y change in
total-body BMD in the supplemented group (in a model
containing terms for age, sex, weight, total energy intake,
and dietary calcium intake) but not in the placebo group. The
pattern of change in femoral neck BMD with increasing protein
intake in the supplemented group was similar to that for the
total body. CONCLUSION: Increasing protein intake may have a
favorable effect on change in BMD in elderly subjects
supplemented with calcium citrate malate and vitamin D.
Publication Types: Clinical Trial Randomized Controlled Trial
PMID: 11916767 [PubMed - indexed for MEDLINE]