Wuzzy
Sat, Apr-27-02, 23:39
Of course this would only be useful info if it can be
confirmed in the literature apparently it has been observed
many times, as reviewed in More clues to the relationship
between hepatic iron and steatosis: An association with
insulin resistance? Gastroenterology. 1999 Nov;117(5):1241-4.
Review. No abstract available. PMID: 10535890 [PubMed -
indexed for MEDLINE]
The association between obesity, dyslipidemia, diabetes
mellitus, and hepatic steatosis has been recognized for some
time.1,2 Recently, interest has focused on the association of
iron overload, albeit milder than in hemochromatosis, and
hepatic steatosis.3,4 Most studies to date have identified
patients with steatosis and then looked at the associated
clinicopathologic features. Mendler et al.5 in this issue of
GASTROENTEROLOGY now show an association between hepatic iron
overload and steatosis by approaching this clinical issue
from another perspective: identifying patients with primary
iron overload who are not homozygous for the Cys282Tyr
mutation of HFE and studying the clinicopathologic correlates
of this iron overload. In their study group of 161 patients,
52% had steatosis and virtually all (94% of those with
available data) had evidence of insulin resistance based on
the presence of one or more components of the insulin
resistance syndrome (IRS).
confirmed in the literature apparently it has been observed
many times, as reviewed in More clues to the relationship
between hepatic iron and steatosis: An association with
insulin resistance? Gastroenterology. 1999 Nov;117(5):1241-4.
Review. No abstract available. PMID: 10535890 [PubMed -
indexed for MEDLINE]
The association between obesity, dyslipidemia, diabetes
mellitus, and hepatic steatosis has been recognized for some
time.1,2 Recently, interest has focused on the association of
iron overload, albeit milder than in hemochromatosis, and
hepatic steatosis.3,4 Most studies to date have identified
patients with steatosis and then looked at the associated
clinicopathologic features. Mendler et al.5 in this issue of
GASTROENTEROLOGY now show an association between hepatic iron
overload and steatosis by approaching this clinical issue
from another perspective: identifying patients with primary
iron overload who are not homozygous for the Cys282Tyr
mutation of HFE and studying the clinicopathologic correlates
of this iron overload. In their study group of 161 patients,
52% had steatosis and virtually all (94% of those with
available data) had evidence of insulin resistance based on
the presence of one or more components of the insulin
resistance syndrome (IRS).