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John 'The
Sat, Apr-27-02, 23:39
University of Pittsburgh Research Uncovers New Mechanism That
May Be the Cause of Mild Cognitive Impairment
http://biz.yahoo.com/prnews/020131/phth014_1.html "The results
are surprising even to the researchers conducting the study
and may explain why current medications don't improve memory
function effectively. ... The results are almost the opposite
of what most researchers believed
- that a decrease in ChAT levels causes MCI - the theory
behind today's most popular Alzheimer's treatments, which
include drugs meant to boost levels of the enzyme's product,
the neurotransmitter acetylcholine (ACh). ... In this study,
... they found ChAT levels were actually increased in people
with MCI, but returned to normal levels in people with
early-stage AD. Only people with end-stage AD had ChAT
levels below normal."

Upregulation of choline acetyltransferase activity in
hippocampus and frontal cortex of elderly subjects with mild
cognitive impairment http://www3.interscience.wiley.com/cgi-b-
in/abstract/90011237/START Steven T. DeKosky

Annals of Neurology Volume 51, Issue 2, 2002. Pages: 145-155
Challenging assumptions about Alzheimer's disease: Mild
cognitive impairment and the cholinergic hypothesis John C.
Morris Annals of Neurology Volume 51, Issue 2, 2002. Pages:
143-144 No abstract.
--
John Gohde, Achieving good health is an Art, NOT a Science!

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