amandawald
Sat, Jul-12-08, 13:00
This came through to me today via a Google Alert I had posted (on "enzymes" of all things!!!)
Health & Fitness : Are The Most Commonly Prescribed Drugs Of Our Time Safe? on 2008/7/12 3:20:00
(Prudent Press Agency)
New research is revealing some alarming concerns over the safety of Statin agents and questioning their effectiveness in a high percentage of patients taking these drugs.
How do Statins Work? The process of producing cholesterol begins with a two carbon molecule, acetyl-CoA, known as the "building block of life." Acetyl-CoA molecules combine to form hydroxymethyl glutaric acid (HMG). The enyme HMG-CoA reductase is required for mevalonate to be produced from HMG-CoA reductase. Statin drugs inhibit this enzyme and that is why they are known as HMG-CoA reductase inhibitors. This is the reason for the reported numerous side effects.
Statin drugs don't just inhibit the production of cholesterol. Statins inhibit the production of an entire group of intermediary enzymes and molecules that have essential biochemical functions. The mevalonate chain produces 3 end products and one of those is Cholesterol. Ubiquinone and dolichol are the others.
Ubiquinone also known as Co-Enzyme Q10 is an essential cellular nutrient formed in the mitochondria and is necessary for ATP production, functioning as an electron transporter to cytochrome oxidase, the primary respiratory enzyme. High levels of Co-Q10 are required by the heart to function. Ubiquinone, a form of Co-Q10 is in all cell membranes where it plays a vital role in maintaining proper cell membrane structure for nerves and muscles to function. Reduction in serum Ubiquinone levels have been described after statin therapy.( Mabuchi H, et al, J Atherosclero Thromb. 2005; 12(2) : 111-9)
Studies have shown that the use of statin agents for cholesterol control will reduce the level of co-enzyme q-10 by up to 40%. It appears that these statin agents, by altering membrane function actually also impair energy transport to these muscles necessary to keep them functioning properly. Co-Q10 deficiency can cause muscle wasting, pain and weakness and heart failure (the heart is a muscle!).
Proteins are synthesized within the membranes of the endoplasmic reticulum. This complex creation of peptides is directed by dolichol phosphate. The Dolichols are also critical in the assembly of glycoproteins, which allow complex protein structures to fold and interact with receptors and membranes. Dolichol-mediated processes create complex neuropeptides, and mechanisms critical in cellular communication, identification, and immune function. The reality of Dolichol inhibition by statin agents is evident and the resultant turmoil in cellular function is not unexpected. It is also not unexpected that altered cognition and abnormal behavior can result from statin induced neuropeptide formation.
Another common side effect associated with statin agents when used to dramatically reduce cholesterol levels are the neurodegenerative type diseases, almost like Lou Gehrig's disease or Multiple sclerosis, and this is because there is damage to the cellular membranes that make up the insulation around the nerves. It is like electrical wiring in an old house where the insulation around the wire has broken down leaving exposed wiring. These poorly functioning nerves and membranes result in muscle aches/pains as well as decreased strength and decreased nerve function. Memory and thought process may also be severely affected.
Drastic Cholesterol Reduction. It seems that a lot of these problems begin when cholesterol levels become elevated and aggressive reduction occurs with the use of statin agents. Therefore elevated cholesterol levels have been described as the initiating phase in the development of atherosclerosis. Of course, statins inhibit the production of cholesterol--they do this very well. Cholesterol is the body's repair substance: scar tissue contains high levels of cholesterol, including scar tissue in the arteries. Cholesterol is the precursor to vitamin D, necessary for numerous biochemical processes including mineral metabolism. The use of statin agents will reduce the synthesis of Vitamin D. Studies have identified the increased incidence of musculoskeletal pain in patients who are vitamin D deficient, and that replacement results in dramatic improvement.(Al Faraj S.,et al. Vitamin D Deficiency and chronic low back pain in Saudi Arabia," Spine 2003; 28(2): 177-9).
A number of patients describe gastrointestinal symptoms and diarrhea associated with statin therapy. Unfortunately after an extensive gastrointestinal workup, the statin therapy is not discontinued. Statin agents reduce bile salts production, which is required for the digestion of fat. Those who suffer from low cholesterol often have trouble digesting fats. Cholesterol also functions as a powerful antioxidant, thus protecting us against cancer and aging.
It is no surprise that the aggressive control of cholesterol, typical of statin therapy, in an attempt to reduce cardiovascular disease, in itself produces its own disease process. Even though statins have not been proven to decrease the risk of heart attacks and strokes for those not suffering from heart disease.
Copyright (c) 2008 New Health Corp.
About The Author
Gary Stanton, Natural Health advocate and Holistic Nutritionist and Robert Carlson, MD FACS, board certified in General and Thoracic Surgery, participated in cardiovascular research at Harvard University and is a fellow of the American College of Surgeons. He received "America's Top Doctor Award" in Cardiothoracic surgery in 2003 and in 2007. Dr. Carlson is also a Medical Advisor to New Health Corp. http://www.heartsavior.com Tel: 1-877-263-3555
Health & Fitness : Are The Most Commonly Prescribed Drugs Of Our Time Safe? on 2008/7/12 3:20:00
(Prudent Press Agency)
New research is revealing some alarming concerns over the safety of Statin agents and questioning their effectiveness in a high percentage of patients taking these drugs.
How do Statins Work? The process of producing cholesterol begins with a two carbon molecule, acetyl-CoA, known as the "building block of life." Acetyl-CoA molecules combine to form hydroxymethyl glutaric acid (HMG). The enyme HMG-CoA reductase is required for mevalonate to be produced from HMG-CoA reductase. Statin drugs inhibit this enzyme and that is why they are known as HMG-CoA reductase inhibitors. This is the reason for the reported numerous side effects.
Statin drugs don't just inhibit the production of cholesterol. Statins inhibit the production of an entire group of intermediary enzymes and molecules that have essential biochemical functions. The mevalonate chain produces 3 end products and one of those is Cholesterol. Ubiquinone and dolichol are the others.
Ubiquinone also known as Co-Enzyme Q10 is an essential cellular nutrient formed in the mitochondria and is necessary for ATP production, functioning as an electron transporter to cytochrome oxidase, the primary respiratory enzyme. High levels of Co-Q10 are required by the heart to function. Ubiquinone, a form of Co-Q10 is in all cell membranes where it plays a vital role in maintaining proper cell membrane structure for nerves and muscles to function. Reduction in serum Ubiquinone levels have been described after statin therapy.( Mabuchi H, et al, J Atherosclero Thromb. 2005; 12(2) : 111-9)
Studies have shown that the use of statin agents for cholesterol control will reduce the level of co-enzyme q-10 by up to 40%. It appears that these statin agents, by altering membrane function actually also impair energy transport to these muscles necessary to keep them functioning properly. Co-Q10 deficiency can cause muscle wasting, pain and weakness and heart failure (the heart is a muscle!).
Proteins are synthesized within the membranes of the endoplasmic reticulum. This complex creation of peptides is directed by dolichol phosphate. The Dolichols are also critical in the assembly of glycoproteins, which allow complex protein structures to fold and interact with receptors and membranes. Dolichol-mediated processes create complex neuropeptides, and mechanisms critical in cellular communication, identification, and immune function. The reality of Dolichol inhibition by statin agents is evident and the resultant turmoil in cellular function is not unexpected. It is also not unexpected that altered cognition and abnormal behavior can result from statin induced neuropeptide formation.
Another common side effect associated with statin agents when used to dramatically reduce cholesterol levels are the neurodegenerative type diseases, almost like Lou Gehrig's disease or Multiple sclerosis, and this is because there is damage to the cellular membranes that make up the insulation around the nerves. It is like electrical wiring in an old house where the insulation around the wire has broken down leaving exposed wiring. These poorly functioning nerves and membranes result in muscle aches/pains as well as decreased strength and decreased nerve function. Memory and thought process may also be severely affected.
Drastic Cholesterol Reduction. It seems that a lot of these problems begin when cholesterol levels become elevated and aggressive reduction occurs with the use of statin agents. Therefore elevated cholesterol levels have been described as the initiating phase in the development of atherosclerosis. Of course, statins inhibit the production of cholesterol--they do this very well. Cholesterol is the body's repair substance: scar tissue contains high levels of cholesterol, including scar tissue in the arteries. Cholesterol is the precursor to vitamin D, necessary for numerous biochemical processes including mineral metabolism. The use of statin agents will reduce the synthesis of Vitamin D. Studies have identified the increased incidence of musculoskeletal pain in patients who are vitamin D deficient, and that replacement results in dramatic improvement.(Al Faraj S.,et al. Vitamin D Deficiency and chronic low back pain in Saudi Arabia," Spine 2003; 28(2): 177-9).
A number of patients describe gastrointestinal symptoms and diarrhea associated with statin therapy. Unfortunately after an extensive gastrointestinal workup, the statin therapy is not discontinued. Statin agents reduce bile salts production, which is required for the digestion of fat. Those who suffer from low cholesterol often have trouble digesting fats. Cholesterol also functions as a powerful antioxidant, thus protecting us against cancer and aging.
It is no surprise that the aggressive control of cholesterol, typical of statin therapy, in an attempt to reduce cardiovascular disease, in itself produces its own disease process. Even though statins have not been proven to decrease the risk of heart attacks and strokes for those not suffering from heart disease.
Copyright (c) 2008 New Health Corp.
About The Author
Gary Stanton, Natural Health advocate and Holistic Nutritionist and Robert Carlson, MD FACS, board certified in General and Thoracic Surgery, participated in cardiovascular research at Harvard University and is a fellow of the American College of Surgeons. He received "America's Top Doctor Award" in Cardiothoracic surgery in 2003 and in 2007. Dr. Carlson is also a Medical Advisor to New Health Corp. http://www.heartsavior.com Tel: 1-877-263-3555