Ironjustic
Sun, May-25-08, 06:16
Physiopathology of haemophilic arthropathy Authors: LAFEBER,
F. P. J. G.1; MIOSSEC, P.2; VALENTINO, L. A.3
Source: Haemophilia, Volume 14, Supplement 4, July 2008 ,
pp. 3-9(7)
Publisher: Blackwell Publishing Abstract:
Summary.
Haemophilic arthropathy, which shares some clinical and
biological injury characteristics with rheumatoid arthritis,
is characterized by two main features: chronic proliferative
synovitis and cartilage destruction. It is the consequence of
repeated extravasation of blood into joint cavities, but its
exact pathogenesis, particularly with regard to early changes
in the joint, is still incompletely understood. This review
presents recent findings obtained in experiments performed in
vitro and using animal models, which have improved our
knowledge of the pathogenesis of haemophilic arthropathy.
These experimental studies show that haemophilic arthropathy
is a multifactorial event in which the deposit of iron in the
joints appears to exert a central role. First, iron may
promote the apoptosis of chondrocytes by catalysing the
formation of oxygen metabolites; this may explain the fact
that intra-articular blood exerts a directly harmful effect on
cartilage before, and independent of synovial changes.
Secondly, iron may also act on the synovial membrane by
favouring its proliferation through the induction of
proto-oncogenes involved in cellular proliferation and
stimulation of inflammatory cytokines as well as abrogation of
apoptosis. These two processes, one degenerative and
cartilage-mediated, the other inflammatory and
synovium-mediated could occur in parallel or sequentially.
Overall, it may be expected that these experimental results
will yield new therapeutic strategies capable of effectively
preventing the occurrence of this still serious and common
complication in patients with severe haemophilia. Keywords:
arthropathy; blood; cartilage; haemophilia; joint; synovitis
Document Type: Research article
DOI: 10.1111/j.1365-2516.2008.01732.x
Affiliations: 1: Department of Rheumatology and Clinical
Immunology, University Medical Center Utrecht, Utrecht, The
Netherlands 2: Department of Immunology and Rheumatology,
H=F4pital Edouard Herriot, Lyon, France 3: Hemophilia and
Thrombophilia Center, Rush University Medical Center,
Chicago, IL, USA
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
F. P. J. G.1; MIOSSEC, P.2; VALENTINO, L. A.3
Source: Haemophilia, Volume 14, Supplement 4, July 2008 ,
pp. 3-9(7)
Publisher: Blackwell Publishing Abstract:
Summary.
Haemophilic arthropathy, which shares some clinical and
biological injury characteristics with rheumatoid arthritis,
is characterized by two main features: chronic proliferative
synovitis and cartilage destruction. It is the consequence of
repeated extravasation of blood into joint cavities, but its
exact pathogenesis, particularly with regard to early changes
in the joint, is still incompletely understood. This review
presents recent findings obtained in experiments performed in
vitro and using animal models, which have improved our
knowledge of the pathogenesis of haemophilic arthropathy.
These experimental studies show that haemophilic arthropathy
is a multifactorial event in which the deposit of iron in the
joints appears to exert a central role. First, iron may
promote the apoptosis of chondrocytes by catalysing the
formation of oxygen metabolites; this may explain the fact
that intra-articular blood exerts a directly harmful effect on
cartilage before, and independent of synovial changes.
Secondly, iron may also act on the synovial membrane by
favouring its proliferation through the induction of
proto-oncogenes involved in cellular proliferation and
stimulation of inflammatory cytokines as well as abrogation of
apoptosis. These two processes, one degenerative and
cartilage-mediated, the other inflammatory and
synovium-mediated could occur in parallel or sequentially.
Overall, it may be expected that these experimental results
will yield new therapeutic strategies capable of effectively
preventing the occurrence of this still serious and common
complication in patients with severe haemophilia. Keywords:
arthropathy; blood; cartilage; haemophilia; joint; synovitis
Document Type: Research article
DOI: 10.1111/j.1365-2516.2008.01732.x
Affiliations: 1: Department of Rheumatology and Clinical
Immunology, University Medical Center Utrecht, Utrecht, The
Netherlands 2: Department of Immunology and Rheumatology,
H=F4pital Edouard Herriot, Lyon, France 3: Hemophilia and
Thrombophilia Center, Rush University Medical Center,
Chicago, IL, USA
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk