Ironjustic
Fri, May-23-08, 17:16
The metal ion theory of ageing: dietary target hazard
quotients beyond radicals. Naughton DP, Petroczi A Immun
Ageing 2008 May 20; 5(1):3.
ABSTRACT: Numerous theories of ageing exist and many are
interconnected when viewed through a modern integrative
biology perspective. Diet provides a link to a large number of
the theories that prevail at the molecular levels. In
particular, metal ions form key elements of the radical theory
along with having established roles in several age-related
neurodegenerative disorders. Lifetime exposure to metals has
been linked to ageing by contributions to oxidative stress and
neurodegenerative disorders. As many foodstuffs contain high
levels and diverse profiles of metals, their cumulative effect
on ageing warrants investigation. The cumulative level of
concern from environmental exposure can be expressed as a
dimensionless index of target hazard quotient (THQ) or for
known carcinogens, the target cancer risk (TR). This paper
posits that a quantifiable relationship exists between ageing
and level of concern resulting from cumulated metal exposure;
and that this relationship can be used to develop an
ageing-related index of concern from chronic metal ion
exposure. As individual differences may facilitate or moderate
this cumulated exposure, the potential influence on ageing or
on the development of neurodegenerative disorders should be
included into the model.
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Immunity & ageing : I & A [Immun Ageing]
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
quotients beyond radicals. Naughton DP, Petroczi A Immun
Ageing 2008 May 20; 5(1):3.
ABSTRACT: Numerous theories of ageing exist and many are
interconnected when viewed through a modern integrative
biology perspective. Diet provides a link to a large number of
the theories that prevail at the molecular levels. In
particular, metal ions form key elements of the radical theory
along with having established roles in several age-related
neurodegenerative disorders. Lifetime exposure to metals has
been linked to ageing by contributions to oxidative stress and
neurodegenerative disorders. As many foodstuffs contain high
levels and diverse profiles of metals, their cumulative effect
on ageing warrants investigation. The cumulative level of
concern from environmental exposure can be expressed as a
dimensionless index of target hazard quotient (THQ) or for
known carcinogens, the target cancer risk (TR). This paper
posits that a quantifiable relationship exists between ageing
and level of concern resulting from cumulated metal exposure;
and that this relationship can be used to develop an
ageing-related index of concern from chronic metal ion
exposure. As individual differences may facilitate or moderate
this cumulated exposure, the potential influence on ageing or
on the development of neurodegenerative disorders should be
included into the model.
--------------------------------------------------------------
-------------------
Immunity & ageing : I & A [Immun Ageing]
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk