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Ironjustic
Thu, May-22-08, 17:16
Iron withholding: a defense against disease. J Alzheimers Dis
2008 May; 13(4):451-63. Weinberg ED, Miklossy J

Excessive and misplaced iron promotes an array of
neurodegenerative and endocrine diseases as well as
cardiomyopathy, arthropathy, neoplasia and infection.
Vertebrates maintain an iron withholding defense system
designed to prevent accumulation of redox-active (free) iron
in sensitive sites and to sequester the metal in innocuous
packages. Numerous genetic, behavioral and environmental
factors counteract the defense system. Our increasing
awareness of the pathologic roles of iron, as well as of the
methods for prevention of iron loading coupled with
intensified research and development of tissue specific iron
chelator drugs, can be expected to yield marked improvements
in human health. Journal of Alzheimer's disease : JAD [J
Alzheimers Dis] ----------------------------------------------
------------------------------= =AD-----

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