Intestinal Mucus?

[Kumar]

Hello,

Greetings!!

Can there be some instabilty or abnormality in intestinal
mucus generation which can interfere in normal absorption of
glucose and other nutrients (non-Cystic Fibrosis related)
impacting on blood levels?

Best wishes.

[Kumar]

On Mar 14, 7:57=A0pm, Dawid Michalczyk
<d...@eonworks.com> wrote:
> Kumar wrote:
> > Hello,
>
> > Greetings!!
>
> > Can there be some instabilty or abnormality in intestinal
> > mucus generation which can interfere in normal absorption
> > of glucose and other nutrients (non-Cystic Fibrosis
> > related) impacting on blood levels?
>
> Vitamin A deficiency increases mucus production in general.
> If excess mucus production can interfere in normal
> absorption of glucose and other nutrients I do not know. But
> since so much is interconnected in human body, it may be
> worth looking into that.
>
> --
> Dawid Michalczykhttp://www.selfgrowth.com/experts/dawid_mic-
> halczyk.html

Thanks.

Three aspects can be thought;

1. Decreased absorption of glucose and other nutrients esp.
big molecules due to thick mucus layer in intestines.

2. Enhanced absorption due to trapping of nutrient's molecules
in intestinal mucus for prolonged time.

3. Decreased satiety of one or few nutrients due to decreased
absorption caused by thick intestinal mucus resulting
continual and excess cravings leading to overeating and
increased levels in blood.

Its role in respiratory and reproductive system loos to be
well sutudied but in digestive tract--pancreas, intestines
etc. look to be not yet clear. Ingestion of phelgum and post
nasal drips in few patients can also have some relevance.
Mucolytic and mucus forming agents an cystic fibrosis, mucus
in stool can be checked for this purpose.

[Kumar]

On Mar 16, 5:41=A0pm, Kumar <lordshiva5...@gmail.com> wrote:
> On Mar 15, 12:00=A0pm, Kumar <lordshiva5...@gmail.com>
> wrote:
>
>
>
>
>
> > On Mar 14, 7:57=A0pm, Dawid Michalczyk <d...@eonworks.com>
> > wrote:
>
> > > Kumar wrote:
> > > > Hello,
>
> > > > Greetings!!
>
> > > > Can there be some instabilty or abnormality in
> > > > intestinal mucus generation which can interfere in
> > > > normal absorption of glucose and other nutrients
> > > > (non-Cystic Fibrosis related) impacting on blood
> > > > levels?
>
> > > Vitamin A deficiency increases mucus production in
> > > general. If excess mucus production can interfere in
> > > normal absorption of glucose and oth=
er
> > > nutrients I do not know. But since so much is
> > > interconnected in human body, it may be worth looking
> > > into that.
>
> > > --
> > > Dawid Michalczykhttp://www.selfgrowth.com/experts/dawid-
> > > _michalczyk.htm=
l
>
> > Thanks.
>
> > Three aspects can be thought;
>
> > 1. Decreased absorption of glucose and other nutrients
> > esp. big molecules due to thick mucus layer in
> > intestines.
>
> > 2. Enhanced absorption due to trapping of nutrient's
> > molecules in intestinal mucus for prolonged time.
>
> > 3. Decreased satiety of one or few nutrients due to
> > decreased absorption caused by thick intestinal mucus
> > resulting continual and excess cravings leading to
> > overeating and increased levels in blood.
>
> > Its role in respiratory and reproductive system loos to be
> > well sutudied but in digestive tract--pancreas, intestines
> > etc. look to be not yet clear. Ingestion of phelgum and
> > post nasal drips in few patients can also have some
> > relevance. Mucolytic and mucus forming agents an cystic
> > fibrosis, mucus in stool can be checked for this purpose.-
> > Hide quoted text -
>
> > - Show quoted text -
>
> I am not sure, whether pepsin and other protease enzyme by
> their proeolysis and mcolytic action can break down mucus
> and nutralize effectiveness of thick or excess mucus in
> digestive tract. If so, some abnormality in digestive
> enzymes can also be responible for intestinal mucus. Do
> anyone know about it?
>
> I read in one drug index, one cough mixture claiming to
> increase effectiveness of antibiotics by mucosupperessive,
> mucolytic and mucokinetic action of cough syrup. Ths can
> address my thoughts about possible link of intestinal mucus
> with absorption. ??- Hide quoted text -
>
> - Show quoted text -

One manufacturer of a cough syrup, composed of ambroxol,
terbutaline, guaiphenesin & menthol, claimed that their syrup
Xpect-B 1. enhances antibiotic penetration and is mucolytic &
mucokinetic 2. Improve airway clearance & added antiallergic
action, 3. US FDA approved expectorant 4. Local soothing &
counter irritant action respectively to its composition
mentioned above.

If intestinal mucus quality and quantity can be related to
motality, digestion and absorption of foods, the claim can be
relevant. Such proteolytic, mucolytic, Mucokinetic &
muco-expectorant can also be linked to digestive
enzymes(pepsin, trypsin etc.) whose secretions can be effected
by digestive evironment/pH. Digestive microorganisms/GUT flora
or Probiotics can also be related to breakdown of protiens,
mucus etc. I am bit surprised, whether this issue is suitably
attended or not inspite of having prime importance as "acid,
base & water (mucus) balance" can also be related to ,
environmental, constitutional and immune mediators.

[Kumar]

On Mar 15, 12:00=A0pm, Kumar <lordshiva5...@gmail.com> wrote:
> On Mar 14, 7:57=A0pm, Dawid Michalczyk
> <d...@eonworks.com> wrote:
>
>
>
>
>
> > Kumar wrote:
> > > Hello,
>
> > > Greetings!!
>
> > > Can there be some instabilty or abnormality in
> > > intestinal mucus generation which can interfere in
> > > normal absorption of glucose and other nutrients
> > > (non-Cystic Fibrosis related) impacting on blood levels?
>
> > Vitamin A deficiency increases mucus production in
> > general. If excess mucus production can interfere in
> > normal absorption of glucose and other=

> > nutrients I do not know. But since so much is
> > interconnected in human body, it may be worth looking
> > into that.
>
> > --
> > Dawid Michalczykhttp://www.selfgrowth.com/experts/dawid_m-
> > ichalczyk.html
>
> Thanks.
>
> Three aspects can be thought;
>
> 1. Decreased absorption of glucose and other nutrients esp.
> big molecules due to thick mucus layer in intestines.
>
> 2. Enhanced absorption due to trapping of nutrient's
> molecules in intestinal mucus for prolonged time.
>
> 3. Decreased satiety of one or few nutrients due to
> decreased absorption caused by thick intestinal mucus
> resulting continual and excess cravings leading to
> overeating and increased levels in blood.
>
> Its role in respiratory and reproductive system loos to be
> well sutudied but in digestive tract--pancreas, intestines
> etc. look to be not yet clear. Ingestion of phelgum and
> post nasal drips in few patients can also have some
> relevance. Mucolytic and mucus forming agents an cystic
> fibrosis, mucus in stool can be checked for this purpose.-
> Hide quoted text -
>
> - Show quoted text -

I am not sure, whether pepsin and other protease enzyme by
their proeolysis and mcolytic action can break down mucus and
nutralize effectiveness of thick or excess mucus in digestive
tract. If so, some abnormality in digestive enzymes can also
be responible for intestinal mucus. Do anyone know about it?

I read in one drug index, one cough mixture claiming to
increase effectiveness of antibiotics by mucosupperessive,
mucolytic and mucokinetic action of cough syrup. Ths can
address my thoughts about possible link of intestinal mucus
with absorption. ??

[Kofi]

> Can there be some instabilty or abnormality in intestinal
> mucus generation which can interfere in normal absorption of
> glucose and other nutrients (non-Cystic Fibrosis related)
> impacting on blood levels?

Yes. When you lose gut barrier function, you can get
undigested food coming into contact with the immune system.
The resulting inflammation/autoimmunity can further damage
angiogenesis and cause nutritional deficiency.

This happens through several routes. In many autoimmune gut
conditions, butyrate uptake is defective. Without butyrate
(and enough carnitine to properly metabolize it), you lose the
histone acetylation you need to make more mucous (via mucin
genes). Turns out vitamin D3 also needs histone acetylation to
make the innate antimicrobial peptide cathelicidin which is
vital for gut barrier function - and it just so happens
cathelicidin has antiinflammatory/antiallergy properties.
(HIF-1a is a crucial intermediary gene in this chain.)

Since symbiotic bacteria living in the gut produce butyrate
from undigested fiber, you can set this whole ugly process
in motion by taking antibiotics long enough - especially if
you combine it with a crappy American diet rich in sugar and
low in fiber.

[Kumar]

On Mar 21, 7:43=A0am, Kofi <k...@anon.un> wrote:
> > Can there be some instabilty or abnormality in intestinal
> > mucus generation which can interfere in normal absorption
> > of glucose and other nutrients (non-Cystic Fibrosis
> > related) impacting on blood levels?
>
> Yes. =A0When you lose gut barrier function, you can get
> undigested food coming into contact with the immune system.
> =A0The resulting inflammation/autoimmunity can further
> damage angiogenesis and cause nutritional deficiency.
>
> This happens through several routes. =A0In many autoimmune
> gut conditions,=

> butyrate uptake is defective. =A0Without butyrate (and
> enough carnitine to=

> properly metabolize it), you lose the histone acetylation
> you need to make more mucous (via mucin genes). =A0Turns out
> vitamin D3 also needs histone acetylation to make the innate
> antimicrobial peptide cathelicidin which is vital for gut
> barrier function - and it just so happens cathelicidin has
> antiinflammatory/antiallergy properties. =A0 (HIF-1a is a
> crucial intermediary gene in this chain.)
>
> Since symbiotic bacteria living in the gut produce butyrate
> from undigested fiber, you can set this whole ugly process
> in motion by taking antibiotics long enough - especially if
> you combine it with a crappy American diet rich in sugar and
> low in fiber.

Thanks. Three possibilities can be thought; 1. Normal
intestinnal mucus in nature and quantity 2. Excess mucus in
nature(thick or thin) and quantity and 3. lesser mucus in
nature(watery) and quantity.

This may cause, normal and abnormal motility, digestion and
absorptions of food. One one side, there can be normacy
whereas defficiencies or decreased satiety OR excesses on
other side. How it can be related to excessive cravings,
decreased hunger and abnormal digestion, motality and
absorptions in intestines?

[Kofi]

> This may cause, normal and abnormal motility, digestion and
> absorptions of food. One one side, there can be normacy
> whereas defficiencies or decreased satiety OR excesses on
> other side. How it can be related to excessive cravings,
> decreased hunger and abnormal digestion, motality and
> absorptions in intestines?

I think you're asking about how mucous thickness affects the
transit time of food through the gut and how that time affects
feelings of hunger or fullness. The answer is, I haven't
looked at it like that. I do know the mu opioid receptor can
get screwed up in the gut, which is why low-dose naltrexone is
helpful and why morphine affects gut transit time. The mu
opioid receptor is under control of butyrate via HDAC
inhibition and thus under control of probiotics.

Hunger itself is regulated by peptide hormones secreted from
the gut lining running back and forth to the brain. Excess
hunger can be curbed by eliminating part of the gut producing
those hunger signals - i.e., gastric stapling. There's
literally less stomach around to produce hunger signals and
send "feel hungry" signals to the brain after the surgery.

Since I came across research indicating obese people are more
likely to have certain viral infections and another abstract
indicating the existence of autoantibodies to hunger hormones,
it's possible that certain obese patients are simply
autoimmune to their own fullness hormone signals. Guy gets
food-borne virus. Virus shares a protein sequence with leptin
or ghrelin or a PYY. Immune system attacks that sequence to
eliminate the virus but ends up eliminating the "full" signal,
thus causing the poor guy to overeat the very food that has
the virus. Smart strategy for the virus, hell for the
autoimmune guy.

Finally, stress and lack of sleep enhance hunger for sweet,
salty and fatty foods so problems in the HPA stress axis or in
circadian rhythms can affect hunger levels - which isn't
surprising since the central circadian rhythm gene Clock is
also an HDAC inhibitor like butyrate. Mutations in Clock and
elsewhere along the clock pathway can affect general cravings
for a wide range of addictions like cocaine.

[Kumar]

On Mar 24, 3:50=A0pm, Kofi <k...@anon.un> wrote:
> > This may cause, normal and abnormal motility, digestion
> > and absorptions of food. One one side, there can be
> > normacy whereas defficiencies or decreased satiety OR
> > excesses on other side. How it can be related to excessive
> > cravings, decreased hunger and abnormal digestion,
> > motality and absorptions in intestines?
>
> I think you're asking about how mucous thickness affects the
> transit time of food through the gut and how that time
> affects feelings of hunger or fullness. =A0The answer is, I
> haven't looked at it like that. =
=A0I
> do know the mu opioid receptor can get screwed up in the
> gut, which is why low-dose naltrexone is helpful and why
> morphine affects gut transit time. =A0The mu opioid receptor
> is under control of butyrate via HDAC inhibition and thus
> under control of probiotics.

I am also looking at decreased digestion & absorption of all
or few nutrients due to altered mucus resulting decreased
satiety & hunger/ craving to eat more.
> Hunger itself is regulated by peptide hormones secreted from
> the gut lining running back and forth to the brain.
> =A0Excess hunger can be curbed=

> by eliminating part of the gut producing those hunger
> signals - i.e., gastric stapling. =A0There's literally less
> stomach around to produce hunger signals and send "feel
> hungry" signals to the brain after the surgery.
Can't decreased satiety due to decreased absorptions as a
result of altered mucus in intestines also cause more &
**continual hunger?
> Since I came across research indicating obese people are
> more likely to have certain viral infections and another
> abstract indicating the existence of autoantibodies to
> hunger hormones, it's possible that certain obese patients
> are simply autoimmune to their own fullness hormone signals.
> =A0Guy gets food-borne virus. =A0Virus shares a protein
> sequence with leptin or ghrelin or a PYY. =A0Immune system
> attacks that sequence to eliminate the virus but ends up
> eliminating the "full" signal, thus causing the poor guy to
> overeat the very food that has the virus. =A0Smart strategy
> for the virus, hell for the autoimmune guy.
Thanks, this is good research. It may also indicate, a
biochemical abnomality for getting any infection, somewhat
miasma vs. gene theory.

> Finally, stress and lack of sleep enhance hunger for sweet,
> salty and fatty foods so problems in the HPA stress axis or
> in circadian rhythms can affect hunger levels - which isn't
> surprising since the central circadian rhythm gene Clock is
> also an HDAC inhibitor like butyrate. =A0 Mutations in Clock
> and elsewhere along the clock pathway can affect general
> cravings for a wide range of addictions like cocaine.

It is also good findings and may be relevant to modern/big
cities changed life-style with chronic stress, late sleep etc.

Btw, whether it is lack of sleep or late sleep & late getting
up resulting altered light exposures?

[Kofi]

> > I think you're asking about how mucous thickness affects
> > the transit time of food through the gut and how that time
> > affects feelings of hunger or fullness.  The answer is, I
> > haven't looked at it like that.  I do know the mu opioid
> > receptor can get screwed up in the gut, which is why
> > low-dose naltrexone is helpful and why morphine affects
> > gut transit time.  The mu opioid receptor is under control
> > of butyrate via HDAC inhibition and thus under control of
> > probiotics.
>
> I am also looking at decreased digestion & absorption of all
> or few nutrients due to altered mucus resulting decreased
> satiety & hunger/ craving to eat more.

You're interested in the barrier function literature and it's
not primarily focused on mucous so that's not going to get you
very far. You're looking for work on tight gap junction
proteins like zonulin and the recent stuff on HIF-1/vitamin D.
Barrier dysfunction will affect nutritional absorption.
Malnutrition can enhance or lower your appetite depending on
what part of your metabolism takes a hit.

>
> > Finally, stress and lack of sleep enhance hunger for
> > sweet, salty and fatty foods so problems in the HPA stress
> > axis or in circadian rhythms can affect hunger levels -
> > which isn't surprising since the central circadian rhythm
> > gene Clock is also an HDAC inhibitor like butyrate.  
> > Mutations in Clock and elsewhere along the clock pathway
> > can affect general cravings for a wide range of addictions
> > like cocaine.
>
> It is also good findings and may be relevant to
> modern/big cities changed life-style with chronic stress,
> late sleep etc.
>
> Btw, whether it is lack of sleep or late sleep & late
> getting up resulting altered light exposures?

I don't know exactly what you're asking but it's easily
remedied in part by sleeping with something covering your eyes
to minimize your light exposure.

[Marshall P]

Kofi wrote:
>>> I think you're asking about how mucous thickness affects
>>> the transit time of food through the gut and how that time
>>> affects feelings of hunger or fullness. The answer is, I
>>> haven't looked at it like that. I do know the mu opioid
>>> receptor can get screwed up in the gut, which is why
>>> low-dose naltrexone is helpful and why morphine affects
>>> gut transit time. The mu opioid receptor is under control
>>> of butyrate via HDAC inhibition and thus under control of
>>> probiotics.
>> I am also looking at decreased digestion & absorption of
>> all or few nutrients due to altered mucus resulting
>> decreased satiety & hunger/ craving to eat more.
>
> You're interested in the barrier function literature and
> it's not primarily focused on mucous so that's not going to
> get you very far. You're looking for work on tight gap
> junction proteins like zonulin and the recent stuff on
> HIF-1/vitamin D. Barrier dysfunction will affect nutritional
> absorption. Malnutrition can enhance or lower your appetite
> depending on what part of your metabolism takes a hit.
>
>
>>> Finally, stress and lack of sleep enhance hunger for
>>> sweet, salty and fatty foods so problems in the HPA stress
>>> axis or in circadian rhythms can affect hunger levels -
>>> which isn't surprising since the central circadian rhythm
>>> gene Clock is also an HDAC inhibitor like butyrate.
>>> Mutations in Clock and elsewhere along the clock pathway
>>> can affect general cravings for a wide range of addictions
>>> like cocaine.
>> It is also good findings and may be relevant to
>> modern/big cities changed life-style with chronic stress,
>> late sleep etc.
>>
>> Btw, whether it is lack of sleep or late sleep & late
>> getting up resulting altered light exposures?
>
> I don't know exactly what you're asking but it's easily
> remedied in part by sleeping with something covering your
> eyes to minimize your light exposure.

Don't confuse mucus (the noun) with mucous (the adjective).

--
Marshall Price of Miami Known to Yahoo as d021317c

[Kumar]

On Apr 3, 10:53=A0am, Kofi <k...@anon.un.org> wrote:
> > > I think you're asking about how mucous thickness affects
> > > the transit time of food through the gut and how that
> > > time affects feelings of hunger or fullness. =A0The
> > > answer is, I haven't looked at it like that=
. =A0I
> > > do know the mu opioid receptor can get screwed up in the
> > > gut, which is=

> > > why low-dose naltrexone is helpful and why morphine
> > > affects gut transi=
t
> > > time. =A0The mu opioid receptor is under control of
> > > butyrate via HDAC inhibition and thus under control of
> > > probiotics.
>
> > I am also looking at decreased digestion & absorption of
> > all or few nutrients due to altered mucus resulting
> > decreased satiety & hunger/ craving to eat more.
>
> You're interested in the barrier function literature and
> it's not primarily focused on mucous so that's not going to
> get you very far. =A0 You're looking for work on tight gap
> junction proteins like zonulin and the recent stuff on
> HIF-1/vitamin D. =A0Barrier dysfunction will affect
> nutritional absorption. =A0Malnutrition can enhance or lower
> your appetite=

> depending on what part of your metabolism takes a hit.

Yes thanks. What are the usual abnormalities/instabilties
related to barrier dysfunctions in intestines? Why it can't be
mucous instabilties related?
>
>
> > > Finally, stress and lack of sleep enhance hunger for
> > > sweet, salty and fatty foods so problems in the HPA
> > > stress axis or in circadian rhythms=

> > > can affect hunger levels - which isn't surprising since
> > > the central circadian rhythm gene Clock is also an HDAC
> > > inhibitor like butyrate. =
=A0
> > > Mutations in Clock and elsewhere along the clock pathway
> > > can affect general cravings for a wide range of
> > > addictions like cocaine.
>
> > It is also good findings and may be relevant to
> > modern/big cities changed life-style with chronic stress,
> > late sleep etc.
>
> > Btw, whether it is lack of sleep or late sleep & late
> > getting up resulting altered light exposures?
>
> I don't know exactly what you're asking but it's easily
> remedied in part by sleeping with something covering your
> eyes to minimize your light exposure.

I meant, can late sleep and late waking up OR just lack of
sleep is related to above indicated instabilties?

[Kumar]

On Apr 4, 6:40=A0pm, Marshall Price <d0213...@yahoo.com>
wrote:
> Kofi wrote:
> >>> I think you're asking about how mucous thickness affects
> >>> the transit time of food through the gut and how that
> >>> time affects feelings of hunger or fullness. =A0The
> >>> answer is, I haven't looked at it like that=
. =A0I
> >>> do know the mu opioid receptor can get screwed up in the
> >>> gut, which is=

> >>> why low-dose naltrexone is helpful and why morphine
> >>> affects gut transi=
t
> >>> time. =A0The mu opioid receptor is under control of
> >>> butyrate via HDAC inhibition and thus under control of
> >>> probiotics.
> >> I am also looking at decreased digestion & absorption of
> >> all or few nutrients due to altered mucus resulting
> >> decreased satiety & hunger/ craving to eat more.
>
> > You're interested in the barrier function literature and
> > it's not primarily focused on mucous so that's not going
> > to get you very far. =A0=

> > You're looking for work on tight gap junction proteins
> > like zonulin and the recent stuff on HIF-1/vitamin D.
> > =A0Barrier dysfunction will affect nutritional absorption.
> > =A0Malnutrition can enhance or lower your appeti=
te
> > depending on what part of your metabolism takes a hit.
>
> >>> Finally, stress and lack of sleep enhance hunger for
> >>> sweet, salty and fatty foods so problems in the HPA
> >>> stress axis or in circadian rhythms=

> >>> can affect hunger levels - which isn't surprising since
> >>> the central circadian rhythm gene Clock is also an HDAC
> >>> inhibitor like butyrate. =
=A0
> >>> Mutations in Clock and elsewhere along the clock pathway
> >>> can affect general cravings for a wide range of
> >>> addictions like cocaine.
> >> It is also good findings and may be relevant to
> >> modern/big cities changed life-style with chronic stress,
> >> late sleep etc.
>
> >> Btw, whether it is lack of sleep or late sleep & late
> >> getting up resulting altered light exposures?
>
> > I don't know exactly what you're asking but it's easily
> > remedied in part=

> > by sleeping with something covering your eyes to minimize
> > your light exposure.
>
> Don't confuse mucus (the noun) with mucous (the adjective).
>
> --
> Marshall Price of Miami Known to Yahoo as d021317c- Hide
> quoted text -
>
> - Show quoted text -

Thanks. Somotimes this language is bit confusing to
people whose first language was not english. Still, pls
try to manage.