Ironjustic
Wed, Mar-12-08, 17:15
Cheung YF, Chan GC, Ha SY Effect of deferasirox (ICL670) on
arterial function in patients with beta-thalassaemia major.
[JOURNAL ARTICLE] Br J Haematol 2008 Mar 3.
Deferasirox (ICL670) has been shown to have rapid
accessibility to intracellular labile iron. We tested the
hypothesis that oral deferasirox improves arterial dysfunction
in patients with beta-thalassaemia major. Nineteen
thalassaemia patients, aged 23 +/- 7 years, with normal left
ventricular (LV) function were treated with deferasirox at
25-35 mg/kg/ d for 12 months. LV function, brachial arterial
flow-mediated dilation (FMD), carotid arterial stiffness, and
serum ferritin levels were determined at baseline prior to
initiation, after 6 months and after 12 months of therapy. The
baseline cardiovascular indices were compared with those of 17
age- matched controls. Longitudinal changes in patients during
the treatment period were also determined. Compared with
controls, patients had similar echocardiographic indices of LV
function (all P > 0.05), while their baseline brachial FMD was
reduced (P < 0.001) and carotid stiffness increased (P =3D
0.019). An increase in FMD (P < 0.001) and a decrease in
carotid stiffness (P
=3D 0.007) were found at 6 and 12 months follow-up.
The stiffness index correlated inversely with FMD (r =3D
-0.42, P =3D .001). Although there was an increase in ferritin
level at 12 months (3303 +/- 1185 ng/ml vs. 2714 +/- 780 ng/ml
at baseline, P =3D 0.006), no significant correlation existed
between ferritin level and FMD or carotid stiffness. In
conclusion, deferasirox therapy in thalassaemia patients is
associated with improved arterial function.
British journal of haematology [Br J Haematol] --------------
-------------------------------------------------------------
--= =AD-----
MedlinePlus Drug Information: DeferasiroxDeferasirox is used
to remove excess iron that is in the body because of blood
transfusions. Deferasirox is in a class of medications called
iron chelators. ...
www.nlm.nih.gov/medlineplus/druginfo/medmaster/a606002.html
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
arterial function in patients with beta-thalassaemia major.
[JOURNAL ARTICLE] Br J Haematol 2008 Mar 3.
Deferasirox (ICL670) has been shown to have rapid
accessibility to intracellular labile iron. We tested the
hypothesis that oral deferasirox improves arterial dysfunction
in patients with beta-thalassaemia major. Nineteen
thalassaemia patients, aged 23 +/- 7 years, with normal left
ventricular (LV) function were treated with deferasirox at
25-35 mg/kg/ d for 12 months. LV function, brachial arterial
flow-mediated dilation (FMD), carotid arterial stiffness, and
serum ferritin levels were determined at baseline prior to
initiation, after 6 months and after 12 months of therapy. The
baseline cardiovascular indices were compared with those of 17
age- matched controls. Longitudinal changes in patients during
the treatment period were also determined. Compared with
controls, patients had similar echocardiographic indices of LV
function (all P > 0.05), while their baseline brachial FMD was
reduced (P < 0.001) and carotid stiffness increased (P =3D
0.019). An increase in FMD (P < 0.001) and a decrease in
carotid stiffness (P
=3D 0.007) were found at 6 and 12 months follow-up.
The stiffness index correlated inversely with FMD (r =3D
-0.42, P =3D .001). Although there was an increase in ferritin
level at 12 months (3303 +/- 1185 ng/ml vs. 2714 +/- 780 ng/ml
at baseline, P =3D 0.006), no significant correlation existed
between ferritin level and FMD or carotid stiffness. In
conclusion, deferasirox therapy in thalassaemia patients is
associated with improved arterial function.
British journal of haematology [Br J Haematol] --------------
-------------------------------------------------------------
--= =AD-----
MedlinePlus Drug Information: DeferasiroxDeferasirox is used
to remove excess iron that is in the body because of blood
transfusions. Deferasirox is in a class of medications called
iron chelators. ...
www.nlm.nih.gov/medlineplus/druginfo/medmaster/a606002.html
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk