Oxidation In Type 2 Diabetes

[Ironjustic]

"Imbalance between plasma oxidant and antioxidant systems in
type 2 diabetes"

Soliman GZ Blood lipid peroxidation (superoxide dismutase,
malondialdehyde, glutathione) levels in Egyptian type 2
diabetic patients. [Journal Article] Singapore Med J 2008 Feb;
49(2):129-36.

Introduction: The existence of hyperglycaemia produces
increased oxidative stress. The depletion of antioxidants as a
defensive body mechanism may increase the risk of diabetic
complications. Diabetes mellitus is associated with
derangements in the serum levels of several biochemical
parameters, and type 2 diabetes mellitus (or non-
insulin-dependent diabetes mellitus) is a risk factor for
cardiovascular diseases. Methods: Data of 80 control subjects
(male:female, 40:40) and 80 diabetic patients (male:female,
40:40), of similar age, gender, body mass index and duration
of diabetes mellitus (for diabetic group), were collected from
government and non-government organisations during the period,
2001-2004. Blood samples were also collected. Glucose,
glucosylated haemoglobin, total cholesterol (TC), high-density
lipoprotein cholesterol (HDL-C), low-density lipoprotein
cholesterol (LDL-C), very low-density lipoprotein cholesterol
(VLDLC), TC/HDL-C, HDL-C/LDL-C, triacylglycerol,
malondialdehyde, glutathione and superoxide dismutase levels
were determined. Results: Mean cholesterol, LDL-C, VLDL-C and
triacylglycerol levels were significantly higher in patients
with type 2 diabetes mellitus in comparison to the control
subjects, while the mean value of HDL-C was significantly
lower. A significant elevation in malondialdehyde level and
decrease in glutathione content were observed in both male and
female diabetic patients in comparison to the control
subjects. Conclusion: The results suggest that the increase in
lipid peroxidation, and the decline in antioxidant defences,
may appear early in type 2 diabetic patients, before the
development of secondary complications. This phenomenon might
play an important role in the initiation and progression of
diabetic complications. Our results also suggest that there
seems to be an imbalance between plasma oxidant and
antioxidant systems in patients with type 2 diabetes mellitus.

Singapore medical journal [Singapore Med J]

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[Ironjustic]

On Mar 11, 8:27=A0am, "ironjust...@aol.com"
<ironjust...@aol.com> wrote:"Imbalance between plasma oxidant
and antioxidant systems in type 2diabetes" <<

NITRIC OXIDE AND LIPID PEROXIDATION STATUS IN DIABETES
MELLITUS AND HYPERTENSION Khan, Mudassir Ahmad (2000) NITRIC
OXIDE AND LIPID PEROXIDATION STATUS IN DIABETES MELLITUS AND
HYPERTENSION. PhD thesis, University of Karachi, Karachi.

Abstract A total of 246 patients were included in this study,
suffering from diabetes mellitus, or essential hypertension
and those having hypertension in addition to diabetes
mel1itus. 100 healthy persons were also included in the
study, as control subjects. The purpose of study was to
assess the levels of serum nitric oxide and lipid
peroxidation, in these disease states and healthy controls.
And also to compare the serum levels of nitrite, nitrate,
malondialdehyde, and lipid hydroperoxides on the basis of
gender in control healthy subjects. Further to evaluate the
effect on the status of serum nitric oxide and lipid
peroxidation before and after supplementation of vitamin E in
volunteer healthy control subjects and hypertensive patients.
Serum triglycerides, total cholesterol, low-density
lipoprotein cholesterol, very-low-density lipoprotein
cholesterol, malondialdehyde and hydroperoxide levels were
significantly increased in all the groups of patients whereas
high-density lipoprotein cholesterol was' significantly
decreased in contrast to control subjects. A non-significant
increase was observed in levels of nitric oxide metabolites,
i.e., nitrite and nitrate in diabetic patients as compared to
non-diabetic control subjects. On the other hand diabetic
patients with hypertension showed significantly high levels
of nitrite and nitrate as compared to control subjects,
however the levels of these parameters were not significantly
different in diabetics with and without hypertension. Indices
of lipid peroxidation i.e., malondialdehyde and
hydroperoxides were found elevated in non-insulin dependent
diabetics on comparison with insulin dependent diabetic
patients and healthy subjects. No significant difference was
noticed in serum concentrations of nitrite and nitrate, when
insulin- or non-insulin dependent diabetic patients were
compared with control subjects, or when both these types were
compared with each other. Also on the basis of gender
insignificant difference in serum nitrite and nitrate levels,
between control male and female subjects, and a significant
increase in the level of lipid peroxidation indices was
observed in control healthy males as compared to control
healthy female subjects. Supplementation of vitamin E 600 mg
daily for a period of 8 weeks was done in volunteer healthy
controls and hypertensive patients. Results revealed no
significant difference in serum lipids, lipoproteins and
nitric oxide metabolites concentration, whereas a significant
reduction in indices of lipid peroxidation were absented,
before and at the end of supplementation period, in both
volunteer healthy controls and hypertensive patients. It is
thus concluded that diabetes mellitus and essential
hypertension are associated with greater than normal lipid
peroxidation. This increase in oxidative stress may to some
extent, contribute to endothelial dysfunction and reduced
nitric oxide bioavailability in both the disease states. The
effect of vitamin E supplementation in reduction of lipid
peroxidation in both control subjects and hypertensive
patients may provide as a useful measure in protecting
against the deleterious effects of free radicals in health
and disease.

Item Type: Thesis (PhD) Uncontrolled Keywords: nitric oxide,
lipid peroxidation, diabetes mellitus, hypertension, serum
triglycerides, cholesterol, malondialdehyde, hydroperoxide
Subjects: Biological & Medical Sciences (c) > Medical Sciences
(c2) ID Code: 1134 Deposited By: Mr. Muhammad Asif Deposited
On: 03 January 2007

Who loves ya. Tom

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DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

> "Imbalance between plasma oxidant and antioxidant systems in
> =A0type 2diab=
etes"
>
> Soliman GZ Blood lipid peroxidation (superoxide dismutase,
> malondialdehyde, glutathione) levels in Egyptian type 2
> diabetic patients. [Journal Article] Singapore Med J 2008
> Feb; 49(2):129-36.
>
> Introduction: The existence of hyperglycaemia produces
> increased oxidative stress. The depletion of antioxidants as
> a defensive body mechanism may increase the risk of diabetic
> complications.Diabetes mellitus is associated with
> derangements in the serum levels of several biochemical
> parameters, and type 2diabetesmellitus (or non-
> insulin-dependentdiabetesmellitus) is a risk factor for
> cardiovascular diseases. Methods: Data of 80 control
> subjects (male:female, 40:40) and 80 diabetic patients
> (male:female, 40:40), of similar age, gender, body mass
> index and duration ofdiabetesmellitus (for diabetic group),
> were collected from government and non-government
> organisations during the period, 2001-2004. Blood samples
> were also collected. Glucose, glucosylated haemoglobin,
> total cholesterol (TC), high-density lipoprotein cholesterol
> (HDL-C), low-density lipoprotein cholesterol (LDL-C), very
> low-density lipoprotein cholesterol (VLDLC), TC/HDL-C,
> HDL-C/LDL-C, triacylglycerol, malondialdehyde, glutathione
> and superoxide dismutase levels were determined. Results:
> Mean cholesterol, LDL-C, VLDL-C and triacylglycerol levels
> were significantly higher in patients with type
> 2diabetesmellitus in comparison to the control subjects,
> while the mean value of HDL-C was significantly lower. A
> significant elevation in malondialdehyde level and decrease
> in glutathione content were observed in both male and female
> diabetic patients in comparison to the control subjects.
> Conclusion: The results suggest that the increase in lipid
> peroxidation, and the decline in antioxidant defences, may
> appear early in type 2 diabetic patients, before the
> development of secondary complications. This phenomenon
> might play an important role in the initiation and
> progression of diabetic complications. Our results also
> suggest that there seems to be an imbalance between plasma
> oxidant and antioxidant systems in patients with type
> 2diabetesmellitus.
>
> Singapore medical journal [Singapore Med J]
>
> ------------------------------------------------------------
> ---------------=
-=AD-----
>
> Who loves ya. Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk