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Ironjustic
Mon, Mar-10-08, 17:16
"Eliminating detrimental calories found to reduce
oxidative stress"

Public release date: 4-Mar-2008 http://www.eurekalert.org/pub-
_releases/2008-03/ctco-bag030308.php

Contact: Dr. Cesario V. Borlongan cborlongan@mail.mcg.edu
706-733-0188

Cell Transplantation Center of Excellence for Aging and
Brain Repair

Blueberry and green tea containing supplement protects against
stroke damage

Tampa, Florida (March 4, 2008) - A unique dietary supplement
called NutraStem (R) has been shown to have beneficial effects
following experimental stroke. A nutritional supplement
product, NutraStem also known as NT-020, is a proprietary
formulation of blueberry, green tea, vitamin D3 and carnosine
extracts- a combination of nutritional ingredients thought to
be potent in protecting against brain damage.

"Stroke is the third leading cause of death and the leading
cause for disability in the U.S. with two of every 1,000
adults experiencing their firsts stroke in any given year,"
said Cesar V. Borlongan, PhD, of the Medical College of
Georgia, lead author of a study that tested NT-020 post stroke
effects in animal models. "We explored how increasing the
nutritive diet through NT-020 supplementation might render a
therapeutically potent neurogenesis following stroke."

NutraStem was developed by Natura Therapeutics, Inc., based in
Tampa, Florida and founded by neuroscientists from the
University of South Florida.. NutraStem was designed to
encourage the proliferation of adult stem cells, which have
the potential to develop into most tissues and bone cells in
the body and have the capacity to migrate toward problem or
damaged areas.

A study, conducted jointly by scientists at the University
of South Florida College of Medicine (Tampa) and the
Medical College of Georgia (Augusta), examined two groups
of laboratory animals in a double- blind procedure. One
group received the dietary supplement for two weeks prior
to undergoing surgical stroke. The second group did not
receive the dietary supplement. Results, published online
in the high-impact journal REJUVENATION RESEARCH ), showed
that the group receiving NutraStem had greatly reduced
neural damage in the brain and demonstrated significantly
reduced motor deficits.

"The numbers of new neurons found in the damaged brain of the
treated rats was significantly higher," said co-author Paula
Bickford, PhD, of the University of South Florida College of
Medicine and co-founder of Natura Therapeutics, Inc. "An
important feature of our results is that the combination of
agents used was 100 times more potent than previously
published study results that examined each of the individual
ingredients used by themselves."

Co-author Cyndy D. Sanberg, PhD, of Natura Therapeutics, Inc.,
noted that while eliminating detrimental calories has been
found to be protective against stroke by reducing oxidative
stress, the nutritive diet of NutraStem could enhance and
augment that approach.

"Our study found robust neuroprotective effects of the NT-020
formula," said Borlongan. "Two weeks of NutraStem therapy
lessened stroke- induced behavioral deficits, reduced
stroke-induced infarcts and promoted the birth of new neurons.
Our results provide a critical advance in the scientific and
clinical arena by demonstrating the advantage of a multi-agent
over a single agent regimen."

###

Citation: Yasuhara, T., Hara, Koichi, H., Maki, M., Masuda,
T., Sanberg,
C.D., Sanberg, P.R., Bickford, P.C., and Borlongan, C.V.
Dietary supplementation exerts neuroprotective effects in
ischemic stroke model. Rejuvenation Research, 11(1),
2008, 201-214.

Disclosure: Dr. Borlongan is a consultant with Natura
Therapeutics, Inc.

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