New Insights Into Inflammation In Osteoarthritis

[Ironjustic]

I think my free bisphosphonate would be .. good .. here ..
http://tinyurl.com/ypps44

They ARE using bisphosphonates for these "changes in the
entheses" ..

"one their most striking findings was the evidence of changes
in the entheses"

http://tinyurl.com/ytz2t8

New insights into inflammation in osteoarthritis The most
common degenerative joint disease, osteoarthritis (OA) is
marked by the breakdown of articular cartilage, which is the
type of cartilage that lines the ends of most limb bones. It
can afflict any jointfingers, toes, wrists, ankles, elbows,
shoulders, and the spine, as well as the weight-bearing knees
and hips. As OA progresses, sufferers often experience
inflammation around the affected joint. This inflammation has
been attributed to bits of cartilage breaking off and
aggravating the synovium, the thin, smooth membrane lining a
joint. Yet, MRI detection of prominent synovitis in early
OAwhen joint cartilage appears normalsuggests that other joint
structures may be involved in triggering this inflammation.
Recent studies of inflammation in spinal arthritis implicate
the enthesis, which is the attachment site of ligament or
tendon to bone as being a potential driving factor in joint
inflammation.

Intrigued by the potential role of tendon or ligament
attachment sites in synovitis, Professors Michael Benjamin of
Cardiff University and Dennis McGonagle of the University of
Leeds decided to investigate the extent to which different
entheses could contribute to inflammation by forming a
functional unit and destructive partnership with adjacent
synovium. Featured in the November 2007 issue of Arthritis &
Rheumatism
(http://www.interscience.wiley.com/journal/arthritis), their
findings shed light on a potential novel mechanism for
synovial inflammation in degenerative arthritis. This is
based on a structure that the authors have called the
synovial-entheseal complex (SEC). Basically insertions have a
different type of cartilage called fibrocartilage near the
bone. Although this is different from articular cartilage
that lines the ends of bones, the authors speculated that
this type of cartilage could also derive nourishment from
synovium. However, this close integration although desirable
in health could have unfortunate consequences if the enthesis
was damaged.

To validate the widespread formation and to explore further,
the possible inflammatory function of SECs, researchers
collected ligament and tendon attachment samples from 60
cadavers, 35 male and 25 female, with a mean age of 84 years
at death. 49 different entheses19 from the arms, 26 from the
legs, and 4 from the spinal columnwere preserved for
examination. To exclude cartilage degeneration as a trigger
for synovial inflammation, 17 of the selected entheses were
not immediately adjacent to joint cartilage. Each sample was
studied for evidence of inflammatory cells and soft tissue
microdamage, as well as for the composition of SECs.

At 82 percent of the entheses, the formation of a SEC was
found. As expected, this occurred in entheses very close to
joint cartilage, where the synovium was often part of the
joint itself. However, a SEC was also detected in 47 percent
of the sites separated from joint cartilage. For example, the
SEC found at the Achilles tendon was formed with synovium that
protruded from a cavity called a bursa, located a considerable
distance from the ankle joint.

Joint insertions are sites of high mechanical stressing and
the authors speculated that this could lead to damage within
them, including their fibrocartilage This is exactly what the
authors found. Degenerative changesat least one and sometimes
severalwere detected on the soft tissue side of attachment
sites. Most notably, cell clustering and/or fissuring was
found in 76 percent of entheses. In 85 percent of SECs, the
synovial component also showed evidence of mild inflammatory
change. Finally, in 73 percent of the attachments, small
numbers of inflammatory cells were present in the enthesis
itself. Therefore the authors suggest that joint degeneration
of fibrocartilage at insertions could trigger inflammation
within SECs.

As Professors Benjaminand McGonagle note, one their most
striking findings was the large number of attachment sites
with evidence of changes in the entheses mirroring those
typically seen in joint cartilage in OAfibrocartilage cell
clusters, cell hypertrophy, and fissuring among them. Such
changes at certain entheses could be directly relevant to
older subjects with joint symptoms due to degenerative
disease, Professor McGonagle observes, and some of the
symptoms could be emanating from the SEC.

Affirming the concept of a synovio-etheseal complex as widely
applicable at many sites in the body, both right next to and
removed from joint cartilage, this study also supports the
idea that biomechanical factors related to the enthesis could
play an important role in synovial inflammation in both
degenerative and inflammatory arthritis.

Contact: Amy Molnar amolnar@wiley.com John Wiley & Sons, Inc.
Source:Eurekalert

----------------------------------------

Bisphosphonates reduce bone mineral loss at ligament entheses
after joint injury. Osteoarthritis and Cartilage, Volume 13,
Issue 9, Pages 790-797
M. Doschak, J. LaMothe, D. Cooper, B. Hallgrimsson, D. Hanley,
R. Bray, R. Zernicke

http://www.thefinalsprint.com/tag/stress-fracture/

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[Ironjustic]

On Mar 8, 2:37=A0am, "Ray" <rayd...@hotmail.com>
wrote:Healthcare professionals should consider whether
bisphosphonate use might be responsible for severe
musculoskeletal pain in patients who present with these
symptoms and consider temporary or permanent discontinuation
of the drug <<

Bisphosphonates have been used with VERY good success. The
FACT so many bisphosphonates HAVE been created ATTESTS to the
NEED .. for .. the bisphosphonates .. ?

Evidence based medicine .. ?

Then since the bishosphonates seem to be REPLACING and/or
standing IN for 'something' .. might make one think then the
.. standing in they ARE .. doing IS .. for .. the chaff of our
grain / the phytate in our foods .. ?

That is based on the chemical makeup OF the bisphosphonates ..
the phosphate groups which are KNOWN to chelate iron .. and
iron chelators are accomplishing the SAME thing .. bone growth
and/or relief of bone pain .. ?

Gumshoeing ..

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

> "ironjustice" <teamtan...@hotmail.com> wrote in message
>
> news:a2993da1-5234-46b3-a1d8-8e9202f82514@e25g2000prg.googl-
> egroups.com...
>
>
>
>
>
> >I think my free bisphosphonate would be .. good .. here ..
> >http://tinyurl.com/ypps44
>
> > They ARE using bisphosphonates for these "changes in the
> > entheses" ..
>
> > "one their most striking findings was the evidence of
> > changes in the entheses"
>
> >http://tinyurl.com/ytz2t8
>
> > New insights into inflammation in osteoarthritis The most
> > common degenerative joint disease, osteoarthritis (OA) is
> > marked by the breakdown of articular cartilage, which is
> > the type of cartilage that lines the ends of most limb
> > bones. It can afflict any jointfingers, toes, wrists,
> > ankles, elbows, shoulders, and the spine, as well as the
> > weight-bearing knees and hips. As OA progresses, sufferers
> > often experience inflammation around the affected joint.
> > This inflammation has been attributed to bits of cartilage
> > breaking off and aggravating the synovium, the thin,
> > smooth membrane lining a joint. Yet, MRI detection of
> > prominent synovitis in early OAwhen joint cartilage
> > appears normalsuggests that other joint structures may be
> > involved in triggering this inflammation. Recent studies
> > of inflammation in spinal arthritis implicate the
> > enthesis, which is the attachment site of ligament or
> > tendon to bone as being a potential driving factor in
> > joint inflammation.
>
> > Intrigued by the potential role of tendon or ligament
> > attachment sites in synovitis, Professors Michael Benjamin
> > of Cardiff University and Dennis McGonagle of the
> > University of Leeds decided to investigate the extent to
> > which different entheses could contribute to inflammation
> > by forming a functional unit and destructive partnership
> > with adjacent synovium. Featured in the November 2007
> > issue of Arthritis & Rheumatism
> > (http://www.interscience.wiley.com/journal/arthritis),
> > their findings shed light on a potential novel mechanism
> > for synovial inflammation in degenerative arthritis. This
> > is based on a structure that the authors have called the
> > synovial-entheseal complex (SEC). Basically insertions
> > have a different type of cartilage called fibrocartilage
> > near the bone. Although this is different from articular
> > cartilage that lines the ends of bones, the authors
> > speculated that this type of cartilage could also derive
> > nourishment from synovium. However, this close integration
> > although desirable in health could have unfortunate
> > consequences if the enthesis was damaged.
>
> > To validate the widespread formation and to explore
> > further, the possible inflammatory function of SECs,
> > researchers collected ligament and tendon attachment
> > samples from 60 cadavers, 35 male and 25 female, with a
> > mean age of 84 years at death. 49 different entheses19
> > from the arms, 26 from the legs, and 4 from the spinal
> > columnwere preserved for examination. To exclude cartilage
> > degeneration as a trigger for synovial inflammation, 17 of
> > the selected entheses were not immediately adjacent to
> > joint cartilage. Each sample was studied for evidence of
> > inflammatory cells and soft tissue microdamage, as well as
> > for the composition of SECs.
>
> > At 82 percent of the entheses, the formation of a SEC was
> > found. As expected, this occurred in entheses very close
> > to joint cartilage, where the synovium was often part of
> > the joint itself. However, a SEC was also detected in 47
> > percent of the sites separated from joint cartilage. For
> > example, the SEC found at the Achilles tendon was formed
> > with synovium that protruded from a cavity called a bursa,
> > located a considerable distance from the ankle joint.
>
> > Joint insertions are sites of high mechanical stressing
> > and the authors speculated that this could lead to damage
> > within them, including their fibrocartilage This is
> > exactly what the authors found. Degenerative changesat
> > least one and sometimes severalwere detected on the soft
> > tissue side of attachment sites. Most notably, cell
> > clustering and/or fissuring was found in 76 percent of
> > entheses. In 85 percent of SECs, the synovial component
> > also showed evidence of mild inflammatory change. Finally,
> > in 73 percent of the attachments, small numbers of
> > inflammatory cells were present in the enthesis itself.
> > Therefore the authors suggest that joint degeneration of
> > fibrocartilage at insertions could trigger inflammation
> > within SECs.
>
> > As Professors Benjaminand McGonagle note, one their most
> > striking findings was the large number of attachment sites
> > with evidence of changes in the entheses mirroring those
> > typically seen in joint cartilage in OAfibrocartilage cell
> > clusters, cell hypertrophy, and fissuring among them. Such
> > changes at certain entheses could be directly relevant to
> > older subjects with joint symptoms due to degenerative
> > disease, Professor McGonagle observes, and some of the
> > symptoms could be emanating from the SEC.
>
> > Affirming the concept of a synovio-etheseal complex as
> > widely applicable at many sites in the body, both right
> > next to and removed from joint cartilage, this study also
> > supports the idea that biomechanical factors related to
> > the enthesis could play an important role in synovial
> > inflammation in both degenerative and inflammatory
> > arthritis.
>
> > Contact: Amy Molnar amol...@wiley.com John Wiley & Sons,
> > Inc. Source:Eurekalert
>
> > ----------------------------------------
>
> > Bisphosphonates reduce bone mineral loss at ligament
> > entheses after joint injury. Osteoarthritis and Cartilage,
> > Volume 13, Issue 9, Pages 790-797
> > M. Doschak, J. LaMothe, D. Cooper, B. Hallgrimsson, D.
> > Hanley, R. Bray, R. Zernicke
>
> >http://www.thefinalsprint.com/tag/stress-fracture/
>
> > Who loves ya. Tom
>
> > Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
>
> > Man Is A Herbivore!
> > http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKING
> > http://tinyurl.com/zk9fk
>
> Bisphosphonates (marketed as Actonel, Actonel+Ca, Aredia,
> Boniva, Didronel=
,
> Fosamax, Fosamax+D, Reclast, Skelid, and Zometa)
>
> Audience: Orthopedic Surgeons, other healthcare providers,
> patients [Posted 01/07/2008] FDA informed healthcare
> professionals and patients of the possibility of severe and
> sometimes incapacitating bone, joint, and/or=

> muscle (musculoskeletal) pain in patients taking
> bisphosphonates. Although=

> severe musculoskeletal pain is included in the prescribing
> information for=

> all bisphosphonates, the association between bisphosphonates
> and severe musculoskeletal pain may be overlooked by
> healthcare professionals, delayi=
ng
> diagnosis, prolonging pain and/or impairment, and
> necessitating the use of=

> analgesics. The severe musculoskeletal pain may occur within
> days, months,=

> or years after starting a bisphosphonates. Some patients
> have reported complete relief of symptoms after
> discontinuing the bisphosphonate, wherea=
s
> others have reported slow or incomplete resolution. The risk
> factors for a=
nd
> incidence of severe musculoskeletal pain associated with
> bisphosphonates a=
re
> unknown.
>
> Healthcare professionals should consider whether
> bisphosphonate use might =
be
> responsible for severe musculoskeletal pain in patients who
> present with these symptoms and consider temporary or
> permanent discontinuation of the drug.- Hide quoted text -
>
> - Show quoted text -

[Mr-Natural]

Do you mind repeating that in plain English, please.

[Ironjustic]

On Mar 9, 10:14=A0am, Mr-Natural-Health <john-h-
go...@naturalhealthperspective.com> wrote: Do you mind
repeating that in plain English, please. <<

The substance / drugs they have created **synthetically** they
call bisphosphonates and have been used extensively because
they work.

They are expensive drugs / substances .. these
bisphosphonates.

The chemical makeup of the drugs are very similar to a natural
substance .. natural meaning .. "found in nature".

This substance is found in the food you eat.

It is called phytate.

It can be called a bisphosphonate because they have put it up
against the same diseases versus another bisphosphonate That
is combined with its chemical makeup.

The drugs / substances they created synthetically are causing
major problems and they are now taking them away from you.

These drugs can now be replaced by the natural bisphosphonate
phyate found in your food.

It is a matter now of which drugs / substances they created
synthetically are responsible for the ill effects or is it all
bisphosphonates INCLUDING your food ?

I would tend to think they screwed up .. creation .. as
opposed to creation .. screwing .. up.

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[Marshall P]

Ray wrote:
> "ironjustice" <teamtanner@hotmail.com> wrote in message new-
> s:a2993da1-5234-46b3-a1d8-8e9202f82514@e25g2000prg.googlegr-
> oups.com...
>> I think my free bisphosphonate would be .. good .. here ..
>> http://tinyurl.com/ypps44
>>
>> They ARE using bisphosphonates for these "changes in the
>> entheses" ..
>>
>> "one their most striking findings was the evidence of
>> changes in the entheses"
>>
>> http://tinyurl.com/ytz2t8
>>
>> New insights into inflammation in osteoarthritis The most
>> common degenerative joint disease, osteoarthritis (OA) is
>> marked by the breakdown of articular cartilage, which is
>> the type of cartilage that lines the ends of most limb
>> bones. It can afflict any jointfingers, toes, wrists,
>> ankles, elbows, shoulders, and the spine, as well as the
>> weight-bearing knees and hips. As OA progresses, sufferers
>> often experience inflammation around the affected joint.
>> This inflammation has been attributed to bits of cartilage
>> breaking off and aggravating the synovium, the thin, smooth
>> membrane lining a joint. Yet, MRI detection of prominent
>> synovitis in early OAwhen joint cartilage appears
>> normalsuggests that other joint structures may be involved
>> in triggering this inflammation. Recent studies of
>> inflammation in spinal arthritis implicate the enthesis,
>> which is the attachment site of ligament or tendon to bone
>> as being a potential driving factor in joint inflammation.
>>
>> Intrigued by the potential role of tendon or ligament
>> attachment sites in synovitis, Professors Michael Benjamin
>> of Cardiff University and Dennis McGonagle of the
>> University of Leeds decided to investigate the extent to
>> which different entheses could contribute to inflammation
>> by forming a functional unit and destructive partnership
>> with adjacent synovium. Featured in the November 2007 issue
>> of Arthritis & Rheumatism
>> (http://www.interscience.wiley.com/journal/arthritis),
>> their findings shed light on a potential novel mechanism
>> for synovial inflammation in degenerative arthritis. This
>> is based on a structure that the authors have called the
>> synovial-entheseal complex (SEC). Basically insertions have
>> a different type of cartilage called fibrocartilage near
>> the bone. Although this is different from articular
>> cartilage that lines the ends of bones, the authors
>> speculated that this type of cartilage could also derive
>> nourishment from synovium. However, this close integration
>> although desirable in health could have unfortunate
>> consequences if the enthesis was damaged.
>>
>> To validate the widespread formation and to explore
>> further, the possible inflammatory function of SECs,
>> researchers collected ligament and tendon attachment
>> samples from 60 cadavers, 35 male and 25 female, with a
>> mean age of 84 years at death. 49 different entheses19 from
>> the arms, 26 from the legs, and 4 from the spinal
>> columnwere preserved for examination. To exclude cartilage
>> degeneration as a trigger for synovial inflammation, 17 of
>> the selected entheses were not immediately adjacent to
>> joint cartilage. Each sample was studied for evidence of
>> inflammatory cells and soft tissue microdamage, as well as
>> for the composition of SECs.
>>
>> At 82 percent of the entheses, the formation of a SEC was
>> found. As expected, this occurred in entheses very close to
>> joint cartilage, where the synovium was often part of the
>> joint itself. However, a SEC was also detected in 47
>> percent of the sites separated from joint cartilage. For
>> example, the SEC found at the Achilles tendon was formed
>> with synovium that protruded from a cavity called a bursa,
>> located a considerable distance from the ankle joint.
>>
>> Joint insertions are sites of high mechanical stressing and
>> the authors speculated that this could lead to damage
>> within them, including their fibrocartilage This is exactly
>> what the authors found. Degenerative changesat least one
>> and sometimes severalwere detected on the soft tissue side
>> of attachment sites. Most notably, cell clustering and/or
>> fissuring was found in 76 percent of entheses. In 85
>> percent of SECs, the synovial component also showed
>> evidence of mild inflammatory change. Finally, in 73
>> percent of the attachments, small numbers of inflammatory
>> cells were present in the enthesis itself. Therefore the
>> authors suggest that joint degeneration of fibrocartilage
>> at insertions could trigger inflammation within SECs.
>>
>> As Professors Benjaminand McGonagle note, one their most
>> striking findings was the large number of attachment sites
>> with evidence of changes in the entheses mirroring those
>> typically seen in joint cartilage in OAfibrocartilage cell
>> clusters, cell hypertrophy, and fissuring among them. Such
>> changes at certain entheses could be directly relevant to
>> older subjects with joint symptoms due to degenerative
>> disease, Professor McGonagle observes, and some of the
>> symptoms could be emanating from the SEC.
>>
>> Affirming the concept of a synovio-etheseal complex as
>> widely applicable at many sites in the body, both right
>> next to and removed from joint cartilage, this study also
>> supports the idea that biomechanical factors related to the
>> enthesis could play an important role in synovial
>> inflammation in both degenerative and inflammatory
>> arthritis.
>>
>> Contact: Amy Molnar amolnar@wiley.com John Wiley & Sons,
>> Inc. Source:Eurekalert
>>
>> ----------------------------------------
>>
>> Bisphosphonates reduce bone mineral loss at ligament
>> entheses after joint injury. Osteoarthritis and Cartilage,
>> Volume 13, Issue 9, Pages 790-797
>> M. Doschak, J. LaMothe, D. Cooper, B. Hallgrimsson, D.
>> Hanley, R. Bray, R. Zernicke
>>
>>
>> http://www.thefinalsprint.com/tag/stress-fracture/
>>
>>
>> Who loves ya. Tom
>>
>>
>> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
>>
>>
>> Man Is A Herbivore! http://tinyurl.com/a3cc3
>>
>>
>> DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
>>
>>
>
> Bisphosphonates (marketed as Actonel, Actonel+Ca, Aredia,
> Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid,
> and Zometa)
>
> Audience: Orthopedic Surgeons, other healthcare providers,
> patients [Posted 01/07/2008] FDA informed healthcare
> professionals and patients of the possibility of severe and
> sometimes incapacitating bone, joint, and/or muscle
> (musculoskeletal) pain in patients taking bisphosphonates.
> Although severe musculoskeletal pain is included in the
> prescribing information for all bisphosphonates, the
> association between bisphosphonates and severe
> musculoskeletal pain may be overlooked by healthcare
> professionals, delaying diagnosis, prolonging pain and/or
> impairment, and necessitating the use of analgesics. The
> severe musculoskeletal pain may occur within days, months,
> or years after starting a bisphosphonates. Some patients
> have reported complete relief of symptoms after
> discontinuing the bisphosphonate, whereas others have
> reported slow or incomplete resolution. The risk factors for
> and incidence of severe musculoskeletal pain associated with
> bisphosphonates are unknown.
>
> Healthcare professionals should consider whether
> bisphosphonate use might be responsible for severe
> musculoskeletal pain in patients who present with these
> symptoms and consider temporary or permanent discontinuation
> of the drug.

This reminded me of a brief article I found in "Science News,"
v 173, p 101, February 16, 2008: "Swell, a Pain Lesson." It
says that we have intestinal flora to thank for our ability to
feel pain and experience inflammation throughout our bodies.
It's probably available at http://www.sciencenews.org

It occurs to me that the bisphosphonates might increase pain
and inflammation (whether for good or ill) by affecting the
microbes in our intestines.

--
Marshall Price of Miami Known to Yahoo as d021317c