PDA

View Full Version : Extra two stones boosts risk of cancer


Welcome to the Active Low-Carber Forums

Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!



Demi
Fri, Feb-15-08, 03:31
The Telegraph
London, UK
15 February, 2008


Extra two stones boosts risk of cancer

1 stone = 14lb

The chance of developing five different types of cancer increases by 50 per cent if your weight goes up by more than two stones, according to new research.

A study at the University of Manchester found that those who put on weight equivalent to a five-point increase in the body mass index (BMI) were at significant risk of contracting cancer of the colon, breast, skin, thyroid.

The increase in BMI is equivalent to two-and-a-half stones (18.9kg) for a healthy man of average height, 5ft 9ins (1.75m), and almost two stones (12.6kg) for a healthy woman of average height, 5ft 4ins (1.63m).

Men who gained that amount of weight were 50 per cent more likely to develop oesophageal cancer and a third more likely to suffer thyroid cancer. Their chances of getting colon and kidney cancer increase by 24 per cent; they are also at a smaller but significant risk of rectal and skin cancer.

Women who are similarly overweight increase their chances of cancer of the womb lining and gallbladder by 59 per cent. They also have more than a 50 per cent increased risk of oesophageal cancer and are a third more likely to develop kidney cancer.

The chances of women getting pancreatic, thyroid, and colon cancer increased significantly if they were overweight, but were not as great as the risk for men.

The findings, published in the medical journal The Lancet, come at a time when more than one in four Britons are classed as obese and there are fears of an epidemic of weight related health problems.

The research shows that both sexes were also more at risk of leukaemia, multiple melanoma, a cancer of the blood cells, and non-Hodgkin lymphoma.

The team at Manchester University studied almost 300,000 cases involving 20 different types of cancer to determine the effect of a five-point increase in BMI.

A person's BMI is calculated by dividing weight in kilograms by height in metres squared. Scientists classify a person as overweight if they have a BMI of between 25 and 29.9, and as obese if the BMI is more than 30.

http://www.telegraph.co.uk/news/graphics/2008/02/15/ncancer115big.gif

Dr Andrew G Renehan, of the University of Manchester Christie Hospital NHS Foundation Trust, who led the study, said it showed "increased BMI is associated with an increased risk of several cancers in adults".

He recommended that scientists consider the differing rates of risk between the sexes to discover what links obesity and cancer.

Dr Colin Waine, chairman of the National Obesity Forum, said the findings were "very alarming". He said scientists had known of the association between obesity and cancers of the womb lining, breast, colon, kidney and gullet but had not known the extent of the link. "We mainly think of obesity alongside diabetes and cardiometabolic disease but it is clear now that the risk of cancer needs to be treated just as seriously," he said.

Ed Yong, from Cancer Research, said the research showed the importance of maintaining a healthy diet and taking exercise. He said: "After avoiding smoking, maintaining a healthy body weight is one of the most important steps we can all take to reduce our risk of cancer."

Last year, a similar study linked obesity with six major cancers.

http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2008/02/15/ncancer115.xml

Zuleikaa
Fri, Feb-15-08, 07:14
Probably because vitamin D gets trapped in adipose tissue and is not bioavailable to the body. The obese may require 2-3 times the amount of vitamin D as a normal weight individual because of this. Vitamin D protects from cancer.

moggsy
Fri, Feb-15-08, 07:42
It could also be that the stuff that we eat that tends to make us fat could also lead to cancer (not discounting the vitamin D idea either).

Zei
Sat, Feb-16-08, 17:24
Probably weight gain is a marker of other problems going on inside the body, too, like metabolic/insulin problems that may associate with or cause cancer.

LarryAJ
Sat, Feb-16-08, 19:06
OR, it could be as simple as "cancer can ONLY use glucose as fuel, SO having high blood glucose is like feeding gasoline to a fire." Thus high blood glucose from too much carbohydrate in the diet, both causes weight/fat gain AND also allows any cancers that start to grow uninhibited. The cancer glucose (sugar) connection is the subject of this web page (http://www.lowcarbluxury.com/newsletter/lclnewsvol03-no04-pg2.html). In it there is a reference to a research article (http://www.pnas.org/cgi/content/full/95/4/1511) which says at the end of the Introduction. Tumor cells characteristically maintain a high glycolytic rate even under aerobic conditions, a phenomenon recognized by Warburg (17) and subsequently by Crabtree (18) seven decades ago. Because glucose levels are limited by diffusion into spheroid clusters of tumor cells (19), which are characterized by high aerobic glycolysis rates, we sought to determine whether glucose deprivation may play a role in regulating the growth of c-Myc-transformed cells and found that c-Myc transformed cells undergo apoptotic cell death with glucose deprivation. Note what I have made bold. Of course NO money can be made by just telling cancer victims to stop eating ALL carbohydrates, if indeed that would work. BUT, that seems to be what happened to my prostate cancer.

deirdra
Sun, Feb-17-08, 08:29
My sister, who was chubby from age 5 to 40, got breast cancer at 45, after reaching and maintaining a normal weight on a low-fat high-carb diet. So obesity didn't cause the cancer. It is more likely that what normally causes obesity (high carb intake driving high insulin levels) is what feeds the cancer cells.

My aunt (by marriage), who was chubby from 15-60, got pancreatic cancer 5 years after she started eating more 'healthfully' - low-fat high-carb, margarine, not butter, etc. (before that she was a butter and other real food-eating 1950's style cook). Everyone I know who has died from pancreatic cancer was an avid food pyramid-following 'healthy eater' who made sure they got 65% carbs/day. Coincidence?

Nancy LC
Sun, Feb-17-08, 11:20
It could also be that the stuff that we eat that tends to make us fat could also lead to cancer (not discounting the vitamin D idea either).
That's what the first 2 sections in Taubes book are about. :)