Removing Iron Prevents Cancer Drug Toxicity

[Ironjustic]

<<snip>> Analog of the metal chelator EDTA that likely acts by
removing iron <<snip>>

Expert Opin Investig Drugs. 2008 Feb;17(2):217-23. Links The
use of dexrazoxane for the prevention of anthracycline
extravasation injury.Hasinoff BB. Faculty of Pharmacy,
University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
B_Hasinoff@UManitoba.ca

BACKGROUND: The use of the anthracycline anticancer drugs
doxorubicin, daunorubicin, epirubicin and idarubicin sometimes
results in accidental extravasation injury and can be a
serious complication of their use. OBJECTIVE: The object of
this review was to evaluate the preclinical and clinical
literature on the use of dexrazoxane in preventing
anthracycline- induced extravasation injury. METHODS: A review
of the literature was carried out using PubMed.
RESULTS/CONCLUSIONS: Dexrazoxane, which is clinically used to
reduce doxorubicin-induced cardiotoxicity, has been shown in
two clinical studies and in several case reports to be highly
efficacious in preventing anthracycline- induced extravasation
injury. Dexrazoxane is a prodrug analog of the metal chelator
EDTA that likely acts by removing iron from the iron-
anthracycline complex, thus preventing formation of damaging
reactive oxygen species.

PMID: 18230055 [PubMed - in process]

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[Ironjustic]

On Feb 1, 10:14 am, ironjustice <teamtan...@hotmail.com>
wrote: likely acts by removing iron from the iron-
anthracycline complex <<

Sooo .. it makes one wonder .. since the anthracyclines
seem to .. complex .. **iron** .. what would happen if they
used a substance which binds iron .. **efficiently** the
FIRST .. time .. ?

They use crappy drugs to bind iron inefficiently .. and send
in ANOTHER iron binder to .. FINALLY .. bind up the rest of
the iron .. the first drug / anthracyclines.. could NOT
efficiently bind up .. ?

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

> <<snip>> Analog of the metal chelator EDTA that likely acts
> by removing iron <<snip>>
>
> Expert Opin Investig Drugs. 2008 Feb;17(2):217-23. Links The
> use of dexrazoxane for the prevention of anthracycline
> extravasation injury.Hasinoff BB. Faculty of Pharmacy,
> University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
> B_Hasin...@UManitoba.ca
>
> BACKGROUND: The use of the anthracycline anticancer drugs
> doxorubicin, daunorubicin, epirubicin and idarubicin
> sometimes results in accidental extravasation injury and can
> be a serious complication of their use. OBJECTIVE: The
> object of this review was to evaluate the preclinical and
> clinical literature on the use of dexrazoxane in preventing
> anthracycline- induced extravasation injury. METHODS: A
> review of the literature was carried out using PubMed.
> RESULTS/CONCLUSIONS: Dexrazoxane, which is clinically used
> to reduce doxorubicin-induced cardiotoxicity, has been shown
> in two clinical studies and in several case reports to be
> highly efficacious in preventing anthracycline- induced
> extravasation injury. Dexrazoxane is a prodrug analog of the
> metal chelator EDTA that likely acts by removing iron from
> the iron- anthracycline complex, thus preventing formation
> of damaging reactive oxygen species.
>
> PMID: 18230055 [PubMed - in process]
>
> Who loves ya. Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

[Ironjustic]

On Feb 2, 10:54=A0am, ironjustice <teamtan...@hotmail.com>
wrote: what would happen if they used a substance which binds
iron .. **efficiently** the FIRST .. time .. ? <<

"IP6 has the potential for adenocarcinoma"

Oncol Rep. 2008 Feb;19(2):563-6. Links Corn-derived
carbohydrate inositol hexaphosphate inhibits Barrett's
adenocarcinoma growth by pro-apoptotic mechanisms. McFadden
DW, Riggs DR, Jackson BJ, Cunningham C. Department of Surgery,
Robert C. Byrd Health Science Center, West Virginia
University, Morgantown, WV 26506, USA.
david.mcfad...@vtmednet.org.

Inositol hexaphosphate (IP6) is a naturally occurring
polyphosphorylated carbohydrate that is found in food sources
high in fiber content. IP6 has been reported to have
significant inhibitory effects against a variety of primary
tumors. We hypothesized that IP6 would inhibit the cell growth
rate of Barrett's adenocarcinoma in vitro. Two
Barrett's-associated adenocarcinoma cell lines, SEG-1 and
BIC-1, were treated with IP6 at 0.5, 1.0 and 5.0 mM
concentrations. Cell viability was measured by MTT assay.
Apoptosis and necrosis were evaluated by the Annexin V FITC
assay. Reductions (P<0.001) in cellular proliferation were
observed in both cell lines. IP6 decreased late apoptosis and
necrosis in BIC cells, whereas in SEG-1 cells, early
apoptosis, late apoptosis and necrosis were all increased by
IP6. IP6 decreases cellular growth by pro-apoptotic
mechanisms. Our findings suggest that IP6 has the
potential to become an effective adjunct for Barrett's
adenocarcinoma. Further studies are needed to evaluate
safety and clinical utility of this agent in patients
with Barrett's adenocarcinoma.

PMID: 18202808 [PubMed - in process]

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

> On Feb 1, 10:14 am, ironjustice <teamtan...@hotmail.com>
> wrote: likely acts by removing iron from the iron-
> anthracycline complex <<
>
> Sooo .. it makes one wonder .. since the anthracyclines seem
> to .. complex .. **iron** .. what would happen if they used
> a substance which binds iron .. **efficiently** the FIRST ..
> time .. ?
>
> They use crappy drugs to bind iron inefficiently .. and send
> in ANOTHER iron binder to .. FINALLY .. bind up the rest of
> the iron .. the first drug / anthracyclines.. could NOT
> efficiently bind up .. ?
>
> Who loves ya. Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > <<snip>> Analog of the metal chelator EDTA that likely
> > acts by removing iron <<snip>>
>
> > Expert Opin Investig Drugs. 2008 Feb;17(2):217-23. Links
> > The use of dexrazoxane for the prevention of anthracycline
> > extravasation injury.Hasinoff BB. Faculty of Pharmacy,
> > University of Manitoba, Winnipeg, Manitoba R3T 2N2,
> > Canada. B_Hasin...@UManitoba.ca
>
> > BACKGROUND: The use of the anthracycline anticancer drugs
> > doxorubicin, daunorubicin, epirubicin and idarubicin
> > sometimes results in accidental extravasation injury and
> > can be a serious complication of their use. OBJECTIVE: The
> > object of this review was to evaluate the preclinical and
> > clinical literature on the use of dexrazoxane in
> > preventing anthracycline- induced extravasation injury.
> > METHODS: A review of the literature was carried out using
> > PubMed. RESULTS/CONCLUSIONS: Dexrazoxane, which is
> > clinically used to reduce doxorubicin-induced
> > cardiotoxicity, has been shown in two clinical studies and
> > in several case reports to be highly efficacious in
> > preventing anthracycline- induced extravasation injury.
> > Dexrazoxane is a prodrug analog of the metal chelator EDTA
> > that likely acts by removing iron from the iron-
> > anthracycline complex, thus preventing formation of
> > damaging reactive oxygen species.
>
> > PMID: 18230055 [PubMed - in process]
>
> > Who loves ya. Tom
>
> > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted
> > text -
>
> - Show quoted text -