Taka
Fri, Feb-01-08, 05:16
Lipids. 1997 May;32(5):535-41.
Lipid peroxidation during n-3 fatty acid and vitamin E
supplementation in humans.
Allard JP, Kurian R, Aghdassi E, Muggli R, Royall D.
Department of Medicine, University of Toronto, Ontario,
Canada.
The purpose of this study was to investigate in healthy humans
the effect of eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA) intake, alone or in combination with
dL-alpha-tocopherol acetate (vitamin E) supplements on lipid
peroxidation. Eighty men were randomly assigned in a
double-blind fashion to take daily for 6 wk either menhaden
oil (6.26 g, n-3 fatty acids) or olive oil supplements with
either vitamin E (900 IU) or its placebo. Antioxidant
vitamins, phospholipid composition, malondialdehyde (MDA), and
lipid peroxides were measured in the plasma at baseline and
week 6. At the same time, breath alkane output was measured.
Plasma alpha-tocopherol concentration increased in those
receiving vitamin E (P < 0.0001). In those supplemented with
n-3 fatty acids, EPA and DHA increased in plasma phospholipids
(P < 0.0001) and plasma MDA and lipid peroxides increased (P <
0.001 and P < 0.05, respectively). Breath alkane output did
not change significantly and vitamin E intake did not prevent
the increase in lipid peroxidation during menhaden oil
supplementation. The results demonstrate that supplementing
the diet with n-3 fatty acids resulted in an increase in lipid
peroxidation, as measured by plasma MDA release and lipid
peroxide products, which was not suppressed by vitamin E
supplementation. PMID: 9168460
neither statins will save you - even this Pharma-sponsored
study admires that fish oil creates more peroxides:
Eur J Clin Nutr. 2003 Jun;57(6):793-800.
Increased lipid peroxidation during long-term intervention
with high doses of n-3 fatty acids (PUFAs) following an acute
myocardial infarction.
Grundt H, Nilsen DW, Mansoor MA, Nord=F8y A. Department of
Clinical Chemistry, Central Hospital in Rogaland, POB 8100,
4068 Stavanger, Norway.
OBJECTIVE: To assess the oxidative burden of a highly
concentrated compound of n-3 PUFAs as compared to corn oil by
measuring thiobarbituric acid-malondialdehyde complex
(TBA-MDA) by HPLC. We also studied the influence on TBA-MDA of
statins combined with n-3 PUFAs or corn oil. DESIGN: A
prospective, randomised, double-blind, controlled study.
SETTING: One hospital centre in Stavanger, Norway. SUBJECTS: A
total of 300 subjects with an acute myocardial infarction
(MI). INTERVENTIONS: Gelatine capsules, containing 850-882 mg
EPA and DHA as concentrated ethylesters, or 1 g of corn oil,
were ingested in a dose of two capsules twice a day for at
least 1 y. Alpha-tocopherol (4 mg) was added to all capsules
to protect the PUFAs against oxidation. RESULTS: After 1 y
TBA-MDA increased modestly in the n-3 PUFA group (n=3D125), as
compared to the corn oil group (n=3D130), P=3D0.027. Multiple
linear regression analyses of fatty acids in serum total
phospholipids (n=3D56) on TBA-MDA measured after 12 months
intervention, showed no dependency. Performing best subsets
regression, serum phospholipid concentration of arachidonic
acid (20:4 n-6 PUFA) was identified as a predictor of TBA-MDA
at 12 months follow-up, P=3D0.004.We found no impact of
statins on TBA-MDA. CONCLUSION: TBA-MDA increased modestly
after long-term intervention with n-3 PUFAs compared to corn
oil post- MI, suggesting biological changes induced by n-3
PUFAs, rather than simply reflecting their concentration
differences. The peroxidative potential of n-3 PUFAs was not
modified by statin treatment. SPONSORSHIP:: Pharmacia A/S and
Pronova A/S, Norway. PMID: 12792664
The only thing which greatly boosts the antioxidant defenses
and can protect you is CR or the low carb regime.
Taka
Lipid peroxidation during n-3 fatty acid and vitamin E
supplementation in humans.
Allard JP, Kurian R, Aghdassi E, Muggli R, Royall D.
Department of Medicine, University of Toronto, Ontario,
Canada.
The purpose of this study was to investigate in healthy humans
the effect of eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA) intake, alone or in combination with
dL-alpha-tocopherol acetate (vitamin E) supplements on lipid
peroxidation. Eighty men were randomly assigned in a
double-blind fashion to take daily for 6 wk either menhaden
oil (6.26 g, n-3 fatty acids) or olive oil supplements with
either vitamin E (900 IU) or its placebo. Antioxidant
vitamins, phospholipid composition, malondialdehyde (MDA), and
lipid peroxides were measured in the plasma at baseline and
week 6. At the same time, breath alkane output was measured.
Plasma alpha-tocopherol concentration increased in those
receiving vitamin E (P < 0.0001). In those supplemented with
n-3 fatty acids, EPA and DHA increased in plasma phospholipids
(P < 0.0001) and plasma MDA and lipid peroxides increased (P <
0.001 and P < 0.05, respectively). Breath alkane output did
not change significantly and vitamin E intake did not prevent
the increase in lipid peroxidation during menhaden oil
supplementation. The results demonstrate that supplementing
the diet with n-3 fatty acids resulted in an increase in lipid
peroxidation, as measured by plasma MDA release and lipid
peroxide products, which was not suppressed by vitamin E
supplementation. PMID: 9168460
neither statins will save you - even this Pharma-sponsored
study admires that fish oil creates more peroxides:
Eur J Clin Nutr. 2003 Jun;57(6):793-800.
Increased lipid peroxidation during long-term intervention
with high doses of n-3 fatty acids (PUFAs) following an acute
myocardial infarction.
Grundt H, Nilsen DW, Mansoor MA, Nord=F8y A. Department of
Clinical Chemistry, Central Hospital in Rogaland, POB 8100,
4068 Stavanger, Norway.
OBJECTIVE: To assess the oxidative burden of a highly
concentrated compound of n-3 PUFAs as compared to corn oil by
measuring thiobarbituric acid-malondialdehyde complex
(TBA-MDA) by HPLC. We also studied the influence on TBA-MDA of
statins combined with n-3 PUFAs or corn oil. DESIGN: A
prospective, randomised, double-blind, controlled study.
SETTING: One hospital centre in Stavanger, Norway. SUBJECTS: A
total of 300 subjects with an acute myocardial infarction
(MI). INTERVENTIONS: Gelatine capsules, containing 850-882 mg
EPA and DHA as concentrated ethylesters, or 1 g of corn oil,
were ingested in a dose of two capsules twice a day for at
least 1 y. Alpha-tocopherol (4 mg) was added to all capsules
to protect the PUFAs against oxidation. RESULTS: After 1 y
TBA-MDA increased modestly in the n-3 PUFA group (n=3D125), as
compared to the corn oil group (n=3D130), P=3D0.027. Multiple
linear regression analyses of fatty acids in serum total
phospholipids (n=3D56) on TBA-MDA measured after 12 months
intervention, showed no dependency. Performing best subsets
regression, serum phospholipid concentration of arachidonic
acid (20:4 n-6 PUFA) was identified as a predictor of TBA-MDA
at 12 months follow-up, P=3D0.004.We found no impact of
statins on TBA-MDA. CONCLUSION: TBA-MDA increased modestly
after long-term intervention with n-3 PUFAs compared to corn
oil post- MI, suggesting biological changes induced by n-3
PUFAs, rather than simply reflecting their concentration
differences. The peroxidative potential of n-3 PUFAs was not
modified by statin treatment. SPONSORSHIP:: Pharmacia A/S and
Pronova A/S, Norway. PMID: 12792664
The only thing which greatly boosts the antioxidant defenses
and can protect you is CR or the low carb regime.
Taka