Ironjustic
Fri, Dec-21-07, 06:15
"Chelators as anti-cancer agents is warranted"
Green Tea Kills Breast Cancer Cells by Lisa Frazier
12/20/2007 BETHESDA, Md.--Scientists at the
UniformedServicesUniversity of the Health Sciences
(USU), Bethesda, Md., investigated green tea and its
anti-tumor effects in breast cancer cells. The recently
concluded study will be published in the Journal of
Cancer Biology and Therapy, December 2007.
Results from the study suggested green tea inhibited the
invading capacity of breast cancer cells, while also
identifying mechanisms involved in destroying cancer cells.
http://www.naturalproductsinsider.com/hotnews/7ch2083910-
92383.html
----------------------------------------------------------
Hemoglobin. 2006;30(2):311-27. Related Articles, Links
Iron-chelating and free-radical scavenging activities of
microwave-processed green tea in iron overload.
Srichairatanakool S, Ounjaijean S, Thephinlap C, Khansuwan U,
Phisalpong C, Fucharoen S.
Department of Biochemistry, Faculty of Medicine, Chiang Mai
University, Thailand. md...@yahoo.com
Secondary iron overload is found in beta-thalassemia (thal)
patients because of increased dietary iron absorption and
multiple blood transfusions. Excessive iron catalyzes
free-radical generation, leading to oxidative damage and vital
organ dysfunction. Non-transferrin-bound iron (NTBI) detected
in thalassemic plasma is highly toxic and chelatable. Though
used to treat iron overload, desferrioxamine (DFO) and
deferiprone (L1) also have adverse effects. Green tea (GT)
shows many pharmacological effects, particularly antioxidative
and iron-chelating capacities. This study was performed to
investigate the ability of GT extracts to reduce plasma NTBI
concentration and oxidative stress in vitro. The Fe(3+) was
found to bind to GT crude extract and form a complex. Green
tea crude extract time- and dose-dependently decreased plasma
NTBI concentration and counteracted the increase of oxidative
stress in both Fe(2+)-EDTA-treated human plasma and
erythrocytes. Green tea is a bifunctional natural product that
could be relevant for management of iron overload and
oxidative stress.
PMID: 16798656 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
--------------------
Crit Rev Oncol Hematol 2002 Jun;42(3):267-81
Iron chelators as therapeutic agents for the treatment
of cancer.
Richardson DR The Iron Metabolism and Chelation Group, The
Heart Research Institute, 145 Missenden Road, Camperdown,
2050, Sydney, NSW, Australia
[Medline record in process]
A wide variety of studies in vitro, in vivo, and in clinical
trials have demonstrated that the chelator currently used to
treat iron overload disease, desferrioxamine, has
anti-proliferative effects against both leukemia and
neuroblastoma. However, the efficacy of desferrioxamine is
severely limited due to its poor ability to permeate cell
membranes and chelate intracellular iron pools. These studies
have led to the development of other iron chelators that are
far more effective than desferrioxamine. Some of these
chelators such as 3-aminopyridine-2-carboxaldehyde
thiosemicarbazone (Triapine(R)) have entered phase I clinical
trials, while other chelators such as
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone or
tachpyridine require evaluation in animal models. The high
anti-tumor activity observed with these ligands certainly
suggests further development of chelators as anti-cancer
agents is warranted.
PMID: 12050019, UI: 22045182
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Green Tea Kills Breast Cancer Cells by Lisa Frazier
12/20/2007 BETHESDA, Md.--Scientists at the
UniformedServicesUniversity of the Health Sciences
(USU), Bethesda, Md., investigated green tea and its
anti-tumor effects in breast cancer cells. The recently
concluded study will be published in the Journal of
Cancer Biology and Therapy, December 2007.
Results from the study suggested green tea inhibited the
invading capacity of breast cancer cells, while also
identifying mechanisms involved in destroying cancer cells.
http://www.naturalproductsinsider.com/hotnews/7ch2083910-
92383.html
----------------------------------------------------------
Hemoglobin. 2006;30(2):311-27. Related Articles, Links
Iron-chelating and free-radical scavenging activities of
microwave-processed green tea in iron overload.
Srichairatanakool S, Ounjaijean S, Thephinlap C, Khansuwan U,
Phisalpong C, Fucharoen S.
Department of Biochemistry, Faculty of Medicine, Chiang Mai
University, Thailand. md...@yahoo.com
Secondary iron overload is found in beta-thalassemia (thal)
patients because of increased dietary iron absorption and
multiple blood transfusions. Excessive iron catalyzes
free-radical generation, leading to oxidative damage and vital
organ dysfunction. Non-transferrin-bound iron (NTBI) detected
in thalassemic plasma is highly toxic and chelatable. Though
used to treat iron overload, desferrioxamine (DFO) and
deferiprone (L1) also have adverse effects. Green tea (GT)
shows many pharmacological effects, particularly antioxidative
and iron-chelating capacities. This study was performed to
investigate the ability of GT extracts to reduce plasma NTBI
concentration and oxidative stress in vitro. The Fe(3+) was
found to bind to GT crude extract and form a complex. Green
tea crude extract time- and dose-dependently decreased plasma
NTBI concentration and counteracted the increase of oxidative
stress in both Fe(2+)-EDTA-treated human plasma and
erythrocytes. Green tea is a bifunctional natural product that
could be relevant for management of iron overload and
oxidative stress.
PMID: 16798656 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
--------------------
Crit Rev Oncol Hematol 2002 Jun;42(3):267-81
Iron chelators as therapeutic agents for the treatment
of cancer.
Richardson DR The Iron Metabolism and Chelation Group, The
Heart Research Institute, 145 Missenden Road, Camperdown,
2050, Sydney, NSW, Australia
[Medline record in process]
A wide variety of studies in vitro, in vivo, and in clinical
trials have demonstrated that the chelator currently used to
treat iron overload disease, desferrioxamine, has
anti-proliferative effects against both leukemia and
neuroblastoma. However, the efficacy of desferrioxamine is
severely limited due to its poor ability to permeate cell
membranes and chelate intracellular iron pools. These studies
have led to the development of other iron chelators that are
far more effective than desferrioxamine. Some of these
chelators such as 3-aminopyridine-2-carboxaldehyde
thiosemicarbazone (Triapine(R)) have entered phase I clinical
trials, while other chelators such as
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone or
tachpyridine require evaluation in animal models. The high
anti-tumor activity observed with these ligands certainly
suggests further development of chelators as anti-cancer
agents is warranted.
PMID: 12050019, UI: 22045182
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk