Nancy LC
Sat, Dec-08-07, 23:02
Another great article from Dr. McCleary.
http://www.drmccleary.com/Default.aspx#a229057ec-a766-484b-ace3-cb1b6abe96c1
Snippet: As such, it appears there is a link between obesity, AD and the nose brain. The question might be asked, what is its substrate. Clues to this exist. Numerous investigators have identified decreased insulin signaling in the brains of patients with AD. This has been documented in numerous animal models of AD. In addition, when insulin levels in the brain are evaluated, they are lower in AD than in age equivalent normals. AD patients are frequently found to be insulin resistant. This means their bodies don't react normally to the hormonal effects of insulin. Insulin is the hormone that regulates and controls blood sugar levels. With a diminished response to insulin, blood sugar levels rise and higher insulin levels are needed to bring them back to normal. As insulin levels rise in the bloodstream, they fall in the brain. One reason for this is that insulin in the blood can't be as effectively transported to the brain because of modifications in the blood-brain-barrier (BBB). Animals with lowered brain insulin develop mental decline and memory loss. In short, they become demented.
http://www.drmccleary.com/Default.aspx#a229057ec-a766-484b-ace3-cb1b6abe96c1
Snippet: As such, it appears there is a link between obesity, AD and the nose brain. The question might be asked, what is its substrate. Clues to this exist. Numerous investigators have identified decreased insulin signaling in the brains of patients with AD. This has been documented in numerous animal models of AD. In addition, when insulin levels in the brain are evaluated, they are lower in AD than in age equivalent normals. AD patients are frequently found to be insulin resistant. This means their bodies don't react normally to the hormonal effects of insulin. Insulin is the hormone that regulates and controls blood sugar levels. With a diminished response to insulin, blood sugar levels rise and higher insulin levels are needed to bring them back to normal. As insulin levels rise in the bloodstream, they fall in the brain. One reason for this is that insulin in the blood can't be as effectively transported to the brain because of modifications in the blood-brain-barrier (BBB). Animals with lowered brain insulin develop mental decline and memory loss. In short, they become demented.