Sumatriptan and Gabapentin For High Altitude Headache

[Ironjustic]

These drugs work for headaches in altitude sickness ..
coincidentally also used for seizures which ALSO occur at
altitude. The headaches at altitude are caused by increased
red blood cell production / polycythemia which is hallmarked
by .. headache. Sooo .. is it the viscosity of the blood and /
or erythrocytosis .. ?

Ann Neurol. 2007 Sep;62(3):273-7. Links Sumatriptan for
prevention of acute mountain sickness: randomized clinical
trial. Jafarian S, Gorouhi F, Salimi S, Lotfi J. Department of
Neurology, Shariati Hospital, Tehran University of Medical
Sciences, and Iranian Center of Neurological Sciences, Medical
Sciences-University of Tehran, Tehran, Iran.
jafarian_s@yahoo.com

OBJECTIVE: To determine the impact of sumatriptan prophylaxis
on acute mountain sickness (AMS) and altitude headache
development within 24 hours of ascent, we designed a
double-blind, randomized, clinical trial. METHODS: A
prospective, double-blind, randomized, placebo-controlled
trial was conducted in Tochal Mountain Hotel at an altitude of
3,500 meters above sea level during October 2006 to November
2006. A total of 102 Iranian adults were assigned to receive
either sumatriptan succinate
(50mg) or placebo within 1 hour of ascent. AMS incidence was
measured by Lake Louise AMS score > or = 3 with
headache and one other symptom. Secondary outcome
measures included severity of syndrome (Lake Louise
scores > or = 5), incidence of headache, and severity
of headache. RESULTS: Based on intention-to-treat
analysis, AMS was more prevalent in placebo group (n =
23 [45.1%]) than sumatriptan group (n = 12 [23.5%]; p =
0.02). Headache also had a greater rate for placebo
users (placebo vs sumatriptan group: 29 [56.9%] vs 17
[33.3%]; p = 0.02). No association was detected between
sumatriptan prophylaxis and AMS or altitude headache
severity. DISCUSSION: Sumatriptan prophylaxis is
effective to prevent AMS development. Furthermore, our
findings confirm cerebral vasodilative and edematous
mechanisms of AMS progression, whereas sumatriptan is a
selective 5- hydroxytryptamine(1) receptor subtype
agonist and a selective cerebral vasoconstrictor as a
result (http://www.controlled-trials.com/
ISRCTN87201238/).

PMID: 17557349 [PubMed - in process]
-------------------------------------------

J Neurol Neurosurg Psychiatry. 2007 Oct 26; [Epub ahead of
print] Links Gabapentin for prevention of hypobaric
hypoxia-induced headache: Randomized double-blind clinical
trial. Jafarian S, Abolfazli R, Gorouhi F, Rezaie S, Lotfi J.
Department of Neurology, Shariati Hospital, Medical Sciences/
University of Tehran, Iran, Islamic Republic of.

BACKGROUND: High-altitude headache (HAH) is a hypobaric
hypoxia-induced symptom which is commonly experienced by
newcomers to high-altitude areas. OBJECTIVE: To assess the
efficacy of gabapentin in prevention of HAH. METHODS: A
placebo-controlled randomized trial was performed at an
altitude of 3500 meters. Two hundred and four unacclimatized
15 to 65 years old (mean age[A+/-SD], 31.5A+/-11.7) hotel
guests were randomly assigned to a 600mg single-dose of
gabapentin capsule or identical placebo. HAH incidence and
intensity were measured to assess gabapentin efficacy.
Intention to treat analysis was performed. RESULTS: The
incidence of HAH was not significantly different between
subjects under gabapentin (44[43.1%]) compared with placebo
(56[54.9%]; Neuro=0.09). In contrast, moderate/severe HAH had
lower incidence in gabapentin group (27[26.5%) versus placebo
group (42[41.2%]) showing that gabapentin reduced HAH attack
intensity (Neuro=0.03). CONCLUSIONS: Gabapentin was effective
for prevention of HAH and had satisfactory tolerability.
(controlled-trials.com identifier:ISRCTN26123577).

PMID: 17965148 [PubMed - as supplied by publisher]

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[ferrous]

With the death of the iron causes all disease and the birth of
the altitude causes all disease notion, how does this post fit
into the over all picture?

Jesus lived near the world's lowest altitude.

Jesus ate a mediterranean diet.

[Ironjustic]

>> On Nov 5, 6:40 am, ferr...@paris.com wrote:
With the death of the iron causes all disease and the birth
of the altitude causes all disease notion, how does this post
fit into the over all picture? <<

You don't .. know .. ?

Didn't I just explain it .. ?

Didn't I just explain it .. specifically .. to **YOU** .. ?

Didn't I .. ?

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[ferrous]

With the death of the iron causes all disease notion and the
birth of the altitude causes all disease notion, how does this
post fit into the over all picture?

Jesus lived near the world's lowest altitude.

Jesus ate a mediterranean diet.

[Ironjustic]

>> On Nov 5, 12:42 pm, ferr...@paris.com wrote:
how does this post fit into theover all picture? <<

Didn't I just explain it .. ?

Didn't I just explain it .. specifically .. to **YOU** .. ?

Didn't I .. ?

And here you are .. doing your best impression of .. work.

You'll make a good medical professional ..

Does no work .. and when you do .. do .. work .. ?

You kill kids ..

I guess logic would tell me to .. continue to DO your work
for you . ?

Yep ..

That would be the .. manly .. thing to do .. ?

What am I asking YOU .. for ..

Heh .. heh ..

Now once .. again ..

ARE you .. prepared .. ?

Altitude sickness .. manifests increased red blood cell
production .. hemochromatosis. It is a **human model** of
hemochromatosis .. one GETS hemochromatosis / iron overload
when one goes to altitude.

Sooo .. if I want to study someone who HAS erythrocytosis /
hemochromatosis I just go to .. altitude ..

I will find the same disease .. at sea level .. in people who
have .. hemochromatosis / iron overload.

Altitude sickness and hemochromatosis are the same ..
disease ..

That must be where you are .. blowing it ..

You don't seem to be able to grasp that ..

Now .. I wonder why that is .. ?

Stupidity .. ?

Can't be .. ignorance .. HAS to be stupidity ..

Because .. ? I've explained it to you numerous .. times.

Altitude sickness is .. hemochromatosis.

Altitude sickness has another name .. hemochromatosis ..

NON-**genetic** hemochromatosis .. secondary
hemochromatosis ..

Secondary hemochromatosis is .. iron overload which is not
related at all to .. genetics ..

**Hereditary** hemochromatosis is .. genetic .. thusly ..
appropriately .. CALLED .. ? .. called .. ?

H-E-R-E-D-I-T-A-R-Y .. iron overload / hemochromatosis /
erythrocytosis / polycythemia.

The sheer number of different names for the same condition
might be what is throwing you off .. ?

Too .. hard .. for .. ya .. ?

And that gives evidence to the fact you should not be IN ..
science ..

You are not cut out for it ..

ANYTHING can be learned if someone tries hard enough .. though
..

So to make it easy for you to find this post again so you can
refer back to it .. often .. to refresh your memory .. I will
leave a word in this post so you can search with this word to
FIND this specific thread / explanation.

I'll make up a word just for you ..

Braindeadferrous.

Using that search word .. you should be able to find this
explanation .. again .. quite .. easily ..

Search the google groups with your .. special .. word and you
will always be able to find this post .. again.. for a
refresher ..

OK .. ?

Good ..

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk