Lecithin Versus Steroids in Ulcerative Colitis

[Ironjustic]

"80% of phosphatidylcholine recipients discontinued
steroid therapy "

Ann Intern Med. 2007 Nov 6;147(9):603-610. Phosphatidylcholine
for Steroid-Refractory Chronic Ulcerative Colitis: A
Randomized Trial.Stremmel W, Ehehalt R, Autschbach F, Karner
M. University Hospital Heidelberg, Heidelberg, Germany.

BACKGROUND: Although long-term steroid treatment is
discouraged in ulcerative colitis, alternatives are lacking
when therapy with immunosuppressant drugs fails. An
insufficient level of phosphatidylcholine in colonic mucus is
a possible pathogenetic factor for ulcerative colitis.
OBJECTIVE: To see whether steroid withdrawal is easier with
retarded-release phosphatidylcholine or placebo in adults with
chronic steroid- refractory ulcerative colitis. DESIGN:
Randomized, double-blind, placebo-controlled trial conducted
from March 2003 to January 2006. SETTING: University Hospital
Heidelberg, a referral center for inflammatory bowel disease.
PATIENTS: 60 patients with chronic steroid-refractory
ulcerative colitis and high clinical and endoscopic disease
activity indexes (score >/=5). INTERVENTION:
Phosphatidylcholine or cellulose placebo was ingested 4 times
daily for 12 weeks for a total dosage of 2 g/d. The follow-up
rate was 97%. MEASUREMENTS: The number of patients achieving
complete steroid withdrawal and either a low clinical activity
index (</=3) or improvement in the clinical activity index of
50% or more. RESULTS: The primary end point was achieved in 15
of 30 (50%) phosphatidylcholine recipients and in 3 of 30
(10%) placebo recipients (difference, 40% [95% CI, 19% to
61%]; P = 0.002). Twenty-four phosphatidylcholine recipients
(80%) and 3 (10%) placebo recipients discontinued steroid
therapy without disease exacerbation (difference, 70% [CI, 52%
to 88%]; P <0.001). Mild bloating was a common adverse event.
Limitations: The sample size was small, and the study was of
short duration. CONCLUSION: Phosphatidylcholine reduced
corticosteroid dependence more than placebo in patients with
chronic steroid-refractory ulcerative colitis. The next step
is long-term trials to evaluate the sustainability of steroid
withdrawal in these patients. ClinicalTrials.gov registration
number: NCT00259545.

PMID: 17975182 [PubMed - as supplied by publisher]

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[Ironjustic]

>> On Nov 3, 8:42 am, ironjustice
>> <ironjust...@cashette.com> wrote:
"80% of phosphatidylcholine recipients discontinued steroid
therapy " <<

http://tinyurl.com/ypatx8

Herbals & Supplements Phosphatidylcholine What is it?
Phosphatidylcholine is found in soy lecithin. It can be taken
as dietary lecithin or as a supplement for high cholesterol,
atherosclerosis (fat deposits on arteries), high blood
pressure, liver problems, bipolar depression, dementia,
dyskinesias (difficulty making movements), gallbladder
disease, headache, and multiple sclerosis. It is used on the
skin for acne and psoriasis.

Other names for Phosphatidylcholine include: Lecithin,
Phosphatidylethanolamine, Phosphatidyl, Phosphatidylinositol,
PC-55, Ethanolamine, and Serine.

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

>
> Ann Intern Med. 2007 Nov 6;147(9):603-610.
> Phosphatidylcholine for Steroid-Refractory Chronic
> Ulcerative Colitis: A Randomized Trial.Stremmel W, Ehehalt
> R, Autschbach F, Karner M. University Hospital Heidelberg,
> Heidelberg, Germany.
>
> BACKGROUND: Although long-term steroid treatment is
> discouraged in ulcerative colitis, alternatives are lacking
> when therapy with immunosuppressant drugs fails. An
> insufficient level of phosphatidylcholine in colonic mucus
> is a possible pathogenetic factor for ulcerative colitis.
> OBJECTIVE: To see whether steroid withdrawal is easier with
> retarded-release phosphatidylcholine or placebo in adults
> with chronic steroid- refractory ulcerative colitis. DESIGN:
> Randomized, double-blind, placebo-controlled trial conducted
> from March 2003 to January 2006. SETTING: University
> Hospital Heidelberg, a referral center for inflammatory
> bowel disease. PATIENTS: 60 patients with chronic
> steroid-refractory ulcerative colitis and high clinical and
> endoscopic disease activity indexes (score >/=5).
> INTERVENTION: Phosphatidylcholine or cellulose placebo was
> ingested 4 times daily for 12 weeks for a total dosage of 2
> g/d. The follow-up rate was 97%. MEASUREMENTS: The number of
> patients achieving complete steroid withdrawal and either a
> low clinical activity index (</=3) or improvement in the
> clinical activity index of 50% or more. RESULTS: The primary
> end point was achieved in 15 of 30 (50%) phosphatidylcholine
> recipients and in 3 of 30 (10%) placebo recipients
> (difference, 40% [95% CI, 19% to 61%]; P = 0.002).
> Twenty-four phosphatidylcholine recipients (80%) and 3 (10%)
> placebo recipients discontinued steroid therapy without
> disease exacerbation (difference, 70% [CI, 52% to 88%]; P
> <0.001). Mild bloating was a common adverse event.
> Limitations: The sample size was small, and the study was of
> short duration. CONCLUSION: Phosphatidylcholine reduced
> corticosteroid dependence more than placebo in patients with
> chronic steroid-refractory ulcerative colitis. The next step
> is long-term trials to evaluate the sustainability of
> steroid withdrawal in these patients. ClinicalTrials.gov
> registration number: NCT00259545.
>
> PMID: 17975182 [PubMed - as supplied by publisher]
>
> Who loves ya. Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

[Ironjustic]

On Nov 3, 9:23 am, Wayne Marsh <waynegma...@mac.com> wrote:But
in what concentration? <<

The full text would say what type of phosphatidylcholine they
used. They HAVE been using a special high concentrated form in
other studies so one has to wonder. Others have pointed out
that fact and how it would take quite a bit of regular
lecithin to get THAT specific dose OF that specific lipid. In
horses it seems to work straight up lecithin but they added
some pectin so some might argue the pectin had some effect but
it was simply lecithin they used in the horses.

**In three of the horses the gastric ulcerations had healed
completely, and in six others the lesions had improved
significantly.**

Vet Rec. 2003 May 31;152(22):679-81. Related Articles, Links

Treatment of gastric ulceration in 10 standardbred racehorses
with a pectin-lecithin complex.

Ferrucci F, Zucca E, Croci C, Di Fabio V, Ferro E.

Institute of Veterinary Internal Medicine, Faculty of
Veterinary Medicine, University of Milan, via Celoria 10,
20133 Milan, Italy.

The severity of the erosive and ulcerative lesions of the
squamous gastric mucosa in 10 standardbred racehorses in
training was classified according to a standard scoring
system. Each horse was then treated orally for 30 days with 50
g/100 kg bodyweight daily of a pectin-lecithin complex mixed
into the feed. At the end of the period of treatment, the
gastric lesions were re- evaluated gastroscopically and the
scores were compared with those assigned at the previous
evaluation. In three of the horses the gastric ulcerations
had healed completely, and in six others the lesions had
improved significantly.

PMID: 12803394 [PubMed - in process]

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

> ironjustice wrote on 11/3/07 11:05 AM:
>
> > Phosphatidylcholine is found in soy lecithin.
>
> But in what concentration? How much soy lecithin would you
> have to eat to get the 2 grams/day of phosphatidylcholine
> used in the clinical study? One kilogram/day? Ten kilos/day?
>
> Wayne Marsh Minneapolis, Minnesota, USA
> waynegma...@mac.com

[Ironjustic]

On Nov 3, 9:23 am, Wayne Marsh <waynegma...@mac.com> wrote:
But in what concentration? How much soy lecithin would you
have to eat to<<

This is some stuff a guy said his doctor told him to take ..
it seems to sound like the stuff they were using ..

http://nutrasalpharmaceuticals.stores.yahoo.net/phoscho-
l9001.html

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

> get the 2 grams/day of phosphatidylcholine used in the
> clinical study? One kilogram/day? Ten kilos/day?
>
> Wayne Marsh Minneapolis, Minnesota, USA
> waynegma...@mac.com

[Wayne Mars]

ironjustice wrote on 11/3/07 11:05 AM:

> Phosphatidylcholine is found in soy lecithin.

But in what concentration? How much soy lecithin would you
have to eat to get the 2 grams/day of phosphatidylcholine used
in the clinical study? One kilogram/day? Ten kilos/day?

Wayne Marsh Minneapolis, Minnesota, USA
waynegmarsh@mac.com

[Vernono O]

"Wayne Marsh" <waynegmarsh@mac.com> wrote in message
news:C3520A96.600C3%waynegmarsh@mac.com...
> ironjustice wrote on 11/3/07 11:05 AM:
>
>> Phosphatidylcholine is found in soy lecithin.
>
> But in what concentration? How much soy lecithin would you
> have to eat to get the 2 grams/day of phosphatidylcholine
> used in the clinical study? One kilogram/day? Ten kilos/day?
>
> Wayne Marsh Minneapolis, Minnesota, USA
> waynegmarsh@mac.com
>

Two table spoons of Lecithin "granules" will provide
approximately 2.3 grams of phosphatidylcholine.

It also raises HDL (good) and if taken with other food causes
fats to be passed through.

[zumone2002]

Hello Wayne,

Wayne Marsh wrote:
> ironjustice wrote on 11/3/07 11:05 AM:
>
> > Phosphatidylcholine is found in soy lecithin.
>
> But in what concentration? How much soy lecithin would you
> have to eat to get the 2 grams/day of phosphatidylcholine
> used in the clinical study? One kilogram/day? Ten kilos/day?

And what coating? The primary researcher has done
similar work before using a patented (by the
researcher IIRC) retarded release form of
phosphatidylcholine. Which makes sense if they are
trying to have it released in the colon and not
absorbed in the small intestine.

See " Retarded release phosphatidylcholine benefits
patients with chronic active ulcerative colitis"
(http://www.ncbi.nlm.nih.gov/sites/ entrez? Db=pubmed-
&Cmd=ShowDetailView&TermToSearch=15951544&ordinalpos=-
1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa-
nel.Pubmed_RVAbstractPlus)

Eggs are another dietary source for it. From the old
PDRHealth.com entry: " Lecithins containing
phosphatidylcholine are produced from vegetable,
animal and microbial sources, but mainly from
vegetable sources. Soybean, sunflower and rapeseed are
the major plant sources of commercial lecithin.
Soybean is the most common source. Plant lecithins are
considered to be GRAS (generally regarded as safe).
Egg yolk lecithin is not a major source of lecithin in
nutritional supplements. Eggs themselves naturally
contain from 68 to 72% phosphatidylcholine, while soya
contains from 20 to 22% phosphatidylcholine."

--
Luke

[Vernono O]

"Beez" <beasdg@yahoo.com> wrote in message
news:1194133984.835116.278430@v3g2000hsg.googlegroups.com...
> I've been using it for quite a while, it's called Phoschol.
> 900mg PPC per capsule. I take 3 capsules per day. It's kind
> of expensive though.
>
> Dave
>
Real lecithin doesn't come in capsules. Anything other than
granules has been processed further.

[Beez]

On Nov 3, 8:21 pm, "Vernono O" <Here @there> wrote:
> Real lecithin doesn't come in capsules. Anything other than
> granules has been processed further.

It isn't lecithin, it's Polyenylphosphatidylcholine.
It's a much more concentrated form of
phosphatidylcholine than lecithin.