Ironjustic
Fri, Nov-02-07, 17:16
BRAIN
Quantitative Assessment of Iron Accumulation in the Deep
Gray Matter of Multiple Sclerosis by Magnetic Field
Correlation Imaging
Y. Gea, J.H. Jensena, H. Lua, J.A. Helperna, L. Milesa,
M. Inglesea,
Y.A. Babba, J. Herbertb and R.I. Grossmana a Center for
Biomedical Imaging, Department of Radiology, New York
University Medical Center, New York, NY b Department of
Neurology, MS Care Center, Hospital for Joint Diseases,
New York University School of Medicine, New York, NY
Please address correspondence to Yulin Ge, MD, Department of
Radiology/ Center for Biomedical Imaging, New York University
School of Medicine, 650 First Ave, 6th Floor, Room 615, New
York, NY 10016; e-mail: yulin.ge@med.nyu.edu
BACKGROUND AND PURPOSE: Deposition of iron has been recognized
recently as an important factor of pathophysiologic change
including neurodegenerative processes in multiple sclerosis
(MS). We propose that there is an excess accumulation of iron
in the deep gray matter in patients with MS that can be
measured with a newly developed quantitative MR
technique-magnetic field correlation (MFC) imaging.
MATERIALS AND METHODS: With a 3T MR system, we studied 17
patients with relapsing-remitting MS and 14 age-matched
healthy control subjects. We acquired MFC imaging using an
asymmetric single-shot echo- planar imaging sequence. Regions
of interest were selected in both deep gray matter and white
matter regions, and the mean MFC values were compared between
patients and controls. We also correlated the MFC data with
lesion load and neuropsychologic tests in the patients.
RESULTS: MFC measured in the deep gray matter in patients with
MS was significantly higher than that in the healthy controls
(P .03), with an average increase of 24% in the globus
pallidus, 39.5% in the putamen, and 30.6% in the thalamus. The
increased iron deposition measured with MFC in the deep gray
matter in the patients correlated positively with the total
number of MS lesions (thalamus: r = 0.61, P
= .01; globus pallidus: r = 0.52, P = .02). A moderate but
= significant
correlation between the MFC value in the deep gray matter and
the neuropsychologic tests was also found.
CONCLUSION: Quantitative measurements of iron content with MFC
demonstrate increased accumulation of iron in the deep gray
matter in patients with MS, which may be associated with the
disrupted iron outflow pathway by lesions. Such abnormal
accumulation of iron may contribute to neuropsychologic
impairment and have implications for neurodegenerative
processes in MS.
http://www.ajnr.org/cgi/content/full/28/9/1639
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Quantitative Assessment of Iron Accumulation in the Deep
Gray Matter of Multiple Sclerosis by Magnetic Field
Correlation Imaging
Y. Gea, J.H. Jensena, H. Lua, J.A. Helperna, L. Milesa,
M. Inglesea,
Y.A. Babba, J. Herbertb and R.I. Grossmana a Center for
Biomedical Imaging, Department of Radiology, New York
University Medical Center, New York, NY b Department of
Neurology, MS Care Center, Hospital for Joint Diseases,
New York University School of Medicine, New York, NY
Please address correspondence to Yulin Ge, MD, Department of
Radiology/ Center for Biomedical Imaging, New York University
School of Medicine, 650 First Ave, 6th Floor, Room 615, New
York, NY 10016; e-mail: yulin.ge@med.nyu.edu
BACKGROUND AND PURPOSE: Deposition of iron has been recognized
recently as an important factor of pathophysiologic change
including neurodegenerative processes in multiple sclerosis
(MS). We propose that there is an excess accumulation of iron
in the deep gray matter in patients with MS that can be
measured with a newly developed quantitative MR
technique-magnetic field correlation (MFC) imaging.
MATERIALS AND METHODS: With a 3T MR system, we studied 17
patients with relapsing-remitting MS and 14 age-matched
healthy control subjects. We acquired MFC imaging using an
asymmetric single-shot echo- planar imaging sequence. Regions
of interest were selected in both deep gray matter and white
matter regions, and the mean MFC values were compared between
patients and controls. We also correlated the MFC data with
lesion load and neuropsychologic tests in the patients.
RESULTS: MFC measured in the deep gray matter in patients with
MS was significantly higher than that in the healthy controls
(P .03), with an average increase of 24% in the globus
pallidus, 39.5% in the putamen, and 30.6% in the thalamus. The
increased iron deposition measured with MFC in the deep gray
matter in the patients correlated positively with the total
number of MS lesions (thalamus: r = 0.61, P
= .01; globus pallidus: r = 0.52, P = .02). A moderate but
= significant
correlation between the MFC value in the deep gray matter and
the neuropsychologic tests was also found.
CONCLUSION: Quantitative measurements of iron content with MFC
demonstrate increased accumulation of iron in the deep gray
matter in patients with MS, which may be associated with the
disrupted iron outflow pathway by lesions. Such abnormal
accumulation of iron may contribute to neuropsychologic
impairment and have implications for neurodegenerative
processes in MS.
http://www.ajnr.org/cgi/content/full/28/9/1639
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk