Ironjustic
Fri, Nov-02-07, 17:16
It may not be a good idea .. ? .. to touch ANY metal in a
hospital .. unless maybe it was painted .. ? .. real good with
good old fashioned starch based .. paint. Phytic acid in the
starch . The same paint they use for lead contaminated houses.
Mol Microbiol. 2007 Oct;66(2):468-83. Epub 2007 Sep 14. Links
The role of iron in Mycobacterium smegmatis biofilm formation:
the exochelin siderophore is essential in limiting iron
conditions for biofilm formation but not for planktonic
growth. Ojha A, Hatfull GF. Department of Biological Sciences,
University of Pittsburgh, Pittsburgh, PA 15260, USA.
Many species of mycobacteria form structured biofilm
communities at liquid-air interfaces and on solid surfaces.
Full development of Mycobacterium smegmatis biofilms requires
addition of supplemental iron above 1 microM ferrous sulphate,
although addition of iron is not needed for planktonic growth.
Microarray analysis of the M. smegmatis transcriptome shows
that iron-responsive genes - especially those involved in
siderophore synthesis and iron uptake - are strongly induced
during biofilm formation reflecting a response to iron
deprivation, even when 2 microM iron is present. The
acquisition of iron under these conditions is specifically
dependent on the exochelin synthesis and uptake pathways, and
the strong defect of an iron- exochelin uptake mutant suggests
a regulatory role of iron in the transition to biofilm growth.
In contrast, although the expression of mycobactin and iron
ABC transport operons is highly upregulated during biofilm
formation, mutants in these systems form normal biofilms in
low-iron (2 microM) conditions. A close correlation between
iron availability and matrix-associated fatty acids implies a
possible metabolic role in the late stages of biofilm
maturation, in addition to the early regulatory role. M.
smegmatis surface motility is similarly dependent on iron
availability, requiring both supplemental iron and the
exochelin pathway to acquire it.
PMID: 17854402 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
hospital .. unless maybe it was painted .. ? .. real good with
good old fashioned starch based .. paint. Phytic acid in the
starch . The same paint they use for lead contaminated houses.
Mol Microbiol. 2007 Oct;66(2):468-83. Epub 2007 Sep 14. Links
The role of iron in Mycobacterium smegmatis biofilm formation:
the exochelin siderophore is essential in limiting iron
conditions for biofilm formation but not for planktonic
growth. Ojha A, Hatfull GF. Department of Biological Sciences,
University of Pittsburgh, Pittsburgh, PA 15260, USA.
Many species of mycobacteria form structured biofilm
communities at liquid-air interfaces and on solid surfaces.
Full development of Mycobacterium smegmatis biofilms requires
addition of supplemental iron above 1 microM ferrous sulphate,
although addition of iron is not needed for planktonic growth.
Microarray analysis of the M. smegmatis transcriptome shows
that iron-responsive genes - especially those involved in
siderophore synthesis and iron uptake - are strongly induced
during biofilm formation reflecting a response to iron
deprivation, even when 2 microM iron is present. The
acquisition of iron under these conditions is specifically
dependent on the exochelin synthesis and uptake pathways, and
the strong defect of an iron- exochelin uptake mutant suggests
a regulatory role of iron in the transition to biofilm growth.
In contrast, although the expression of mycobactin and iron
ABC transport operons is highly upregulated during biofilm
formation, mutants in these systems form normal biofilms in
low-iron (2 microM) conditions. A close correlation between
iron availability and matrix-associated fatty acids implies a
possible metabolic role in the late stages of biofilm
maturation, in addition to the early regulatory role. M.
smegmatis surface motility is similarly dependent on iron
availability, requiring both supplemental iron and the
exochelin pathway to acquire it.
PMID: 17854402 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk