Ironjustic
Fri, Nov-02-07, 17:16
If the free iron wasn't there .. would it still compete .. ?
Sorta like if a man says something in the woods .. is he still
wrong .. ?
Voltage-gated Calcium Channels Provide an Alternate Route for
Iron Uptake in Neuronal Cell Cultures.
JA Gaasch, WJ Geldenhuys, PR Lockman, DD Allen, CJ Van der
Schyf Department of Pharmaceutical Sciences, Texas Tech
University Health Sciences Center, School of Pharmacy,
Amarillo, Texas, 79106, USA. Social Bookmarking
Recent studies suggest that iron enters cardiomyocytes via the
L-type voltage-gated calcium channel (VGCC). The neuronal VGCC
may also provide iron entry. As with calcium, extraneous iron
is associated with the pathology and progression of
neurodegenerative diseases such as Parkinson's and Alzheimer's
disease. VGCCs, ubiquitously expressed, may be an important
route of excessive entry for both iron and calcium,
contributing to cell toxicity or death. We evaluated the
uptake of (45)Ca(2+) and (55)Fe(2+) into NGF-treated rat PC12,
and murine N-2alpha cells. Iron not only competed with calcium
for entry into these cells, but iron uptake (similar to
calcium uptake) was inhibited by nimodipine, a specific L-type
VGCC blocker, and enhanced by FPL 64176, an L-VGCC activator,
in a dose-dependent manner. Taken together, these data suggest
that voltage-gated calcium channels are an alternate route for
iron entry into neuronal cells under conditions that promote
cellular iron overload toxicity.
[Pubmed Record - new window]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Sorta like if a man says something in the woods .. is he still
wrong .. ?
Voltage-gated Calcium Channels Provide an Alternate Route for
Iron Uptake in Neuronal Cell Cultures.
JA Gaasch, WJ Geldenhuys, PR Lockman, DD Allen, CJ Van der
Schyf Department of Pharmaceutical Sciences, Texas Tech
University Health Sciences Center, School of Pharmacy,
Amarillo, Texas, 79106, USA. Social Bookmarking
Recent studies suggest that iron enters cardiomyocytes via the
L-type voltage-gated calcium channel (VGCC). The neuronal VGCC
may also provide iron entry. As with calcium, extraneous iron
is associated with the pathology and progression of
neurodegenerative diseases such as Parkinson's and Alzheimer's
disease. VGCCs, ubiquitously expressed, may be an important
route of excessive entry for both iron and calcium,
contributing to cell toxicity or death. We evaluated the
uptake of (45)Ca(2+) and (55)Fe(2+) into NGF-treated rat PC12,
and murine N-2alpha cells. Iron not only competed with calcium
for entry into these cells, but iron uptake (similar to
calcium uptake) was inhibited by nimodipine, a specific L-type
VGCC blocker, and enhanced by FPL 64176, an L-VGCC activator,
in a dose-dependent manner. Taken together, these data suggest
that voltage-gated calcium channels are an alternate route for
iron entry into neuronal cells under conditions that promote
cellular iron overload toxicity.
[Pubmed Record - new window]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk