Ironjustic
Thu, Nov-01-07, 17:16
Haemophilia. 2007 Nov ;13 Suppl 3 :10-3 17822515 Pathogenesis
of haemophilic synovitis: experimental studies on blood-
induced joint damage. [My paper] L A Valentino , N Hakobyan ,
N Rodriguez , W K Hoots Hemarthrosis is a common manifestation
of haemophilia, and joint arthropathy remains a frequent
complication. Even though the exact mechanisms related to
blood-induced joint disease have not yet been fully
elucidated, it is likely that iron deposition in the synovium
induces an inflammatory response that causes not only immune
system activation but also stimulates angiogenesis. This
process ultimately results in cartilage and bone destruction.
Investigating the processes that occur in the early stages of
blood-induced joint disease in humans has been very limited.
Therefore, the use of haemophilic animal models is critical to
augment the understanding of this phenomenon. This article
discusses three cellular regulators (p53, p21 and TRAIL)
induced in synovial tissue that are important for iron
metabolism. A cartilage remodelling programme induced by the
release of cytokines and growth factors that result in
articular damage is also discussed. Full elucidation of the
pathogenesis of haemophilic joint disease is required to
identify new avenues for prevention and therapy.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
of haemophilic synovitis: experimental studies on blood-
induced joint damage. [My paper] L A Valentino , N Hakobyan ,
N Rodriguez , W K Hoots Hemarthrosis is a common manifestation
of haemophilia, and joint arthropathy remains a frequent
complication. Even though the exact mechanisms related to
blood-induced joint disease have not yet been fully
elucidated, it is likely that iron deposition in the synovium
induces an inflammatory response that causes not only immune
system activation but also stimulates angiogenesis. This
process ultimately results in cartilage and bone destruction.
Investigating the processes that occur in the early stages of
blood-induced joint disease in humans has been very limited.
Therefore, the use of haemophilic animal models is critical to
augment the understanding of this phenomenon. This article
discusses three cellular regulators (p53, p21 and TRAIL)
induced in synovial tissue that are important for iron
metabolism. A cartilage remodelling programme induced by the
release of cytokines and growth factors that result in
articular damage is also discussed. Full elucidation of the
pathogenesis of haemophilic joint disease is required to
identify new avenues for prevention and therapy.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk