trigonomet
Thu, Nov-01-07, 06:16
Effects of Atorvastatin on vitamin D levels in patients with
acute ischemic heart disease.
Am J Cardiol. 2007 Apr 1;99(7):903-5
Authors: P=E9rez-Castrill=F3n JL, Vega G, Abad L, Sanz A,
Chaves J, Hernandez G, Due=F1as A
Vitamin D deficiency is a risk factor for osteoporosis and
other chronic diseases, including type 1 diabetes,
hypertension, metabolic syndrome, and ischemic heart disease.
Cholesterol and vitamin D share the 7-dehydrocholesterol
metabolic pathway. This study evaluated the possible effect of
atorvastatin on vitamin D levels in patients with acute
ischemic heart disease. Eighty-three patients (52 men and 31
women) with an acute coronary syndrome (75 with acute
myocardial infarction and 8 with unstable angina) were
included. After diagnosis, patients received atorvastatin as
secondary prevention. Serum vitamin D was measured by
high-performance liquid chromatography at baseline and at 12
months. Atorvastatin treatment produced a statistically
significant decrease in cholesterol and triglyceride levels
and an increase in vitamin D levels (41+/-19 vs 47+/-19
nmol/L, p=3D0.003). Vitamin D deficiency was decreased by 75%
to 57% at 12 months.
In conclusion, atorvastatin increases vitamin D levels. This
increase could explain some of the beneficial effects of
atorvastatin at the cardiovascular level that are unrelated to
cholesterol levels.
PMID: 17398180
acute ischemic heart disease.
Am J Cardiol. 2007 Apr 1;99(7):903-5
Authors: P=E9rez-Castrill=F3n JL, Vega G, Abad L, Sanz A,
Chaves J, Hernandez G, Due=F1as A
Vitamin D deficiency is a risk factor for osteoporosis and
other chronic diseases, including type 1 diabetes,
hypertension, metabolic syndrome, and ischemic heart disease.
Cholesterol and vitamin D share the 7-dehydrocholesterol
metabolic pathway. This study evaluated the possible effect of
atorvastatin on vitamin D levels in patients with acute
ischemic heart disease. Eighty-three patients (52 men and 31
women) with an acute coronary syndrome (75 with acute
myocardial infarction and 8 with unstable angina) were
included. After diagnosis, patients received atorvastatin as
secondary prevention. Serum vitamin D was measured by
high-performance liquid chromatography at baseline and at 12
months. Atorvastatin treatment produced a statistically
significant decrease in cholesterol and triglyceride levels
and an increase in vitamin D levels (41+/-19 vs 47+/-19
nmol/L, p=3D0.003). Vitamin D deficiency was decreased by 75%
to 57% at 12 months.
In conclusion, atorvastatin increases vitamin D levels. This
increase could explain some of the beneficial effects of
atorvastatin at the cardiovascular level that are unrelated to
cholesterol levels.
PMID: 17398180