Ironjustic
Sat, Sep-29-07, 17:16
Exp Parasitol. 2007 Mar 24; : 17521632 Trypanosoma cruzi:
Treatment with the iron chelator desferrioxamine reduces
parasitemia and mortality in experimentally infected mice. [My
paper] Jerusa Marilda Arantes , Maria L=FAcia Pedrosa , Helen
Rodrigues Martins , Vanja Maria Veloso , Marta de Lana , Maria
Terezinha Bahia , Washington Luiz Tafuri , Cl=E1udia Martins
Carneiro The effects of prolonged treatment with iron chelator
(desferrioxamine) on the development of infection in mice
inoculated with Y Trypanosoma cruzi were determined.
Infected/treated mice presented lower levels of parasitemia
and reduced mortality rate compared with infected/non-treated
animals. The five out of twenty infected/treated mice that
survived the acute phase of infection showed negative
hemoculture and positive ELISA in the acute and chronic phases
and positive PCR in the acute phase: in the chronic phase,
three of the animals presented negative PCR. The single
surviving infected/non-treated animal exhibited positive
hemoculture, PCR and ELISA in both phases of infection.
Infected groups presented lower levels of iron in the liver
compared with treated/non-infected or non-treated/non-infected
animals. The serum iron levels of the infected/non-treated
group were higher on the 21st day post-infection in comparison
with control and infected/treated groups. These results
suggest that decrease of iron in the host leads to T. cruzi
infection attenuation.
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Chagas Disease is is caused by the protozoan parasite
Trypanosoma cruzi. It is transmitted to man when the
trypanosomes, present in the feces of nocturnal bloodsucking
reduviid bugs, come into contact with wounds and scratches on
the skin or the delicate internal tissues of the nose and
mouth. The presence of the parasite in the heart muscles and
central nervous system results in serious inflammation and
lesions, which can prove fatal. The disease, limited to poor
rural areas in South and Central America, is especially
prevalent in children and young adults. It may be treated with
nifurtimox. See also trypanosomiasis. Bantam Medical
Dictionary.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Treatment with the iron chelator desferrioxamine reduces
parasitemia and mortality in experimentally infected mice. [My
paper] Jerusa Marilda Arantes , Maria L=FAcia Pedrosa , Helen
Rodrigues Martins , Vanja Maria Veloso , Marta de Lana , Maria
Terezinha Bahia , Washington Luiz Tafuri , Cl=E1udia Martins
Carneiro The effects of prolonged treatment with iron chelator
(desferrioxamine) on the development of infection in mice
inoculated with Y Trypanosoma cruzi were determined.
Infected/treated mice presented lower levels of parasitemia
and reduced mortality rate compared with infected/non-treated
animals. The five out of twenty infected/treated mice that
survived the acute phase of infection showed negative
hemoculture and positive ELISA in the acute and chronic phases
and positive PCR in the acute phase: in the chronic phase,
three of the animals presented negative PCR. The single
surviving infected/non-treated animal exhibited positive
hemoculture, PCR and ELISA in both phases of infection.
Infected groups presented lower levels of iron in the liver
compared with treated/non-infected or non-treated/non-infected
animals. The serum iron levels of the infected/non-treated
group were higher on the 21st day post-infection in comparison
with control and infected/treated groups. These results
suggest that decrease of iron in the host leads to T. cruzi
infection attenuation.
---------------------------------------------------
Chagas Disease is is caused by the protozoan parasite
Trypanosoma cruzi. It is transmitted to man when the
trypanosomes, present in the feces of nocturnal bloodsucking
reduviid bugs, come into contact with wounds and scratches on
the skin or the delicate internal tissues of the nose and
mouth. The presence of the parasite in the heart muscles and
central nervous system results in serious inflammation and
lesions, which can prove fatal. The disease, limited to poor
rural areas in South and Central America, is especially
prevalent in children and young adults. It may be treated with
nifurtimox. See also trypanosomiasis. Bantam Medical
Dictionary.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk