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Ironjustic
Fri, Sep-28-07, 06:16
<<snip>> increased oxidant and decreased antioxidant
capacity <<snip>>

Rheumatol Int. 2007 Oct;27(12):1131-4. Epub 2007 Apr 19. Links
Serum oxidative-antioxidative status in patients with
ankylosing spondilitis. Karakoc M, Altindag O, Keles H, Soran
N, Selek S. Department of Physical Medicine and
Rehabilitation, Ozel Yasam Hospital, Aksaray, Turkey.

Ankylosing spondylitis (AS) is an inflammatory disorder with
unknown etiology that mainly affects the axial skeleton as
well as the peripheral joints and extra-articular structures.
The aim of this study was to evaluate the total antioxidant
status (TAS), total oxidative status (TOS) and oxidative
stress index (OSI) in patients with ankylosing spondylitis
(AS). Fifty AS patients with a mean Bath AS Activity Index
(BASDAI) 4.6 (range 4-9.3) and 26 healthy controls were
included in the study. Plasma TAS, TOS levels were determined
by using novel automated methods. The OSI was calculated.
Plasma TOS level and OSI values were significantly higher, and
plasma TAS level was lower in patients than in healthy
controls (15.8 +/- 4. 9 vs. 4.3 +/- 2.8, 12.8 +/- 3. 9 vs. 9.6
+/- 5.5, 1.2 +/- 0.03 vs. 1.8 +/- 0.2, respectively, P < 0.001
for all). There was no significant correlation between
oxidant/antioxidant parameters and disease activity. The
results of this study indicated that increased oxidant and
decreased antioxidant capacity may be associated with the
pathogenesis of AS.

PMID: 17443328 [PubMed - in process]

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