Crucial Role of Iron Accumulation

[Ironjustic]

Med Hypotheses 2001 Nov;57(5):539-43

The possible crucial role of iron accumulation combined with
low tryptophan, zinc and manganese in carcinogenesis.
Johnson S.

Iron can react with citric acid, interfering with the Krebs
cycle, hence with oxidative phosphorylation. Free iron (Fe)
can cause considerable oxidative damage both through Fenton
reactions and by activating xanthine oxidase, which produces
both superoxide (O(2-)) and uric acid (abundant in many
cancers). It can also react with lactic acid, reducing its
elimination and increasing the acidity of the cytoplasm. Fe
can also wreak havoc by reacting with tryptophan, the least
abundant and most delicate essential amino acid, which is
necessary for the production of serotonin and other
substances required by the immune system to fight cancer. On
the other hand, in the presence of iron, the tryptophan
metabolite quinolinate causes intense lipid peroxidation.
Similarly, several other carcinogenic metabolites of
tryptophan are particularly dangerous in the presence of Fe.
Excess Fe may also interfere with manganese superoxide
dismutase and impair the initiation of apoptosis by the
mitochondrion, rendering the cells impervious to all the
signals to undergo apoptosis from without and from within the
cell. Moreover, Fe may also play a crucial role on telomere
repair, by activating telomerase. Therefore, by inhibiting
apoptosis and enhancing chromosome repair, Fe may bestow
immortality upon the cancer cell. Furthermore, Fe is one of
the triggers for mitosis. Therefore, increased Fe levels may
be essential for the rapid growth characteristic of many
malignancies. In turn, the rapid growth further depletes
resources from the healthy tissues, exacerbating the
deficiencies of the other elements and reducing the ability
to fight the malignancy. Copyright 2001 Harcourt Publishers
Ltd. PMID: 11735307 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------
--------------= =AD=AD=AD-----

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[ferrous]

"Free iron (Fe) can cause considerable oxidative damage"

What are the two major ways the body regulates free iron?

Jesus ate a mediterranean diet.

[Ironjustic]

>> On Sep 27, 7:37 am, ferr...@paris.com wrote:
"Free iron (Fe) can cause considerable oxidative damage"

What are the two major ways the body regulates free iron? <<

You mean .. labile iron pool .. ? .. is that what you mean ..

Let's see ..

Let's type that in .. and see .. ?

That would be the easy thing to do ..

Short pause here to make it appear as if I really looked
this up ...
--
--

Sooo .. free iron / labile iron pool .. is "unregulated iron"
..

I guess if it is .. unregulated .. means the body does NOT
.. regulate
it .. ?

Yep ..

--------------------------------------------------------------
--------------= =AD=AD=AD=AD-----

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[ferrous]

>> Free iron (Fe) can cause considerable oxidative damage"

> What are the two major ways the body regulates free iron?

How about this?

[_] 1: World J Gastroenterol. 2007 Sep 21;13(35):4737-45.
Liver-gut axis in the regulation of iron homeostasis.

The human body requires about 1-2 mg of iron per day
for its normal functioning, and dietary iron is the
only source for this essential metal. Since humans
do not possess a mechanism for the active excretion
of iron, the amount of iron in the body is
determined by the amount absorbed across the
proximal small intestine and, consequently,
intestinal iron absorption is a highly regulated
process. In recent years, the liver has emerged as a
central regulator of both iron absorption and iron
release from other tissues. It achieves this by
secreting a peptide hormone called hepcidin that
acts on the small intestinal epithelium and other
cells to limit iron delivery to the plasma. Hepcidin
itself is regulated in response to various systemic
stimuli including variations in body iron stores,
the rate of erythropoiesis, inflammation and
hypoxia, the same stimuli that have been known for
many years to modulate iron absorption. This review
will summarize recent findings on the role played by
the liver and hepcidin in the regulation of body
iron absorption.

PMID: 17729395 [PubMed - in process]