Ironjustic
Wed, Sep-26-07, 17:16
American Journal of Clinical Nutrition, Vol. 85, No. 3,
702-708, March 2007 =A9 2007 American Society for Nutrition
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ORIGINAL RESEARCH COMMUNICATION
Choline-related supplements improve abnormal plasma
methionine- homocysteine metabolites and glutathione status in
children with cystic fibrosis1,2,3 Sheila M Innis, A George F
Davidson, Stepan Melynk and S Jill James 1 From the Department
of Paediatrics, University of British Columbia, Vancouver, BC,
Canada (SMI and AGFD), and the Department of Pediatrics,
University of Arkansas for Medical Sciences, Little Rock, AR
(SM and SJJ)
Background: Liver triacylglycerol accumulation and oxidative
stress are common in cystic fibrosis (CF) and also occur in
choline deficiency. Previously, we showed an association
between elevated plasma homocysteine, reduced ratios of
S-adenosylmethionine to S- adenosylhomocysteine (SAM:SAH) and
of phosphatidylcholine to phosphatidylethanolamine, and
phospholipid malabsorption in children with CF.
Objective: The objective was to address a possible relation
between altered methionine-homocysteine metabolism and choline
metabolism in children with CF.
Design: Children with CF were assigned without bias to
supplementation with 2 g lecithin/d (n =3D 13), 2 g choline/d
(n =3D 12), or 3 g betaine/d (n =3D 10) for 14 d. Plasma
concentrations of methionine, adenosine, cysteine,
cysteinyl-glycine, glutathione, glutathione disulfide (GSSG),
and fatty acids; SAM:SAH; and red blood cell phospholipids
were measured within each group of children with CF before and
after supplementation. Plasma from healthy children without CF
(n =3D 15) was analyzed to obtain reference data.
Results: Children with CF had higher plasma homocysteine, SAH,
and adenosine and lower methionine, SAM:SAH, and
glutathione:GSSG than did children without CF. Supplementation
with lecithin, choline, or betaine resulted in a significant
increase in plasma methionine, SAM, SAM:SAH, and
glutathione:GSSG and a decrease in SAH (n =3D 35).
Supplementation with choline or betaine was associated with a
significant decrease in plasma SAH and an increase in SAM:SAH,
methionine, and glutathione:GSSG. Supplementation with
lecithin or choline also increased plasma methionine and SAM.
Conclusion: We showed that dietary supplementation with
choline- related compounds improves the low SAM:SAH and
glutathione redox balance in children with CF.
Key Words: Choline =B7 betaine =B7 phospholipids =B7 ratio
of glutathione to glutathione disulfide =B7 GSH:GSSG =B7
cystic fibrosis
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Lancet. 1977 Jul 9;2(8028):68-9. Related Articles, Links
Lecithin consumption raises serum-free-choline levels.
Wurtman RJ, Hirsch MJ, Growdon JH.
Consumption of choline by rats sequentially increases
serum-choline, brain-choline, and brain-acetylcholine
concentrations. In man consumption of choline increases in
levels in the serum and cerebrospinal fluid; its
administration is an effective way of treating
tardive dyskinesia. We found that oral lecithin is
considerably more effective in raising human serum-choline
levels than an equivalent quantity of choline chloride. 30
minutes after ingestion of choline chloride (2-3 g free base),
serum-choline levels rose by 86% and returned to normal values
within 4 hours; 1 hour after lecithin ingestion, these levels
rose by 265% and remained significantly raised for 12 hours.
Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis by increasing the
availability of choline, its precursor in the blood.
PMID: 69151 [PubMed - indexed for MEDLINE]
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Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
702-708, March 2007 =A9 2007 American Society for Nutrition
--------------------------------------------------------------
--------------=
-----
ORIGINAL RESEARCH COMMUNICATION
Choline-related supplements improve abnormal plasma
methionine- homocysteine metabolites and glutathione status in
children with cystic fibrosis1,2,3 Sheila M Innis, A George F
Davidson, Stepan Melynk and S Jill James 1 From the Department
of Paediatrics, University of British Columbia, Vancouver, BC,
Canada (SMI and AGFD), and the Department of Pediatrics,
University of Arkansas for Medical Sciences, Little Rock, AR
(SM and SJJ)
Background: Liver triacylglycerol accumulation and oxidative
stress are common in cystic fibrosis (CF) and also occur in
choline deficiency. Previously, we showed an association
between elevated plasma homocysteine, reduced ratios of
S-adenosylmethionine to S- adenosylhomocysteine (SAM:SAH) and
of phosphatidylcholine to phosphatidylethanolamine, and
phospholipid malabsorption in children with CF.
Objective: The objective was to address a possible relation
between altered methionine-homocysteine metabolism and choline
metabolism in children with CF.
Design: Children with CF were assigned without bias to
supplementation with 2 g lecithin/d (n =3D 13), 2 g choline/d
(n =3D 12), or 3 g betaine/d (n =3D 10) for 14 d. Plasma
concentrations of methionine, adenosine, cysteine,
cysteinyl-glycine, glutathione, glutathione disulfide (GSSG),
and fatty acids; SAM:SAH; and red blood cell phospholipids
were measured within each group of children with CF before and
after supplementation. Plasma from healthy children without CF
(n =3D 15) was analyzed to obtain reference data.
Results: Children with CF had higher plasma homocysteine, SAH,
and adenosine and lower methionine, SAM:SAH, and
glutathione:GSSG than did children without CF. Supplementation
with lecithin, choline, or betaine resulted in a significant
increase in plasma methionine, SAM, SAM:SAH, and
glutathione:GSSG and a decrease in SAH (n =3D 35).
Supplementation with choline or betaine was associated with a
significant decrease in plasma SAH and an increase in SAM:SAH,
methionine, and glutathione:GSSG. Supplementation with
lecithin or choline also increased plasma methionine and SAM.
Conclusion: We showed that dietary supplementation with
choline- related compounds improves the low SAM:SAH and
glutathione redox balance in children with CF.
Key Words: Choline =B7 betaine =B7 phospholipids =B7 ratio
of glutathione to glutathione disulfide =B7 GSH:GSSG =B7
cystic fibrosis
--------------------------------------------------------------
--------------= =AD=AD-----
Lancet. 1977 Jul 9;2(8028):68-9. Related Articles, Links
Lecithin consumption raises serum-free-choline levels.
Wurtman RJ, Hirsch MJ, Growdon JH.
Consumption of choline by rats sequentially increases
serum-choline, brain-choline, and brain-acetylcholine
concentrations. In man consumption of choline increases in
levels in the serum and cerebrospinal fluid; its
administration is an effective way of treating
tardive dyskinesia. We found that oral lecithin is
considerably more effective in raising human serum-choline
levels than an equivalent quantity of choline chloride. 30
minutes after ingestion of choline chloride (2-3 g free base),
serum-choline levels rose by 86% and returned to normal values
within 4 hours; 1 hour after lecithin ingestion, these levels
rose by 265% and remained significantly raised for 12 hours.
Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis by increasing the
availability of choline, its precursor in the blood.
PMID: 69151 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
--------------= =AD=AD-----
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk