Ironjustic
Mon, Sep-24-07, 06:15
<<snip>> The iron and the hemosiderin deposits induce
metabolic perturbations and tissue reorganization (gliosis and
sclerosis) around the cavernoma. These cortical modifications
seem to be responsible for the epileptic discharges but this
is difficult to demonstrate. <<snip>>
Neurochirurgie. 2007 Jun;53(2-3 Pt 2):156-62. Links
[Epileptogenicity and evaluation of epileptic risk][Article
in French]
Maugui=E8re F. Service de neurologie fonctionnelle et
d'=E9pileptologie, h=F4pital neurologique, groupement
hospitalier Est, hospices civils de Lyon (HCL), 59 boulevard
Pinel 69394, Lyon cedex 03, France. mauguier@univ- lyon1.fr
Epilepsy is the more frequent clinical manifestation of
hemispheric cavernomas in 50 to 75% of symptomatic cases; the
annual risk of a first seizure is evaluated from 1.5 to 2.5%.
As for all epileptogenic lesions, many questions arise: Is
the pathologic tissue or the perilesional cortex responsible
for the epileptic symptoms? Is the risk related with the
topography of the lesion? Is the prognosis of the epilepsy
related with the number of seizures? Can the epilepsy become
drug-resistant? Can surgical treatment cure the epilepsy?
When surgery is indicated, should lesionectomy alone or
lesionectomy plus perilesional tissue resection be performed?
The iron and the hemosiderin deposits induce metabolic
perturbations and tissue reorganization (gliosis and
sclerosis) around the cavernoma. These cortical modifications
seem to be responsible for the epileptic discharges but this
is difficult to demonstrate. Epileptic discharges have been
recorded in the perilesional tissue in only one study of the
literature. Drug therapy can usually control the seizures,
but it appears that surgery is more effective when the
epilepsy is recent and the seizures are not too frequent. For
these reasons it would appear licit to propose the resection
of the lesion when the surgical risk is not too great. In
case of drug-resistant epilepsy, the same function- targeted
surgical strategy may be used as for the management of any
severe epilepsy.
PMID: 17507046 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
metabolic perturbations and tissue reorganization (gliosis and
sclerosis) around the cavernoma. These cortical modifications
seem to be responsible for the epileptic discharges but this
is difficult to demonstrate. <<snip>>
Neurochirurgie. 2007 Jun;53(2-3 Pt 2):156-62. Links
[Epileptogenicity and evaluation of epileptic risk][Article
in French]
Maugui=E8re F. Service de neurologie fonctionnelle et
d'=E9pileptologie, h=F4pital neurologique, groupement
hospitalier Est, hospices civils de Lyon (HCL), 59 boulevard
Pinel 69394, Lyon cedex 03, France. mauguier@univ- lyon1.fr
Epilepsy is the more frequent clinical manifestation of
hemispheric cavernomas in 50 to 75% of symptomatic cases; the
annual risk of a first seizure is evaluated from 1.5 to 2.5%.
As for all epileptogenic lesions, many questions arise: Is
the pathologic tissue or the perilesional cortex responsible
for the epileptic symptoms? Is the risk related with the
topography of the lesion? Is the prognosis of the epilepsy
related with the number of seizures? Can the epilepsy become
drug-resistant? Can surgical treatment cure the epilepsy?
When surgery is indicated, should lesionectomy alone or
lesionectomy plus perilesional tissue resection be performed?
The iron and the hemosiderin deposits induce metabolic
perturbations and tissue reorganization (gliosis and
sclerosis) around the cavernoma. These cortical modifications
seem to be responsible for the epileptic discharges but this
is difficult to demonstrate. Epileptic discharges have been
recorded in the perilesional tissue in only one study of the
literature. Drug therapy can usually control the seizures,
but it appears that surgery is more effective when the
epilepsy is recent and the seizures are not too frequent. For
these reasons it would appear licit to propose the resection
of the lesion when the surgical risk is not too great. In
case of drug-resistant epilepsy, the same function- targeted
surgical strategy may be used as for the management of any
severe epilepsy.
PMID: 17507046 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk