Ironjustic
Mon, Sep-24-07, 06:15
<<snip>> newly appeared dot-like hemosiderin spots may be
associated with SVD recurrence <<snip>>
J Neuroimaging. 2007 Jul;17(3):204-10. Links Dynamics of
dot-like hemosiderin spots on T2*-weighted MRIs associated
with stroke recurrence. Imaizumi T, Honma T, Horita Y, Chiba
M, Kawamura M, Miyata K, Kohama I, Niwa J. Department of
Neurosurgery, Kushiro City General Hospital, Kushiro,
Hokkaido, Japan. timaizum@d9.dion.ne.jp
BACKGROUND AND PURPOSE: Dot-like low-intensity spots (dot-like
hemosiderin spots: dotHSs) on gradient echo T2*-weighted (-w)
brain magnetic resonance imaging (MRIs) are frequently
associated with cerebral small vessel disease (SVD), including
deep intracerebral hemorrhages and lacunar infarctions. This
study investigated how numbers of newly appeared dotHSs
contribute to recurrent SVD. METHODs: We prospectively
analyzed numbers of newly appeared dotHSs in 12 patients with
prior SVD (8 males, 4 females; mean 67.6 +/- 10.7 years old)
readmitted with recurring SVD between October 2001 and March
2003. Numbers of appeared dotHSs per year were counted on
T2*-w MRI scans after SVD recurrence and compared to previous
MRIs. Seventy-one outpatients (35 males, 36 females; mean 64.3
+/- 9.6 years old) with histories of intracerebral hemorrhages
(ICH) that came to the hospital during the study period served
as controls. The hazard ratio (HR) for recurrence was
estimated from a multivariate logistic regression model, using
the number of appeared dotHSs (per year) and other risk
factors. RESULTS: Multivariate analyses revealed that an
elevated rate of recurrence was found in patients with
substantial numbers of appeared dotHSs (>or=5/ year) (HR,
7.34; P= 0.0008). We also analyzed factors associated with the
numbers of appeared dotHSs. A number of appeared dotHSs
(>or=5/ year) was significantly and independently associated
with the initial number of dotHSs (>or=10) on T2*-w MRIs
following the first SVD (HR,
18.6; P= 0.0001). CONCLUSIONS: Though a small sample size
limited the power of our analyses, our findings suggest
that a number of newly appeared dotHSs may be associated
with SVD recurrence.
PMID: 17608905 [PubMed - indexed for MEDLINE]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
associated with SVD recurrence <<snip>>
J Neuroimaging. 2007 Jul;17(3):204-10. Links Dynamics of
dot-like hemosiderin spots on T2*-weighted MRIs associated
with stroke recurrence. Imaizumi T, Honma T, Horita Y, Chiba
M, Kawamura M, Miyata K, Kohama I, Niwa J. Department of
Neurosurgery, Kushiro City General Hospital, Kushiro,
Hokkaido, Japan. timaizum@d9.dion.ne.jp
BACKGROUND AND PURPOSE: Dot-like low-intensity spots (dot-like
hemosiderin spots: dotHSs) on gradient echo T2*-weighted (-w)
brain magnetic resonance imaging (MRIs) are frequently
associated with cerebral small vessel disease (SVD), including
deep intracerebral hemorrhages and lacunar infarctions. This
study investigated how numbers of newly appeared dotHSs
contribute to recurrent SVD. METHODs: We prospectively
analyzed numbers of newly appeared dotHSs in 12 patients with
prior SVD (8 males, 4 females; mean 67.6 +/- 10.7 years old)
readmitted with recurring SVD between October 2001 and March
2003. Numbers of appeared dotHSs per year were counted on
T2*-w MRI scans after SVD recurrence and compared to previous
MRIs. Seventy-one outpatients (35 males, 36 females; mean 64.3
+/- 9.6 years old) with histories of intracerebral hemorrhages
(ICH) that came to the hospital during the study period served
as controls. The hazard ratio (HR) for recurrence was
estimated from a multivariate logistic regression model, using
the number of appeared dotHSs (per year) and other risk
factors. RESULTS: Multivariate analyses revealed that an
elevated rate of recurrence was found in patients with
substantial numbers of appeared dotHSs (>or=5/ year) (HR,
7.34; P= 0.0008). We also analyzed factors associated with the
numbers of appeared dotHSs. A number of appeared dotHSs
(>or=5/ year) was significantly and independently associated
with the initial number of dotHSs (>or=10) on T2*-w MRIs
following the first SVD (HR,
18.6; P= 0.0001). CONCLUSIONS: Though a small sample size
limited the power of our analyses, our findings suggest
that a number of newly appeared dotHSs may be associated
with SVD recurrence.
PMID: 17608905 [PubMed - indexed for MEDLINE]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk