Ironjustic
Mon, Sep-24-07, 06:15
<<snip>> Progressive fatty replacement of the pancreas
parenchyma <<snip>>
J Formos Med Assoc. 2007 Aug;106(8):676-9. Links Rapidly
Progressive Pancreatic Lipomatosis in a Young Adult Patient
with Transfusion-dependent Myelodysplastic Syndrome. Lin WC,
Chen JH, Lin CH, Shen WC. Department of Radiology, China
Medical University Hospital, Taichung, Taiwan.
Pancreatic lipomatosis is defined as deposition of fat cells
in pancreatic parenchyma. Although the etiology of this
condition is still unclear, it is not uncommon in the elderly,
obese individuals, and a variety of transfusion-dependent
hematologic diseases such as beta-thalassemia major.
Pancreatic lipomatosis associated with transfusion-dependent
myelodysplastic syndrome (MDS) has never been reported. We
present a 17-year-old male patient with transfusion- dependent
MDS. He received transfusion of a total of 345 units of blood
in a period of 18 months but without iron chelating agent.
Progressive fatty replacement of the pancreas parenchyma was
found by a series of computed tomography images over seven
hospital admissions due to repeated infections. Bone marrow
biopsy revealed hemosiderin deposition. Because of his poor
response to induction chemotherapy, stem cell transplantation
was suggested, but the patient died of sepsis before the
therapeutic procedure could take place. Although most patients
with pancreatic lipomatosis have neither clinical symptoms nor
abnormal laboratory data, it may cause endocrine and exocrine
pancreas dysfunction. In this reported case, mild exocrine
dysfunction was noted on the last admission. Clinicians should
be cautious of hemosiderin deposition after large amount of
blood transfusion and chelating therapy should be given to
avoid iron overload.
PMID: 17711803 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
parenchyma <<snip>>
J Formos Med Assoc. 2007 Aug;106(8):676-9. Links Rapidly
Progressive Pancreatic Lipomatosis in a Young Adult Patient
with Transfusion-dependent Myelodysplastic Syndrome. Lin WC,
Chen JH, Lin CH, Shen WC. Department of Radiology, China
Medical University Hospital, Taichung, Taiwan.
Pancreatic lipomatosis is defined as deposition of fat cells
in pancreatic parenchyma. Although the etiology of this
condition is still unclear, it is not uncommon in the elderly,
obese individuals, and a variety of transfusion-dependent
hematologic diseases such as beta-thalassemia major.
Pancreatic lipomatosis associated with transfusion-dependent
myelodysplastic syndrome (MDS) has never been reported. We
present a 17-year-old male patient with transfusion- dependent
MDS. He received transfusion of a total of 345 units of blood
in a period of 18 months but without iron chelating agent.
Progressive fatty replacement of the pancreas parenchyma was
found by a series of computed tomography images over seven
hospital admissions due to repeated infections. Bone marrow
biopsy revealed hemosiderin deposition. Because of his poor
response to induction chemotherapy, stem cell transplantation
was suggested, but the patient died of sepsis before the
therapeutic procedure could take place. Although most patients
with pancreatic lipomatosis have neither clinical symptoms nor
abnormal laboratory data, it may cause endocrine and exocrine
pancreas dysfunction. In this reported case, mild exocrine
dysfunction was noted on the last admission. Clinicians should
be cautious of hemosiderin deposition after large amount of
blood transfusion and chelating therapy should be given to
avoid iron overload.
PMID: 17711803 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk