Ferritin and Heart Attack

[Ironjustic]

Ferritin, a potent threat for acute myocardial infarction?
Auteur(s) / Author(s) SILVIA Wilma Delphine ; BISWAS
Sharmistha ; UTHAPPA Sheila ; SHETTY P=2E ; R=E9sum=E9 /
Abstract Background : Studies conducted have yielded
contradicting results on the rote of ferritin as a risk factor
for acute myocardial infarction (AMI). The relation of
ferritin status to risk of AMI in Indian men, along with other
established major risk factors like serum total cholesterol,
HDL cholesterol, LDL cholesterol, VLDL cholesterol and
triglycerides has not been documented previously. The
hypothesis that increased serum ferritin was related to
increased chances of AMI along with the risk factors was
tested. Methods : Case control study involving 145 men (100
cases and 45 healthy control subjects) in the age group of
30-70 years. Serum ferritin levels were estimated by using
ELISA, and other risk factors by enzymatic methods. Results :
Increased serum ferritin levels significantly (p < 0.001)
correlated with an increase of other risk factors in Indian
male patients with AMI. Conclusion: Significant direct
correlation between serum ferritin levels and risk of AMI was
observed. Revue / Journal Title Journal of Association of
Physicians of India (J. Assoc. Phys. India) ISSN 0004-5772
Source / Source 2003, vol. 51, nooct, pp. 947-950 [4 page(s)
(article)] Langue / Language Anglais

Editeur / Publisher Association of Physicians of India,
Bombay, INDE (1953) (Revue)

Localisation / Location INIST-CNRS, Cote INIST : 19760,
35400011337350.0010

Copyright 2006 INIST-CNRS. All rights reserved

Toute reproduction ou diffusion m=EAme partielle, par quelque
proc=E9d=E9 ou sur tout support que ce soit, ne pourra =EAtre
faite sans l'accord pr=E9alable =E9crit de l'INIST-CNRS. No
part of these records may be reproduced of distributed, in any
form or by any means, without the prior written permission of
INIST-CNRS.

N=BA notice refdoc (ud4) : 15221268

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[Flec]

Killfiled your new email addy

[Medusa]

On Aug 14, 4:03 am, "Flec" <n...@emergencycare.com.au> wrote:
> Killfiled your new email addy

Yep. Looks like he's kicked off another ISP.

Medusa

[Ironjustic]

>> On Aug 14, 1:39 pm, Medusa <Medusa4...@yahoo.com> wrote:
On Aug 14, 4:03 am, "Flec" <n...@emergencycare.com.au> wrote:

Killfiled your new email addy Yep. Looks like he's kicked off
another ISP. Medusa <<

" Iron excess can result in Cardiomyopathy. "

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Jeez it looks like you are at good at computers as you are in
Science or religion .. eh .. doofus ..

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

You have a bad heart .. too .. ?

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Jeez .. you're in rough .. shape ..

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Unless you don't have heart problems .. ?

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Then what are you doing on this thread .. ?

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Disruption .. ?

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Contribution .. ?

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

I believe it is attempted .. disruption ..

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

YOUR .. 'claim to fame' ..

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Heh .. heh ..

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Now .. hit the .. road ..

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Jrkff ..

<<snip>> Serum ferritin levels in acute myocardial infarction
(AMI). <<snip>>

Contributing SRB Member David Meyers, MD, University of Kansas
Medical Center

Arrhythmia with shortness of breath and chronic fatigue might
be a sign of cardiomyopathy. Cardiomyopathy is a disease of
the heart muscle where the muscles may be stretched (dilated)
enlarged (hypertrophic) or cannot pump properly (restrictive)

Restrictive cardiomyopathy is sometimes found in those who
have hemochromatosis (HHC). Hemochromatosis is an inherited
disorder of iron metabolism where excess iron collects in the
functional part of an organ (parenchymal tissues) in ferritin
or hemosiderin. In the heart, restrictive cardiomyopathy can
be a result of iron in excess.

Transferrin - a protein - binds to iron we absorb and moves it
to storage in ferritin or to bone marrow cells where
hemoglobin can be made. When transferrin is highly saturated
and can no longer bind to iron excess iron may get free and
become a dangerous oxidant or begin to precipitate as
hemosiderin.

Ferritin contains mobilized iron, the type that can be removed
with phlebotomy treatment or blood donation. Hemosiderin is
not mobilizable; it cannot be moved out of the cells. Instead,
it accumulates in tissues damaging the targeted organ,
impairing it's ability to function.

Early diagnosis of hemochromatosis by a physician can diminish
development of restrictive cardiomyopathy. Two simple blood
tests done fasting - nothing by mouth after midnight or prior
to blood work: ferritin and transferrin iron saturation
percentage will provide a physician with a patient's iron
loading status. Ferritin tells the physician approximately how
much iron has accumulated in various organs. The heart is
especially vulnerable because it produces less ferritin than
other organs like the liver, spleen and bone marrow.
Therefore, membranes of the heart are prime targets for iron
to accumulate, impede function of cardiac muscles to pump
blood efficiently and possibly lead to heart attack.

Transferrin iron saturation percentage reveals just how
saturated transferrin is with iron. When the percentage is
high, transferrin is not going to be able to efficiently bind
to iron. Therefore any excess iron that a patient absorbs that
cannot be bound to transferrin will become free, which can
nourish cancer cells, or load in the heart and other organs as
hemosiderin.

Family history of heart attack or hemochromatosis are risk
factors sufficient to prompt a physician to check body iron
status. If ferritin is above 300ng/mL in males and 200ng/mL in
females with a transferrin saturation percentage above 45%,
trial phlebotomy is suggested as treatment. Trial phlebotomy
involves removing one unit of blood per week for a period of
time, usually about four weeks, while observing hemoglobin. In
an iron overloaded patient, Hemoglobin will rebound after
blood extraction.

Under these circumstances, phlebotomy treatment may continue
until ferritin is within a safe range of 25-75 ng/mL.

Afterward, a patient will follow a maintenance program as
recommended by the attending physician. Maintenance may
involve as few as 2 to 3 blood donations per year and simple
changes to diet and exercise. Cardiac diagnostic aids such as
electrocardiogram (EKG) or Magnetic Resonance Imagining (MRI)
will not reveal iron in the heart. A highly skilled
cardiologist using an echocardiogram can observe iron or in
rare occasions with heart biopsy and stain.

--------------------------------------------------------------
--------------

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk