Ironjustic
Mon, Aug-13-07, 17:16
<<snip>> increased body iron stores of obese women with
polycystic ovary syndrome <<snip>>
Diabetes Care DOI: 10.2337/dc07-0642
Original Research
The increased body iron stores of obese women with polycystic
ovary syndrome are a consequence of insulin resistance and
hyperinsulinism, and do not result from reduced menstrual
losses. Manuel Luque-Ram=EDrez, M.D., Francisco
=C1lvarez-Blasco, M.D., Jos=E9 I. Botella-Carretero, M.D.,
Ph.D., Raul Sanch=F3n, M.D., Jos=E9 L. San Mill=E1n, Ph.D. and
H=E9ctor F. Escobar-Morreale, M.D., Ph.D. Endocrinology and
Molecular Genetics, Hospital Universitario Ram=F3n y Cajal &
Universidad de Alcal=E1, Madrid, Spain
hescobarm.hrc@salud.madrid.org
ABSTRACT
Objective:Increased serum ferritin levels, indicating
increased body iron stores, have been found in overweight and
obese PCOS women. This finding might result from the reduced
menstrual losses secondary to from oligo- or amenorrhea, or
from the hyperinsulinism secondary to insulin resistance
because insulin favors the intestinal absorption and the
tissue deposition of iron. To explore which of these
mechanisms is responsible for the increase in body iron stores
in PCOS women, we have monitored the changes in serum ferritin
levels during treatment with an antiandrogenic oral
contraceptive or with an insulin sensitizer.
Research Design and Methods:Thirty-four consecutive PCOS
patients were randomized to an oral contraceptive containing
35 =B5g of ethinyl- estradiol plus 2 mg of cyproterone acetate
(Diane35 Diario) or metformin (850 mg twice daily), and their
serum ferritin levels were evaluated at baseline and after 12
and 24 weeks of treatment.
Results:Despite the fact that treatment with Diane35 Diario
restored regular menstrual cycles in all the patients, whereas
metformin only did so in 50% of them, serum ferritin levels
decreased at 12 and 24 weeks of treatment only with metformin,
in association with a marked increase in insulin sensitivity.
On the contrary, no changes in ferritin and insulin
sensitivity were observed with Diane35 Diario.
Conclusions:Our present results suggest that insulin
resistance and hyperinsulinism, and not the reduced menstrual
losses secondary to from oligo- or amenorrhea, are responsible
of the increased ferritin levels and body iron stores found in
overweight and obese PCOS women.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
polycystic ovary syndrome <<snip>>
Diabetes Care DOI: 10.2337/dc07-0642
Original Research
The increased body iron stores of obese women with polycystic
ovary syndrome are a consequence of insulin resistance and
hyperinsulinism, and do not result from reduced menstrual
losses. Manuel Luque-Ram=EDrez, M.D., Francisco
=C1lvarez-Blasco, M.D., Jos=E9 I. Botella-Carretero, M.D.,
Ph.D., Raul Sanch=F3n, M.D., Jos=E9 L. San Mill=E1n, Ph.D. and
H=E9ctor F. Escobar-Morreale, M.D., Ph.D. Endocrinology and
Molecular Genetics, Hospital Universitario Ram=F3n y Cajal &
Universidad de Alcal=E1, Madrid, Spain
hescobarm.hrc@salud.madrid.org
ABSTRACT
Objective:Increased serum ferritin levels, indicating
increased body iron stores, have been found in overweight and
obese PCOS women. This finding might result from the reduced
menstrual losses secondary to from oligo- or amenorrhea, or
from the hyperinsulinism secondary to insulin resistance
because insulin favors the intestinal absorption and the
tissue deposition of iron. To explore which of these
mechanisms is responsible for the increase in body iron stores
in PCOS women, we have monitored the changes in serum ferritin
levels during treatment with an antiandrogenic oral
contraceptive or with an insulin sensitizer.
Research Design and Methods:Thirty-four consecutive PCOS
patients were randomized to an oral contraceptive containing
35 =B5g of ethinyl- estradiol plus 2 mg of cyproterone acetate
(Diane35 Diario) or metformin (850 mg twice daily), and their
serum ferritin levels were evaluated at baseline and after 12
and 24 weeks of treatment.
Results:Despite the fact that treatment with Diane35 Diario
restored regular menstrual cycles in all the patients, whereas
metformin only did so in 50% of them, serum ferritin levels
decreased at 12 and 24 weeks of treatment only with metformin,
in association with a marked increase in insulin sensitivity.
On the contrary, no changes in ferritin and insulin
sensitivity were observed with Diane35 Diario.
Conclusions:Our present results suggest that insulin
resistance and hyperinsulinism, and not the reduced menstrual
losses secondary to from oligo- or amenorrhea, are responsible
of the increased ferritin levels and body iron stores found in
overweight and obese PCOS women.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk