Ironjustic
Mon, Aug-13-07, 17:16
NOW .. simply .. counting the db's .
<<snip>> associated with a 3.5-fold increase in the risk of
death by 12 months <<snip>>
(The FASEB Journal. 2007;21:673.3) =A9 2007 FASEB ---------
-----------------------------------------------------------
---------=
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Serum Ferritin is Associated with HIV Disease Severity &
Mortality among Postpartum Zimbabwean Women Rahul Rawat1, Jean
Humphrey2,3, John Hargrove2, Robert Ntozini2, Kuda Mutasa2,
Peter Iliff2 and Rebecca Stoltzfus1 1 Division of Nutritional
Sciences, Cornell University, Savage Hall, Ithaca, NY, 14853,
2 ZVITAMBO Study Team, 1 Borrowdale Road, Harare, Zimbabwe, 3
Department of International Health, Johns Hopkins Bloomberg
School of Public Health, Wolfe Street, Baltimre, MD, 21205
ABSTRACT
The relationship between iron status & HIV infection is
complex & poorly understood. While anemia is a major
complication of HIV infection, higher iron stores may be
associated with disease progression. It is uncertain if
increased iron stores are a cause of disease progression or a
consequence. There is limited & conflicting data available
from Africa, & none that examine this relationship
prospectively. We examined the association between post-partum
iron status & viral load (VL), progression (maternal death by
12 months), & MTCT of HIV in 643 HIV+ Zimbabwean women. In
non-anemic women a log10 increase in SF was associated with a
2.3-fold increase in VL (p=3D0.02); this association was
absent in anemic women. At the same time, Hb was negatively
associated with VL (p<0.01). In prospective analyses, a log10
increase in SF was associated with a 3.5-fold increase in the
risk of death by 12 months (p=3D0.01), but there was no
association with MTCT. Controlling for AGP, a marker of
inflammation, attenuated the association between SF & VL or
progression, but these remained significant. These results are
consistent with the hypothesis that high iron stores have
adverse consequences in HIV infection, however AGP may not
fully control for the effect of HIV on SF (reverse causality).
If adverse consequences are real, our data suggest that they
occur at SF levels > 45 ug/L, and do not include MTCT.
Funding by CIDA, USAID, Nestle, and Cornell Univ
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
<<snip>> associated with a 3.5-fold increase in the risk of
death by 12 months <<snip>>
(The FASEB Journal. 2007;21:673.3) =A9 2007 FASEB ---------
-----------------------------------------------------------
---------=
-----
Serum Ferritin is Associated with HIV Disease Severity &
Mortality among Postpartum Zimbabwean Women Rahul Rawat1, Jean
Humphrey2,3, John Hargrove2, Robert Ntozini2, Kuda Mutasa2,
Peter Iliff2 and Rebecca Stoltzfus1 1 Division of Nutritional
Sciences, Cornell University, Savage Hall, Ithaca, NY, 14853,
2 ZVITAMBO Study Team, 1 Borrowdale Road, Harare, Zimbabwe, 3
Department of International Health, Johns Hopkins Bloomberg
School of Public Health, Wolfe Street, Baltimre, MD, 21205
ABSTRACT
The relationship between iron status & HIV infection is
complex & poorly understood. While anemia is a major
complication of HIV infection, higher iron stores may be
associated with disease progression. It is uncertain if
increased iron stores are a cause of disease progression or a
consequence. There is limited & conflicting data available
from Africa, & none that examine this relationship
prospectively. We examined the association between post-partum
iron status & viral load (VL), progression (maternal death by
12 months), & MTCT of HIV in 643 HIV+ Zimbabwean women. In
non-anemic women a log10 increase in SF was associated with a
2.3-fold increase in VL (p=3D0.02); this association was
absent in anemic women. At the same time, Hb was negatively
associated with VL (p<0.01). In prospective analyses, a log10
increase in SF was associated with a 3.5-fold increase in the
risk of death by 12 months (p=3D0.01), but there was no
association with MTCT. Controlling for AGP, a marker of
inflammation, attenuated the association between SF & VL or
progression, but these remained significant. These results are
consistent with the hypothesis that high iron stores have
adverse consequences in HIV infection, however AGP may not
fully control for the effect of HIV on SF (reverse causality).
If adverse consequences are real, our data suggest that they
occur at SF levels > 45 ug/L, and do not include MTCT.
Funding by CIDA, USAID, Nestle, and Cornell Univ
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk