Ironjustic
Mon, Aug-13-07, 17:16
Journal of Trace Elements in Medicine and Biology
doi:10.1016/j.jtemb.2007.05.002 Copyright =A9 2007 Elsevier
GmbH All rights reserved. Clinical studies
Relationship between indices of iron status and coronary risk
factors including diabetes and the metabolic syndrome in Saudi
subjects without overt coronary disease
Eman M. Alissaa, , , Waqar H. Ahmeda, c, Nabeel Al-amaa, d and
Gordon A=2EA. Fernsb aFaculty of Medicine, King Abdul Aziz
University, P O Box 12713, Jeddah 21483, Saudi Arabia bCentre
for Clinical Science & Measurement, School of Biomedical &
Molecular Science, University of Surrey, Guildford, Surrey GU2
7XH, UK cDepartment of Cardiology, King Fahd Armed Forces
Hospital, Jeddah, Saudi Arabia dDepartment of Medicine, King
Abdul Aziz University Hospital, Jeddah, Saudi Arabia Received
2 December 2006; accepted 22 May 2007. Available online 7
August 2007.
Abstract
There have been inconsistent reports on the relationship
between iron status and coronary artery diseases (CAD), and
little data on this relationship in non-Caucasian populations.
We assessed dietary iron by questionnaire and measured serum
iron and ferritin levels in 270 Saudi male subjects without
established CAD, 130 of whom were angiogram negative. Serum
lipid profile, glucose, high sensitivity-C reactive protein
(hs-CRP), serum soluble intercellular adhesion molecules-1
(sICAM-1), and caeruloplasmin were measured in all subjects.
The angiogram negative patients, had lower serum ferritin
(p<0.05) and iron (p<0.0001) levels than the 140 subjects
without reported cardiovascular diseases (CVD). Serum iron
correlated with serum triglycerides (p<0.0001) and total
cholesterol (p<0.05) levels for this latter group and the
groups combined. Serum ferritin correlated with serum total
cholesterol and low-density lipoprotein (LDL)- cholesterol in
the combined group (p<0.05), and was correlated with blood
glucose and serum LDL-cholesterol (p<0.05) in the subjects
without reported CVD. After adjustment for confounding
variables, serum iron levels remained a significant correlate
with total calorie intake and serum triglycerides. Serum
ferritin also correlated significantly with cholesterol intake
and fasting serum total cholesterol. Dietary iron was
significantly related to dietary cholesterol and fiber, age,
smoking habits, and serum total cholesterol level.
Hence, indices of iron status were related to several coronary
risk factors in the Saudi population.
Keywords: Ferritin; Saudi Arabia; Coronary risk factors;
Metabolic syndrome; Diabetes mellitus
Corresponding author. Tel.: +966 2 66 44444x23432; fax:
+966 2 66 434
99.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
doi:10.1016/j.jtemb.2007.05.002 Copyright =A9 2007 Elsevier
GmbH All rights reserved. Clinical studies
Relationship between indices of iron status and coronary risk
factors including diabetes and the metabolic syndrome in Saudi
subjects without overt coronary disease
Eman M. Alissaa, , , Waqar H. Ahmeda, c, Nabeel Al-amaa, d and
Gordon A=2EA. Fernsb aFaculty of Medicine, King Abdul Aziz
University, P O Box 12713, Jeddah 21483, Saudi Arabia bCentre
for Clinical Science & Measurement, School of Biomedical &
Molecular Science, University of Surrey, Guildford, Surrey GU2
7XH, UK cDepartment of Cardiology, King Fahd Armed Forces
Hospital, Jeddah, Saudi Arabia dDepartment of Medicine, King
Abdul Aziz University Hospital, Jeddah, Saudi Arabia Received
2 December 2006; accepted 22 May 2007. Available online 7
August 2007.
Abstract
There have been inconsistent reports on the relationship
between iron status and coronary artery diseases (CAD), and
little data on this relationship in non-Caucasian populations.
We assessed dietary iron by questionnaire and measured serum
iron and ferritin levels in 270 Saudi male subjects without
established CAD, 130 of whom were angiogram negative. Serum
lipid profile, glucose, high sensitivity-C reactive protein
(hs-CRP), serum soluble intercellular adhesion molecules-1
(sICAM-1), and caeruloplasmin were measured in all subjects.
The angiogram negative patients, had lower serum ferritin
(p<0.05) and iron (p<0.0001) levels than the 140 subjects
without reported cardiovascular diseases (CVD). Serum iron
correlated with serum triglycerides (p<0.0001) and total
cholesterol (p<0.05) levels for this latter group and the
groups combined. Serum ferritin correlated with serum total
cholesterol and low-density lipoprotein (LDL)- cholesterol in
the combined group (p<0.05), and was correlated with blood
glucose and serum LDL-cholesterol (p<0.05) in the subjects
without reported CVD. After adjustment for confounding
variables, serum iron levels remained a significant correlate
with total calorie intake and serum triglycerides. Serum
ferritin also correlated significantly with cholesterol intake
and fasting serum total cholesterol. Dietary iron was
significantly related to dietary cholesterol and fiber, age,
smoking habits, and serum total cholesterol level.
Hence, indices of iron status were related to several coronary
risk factors in the Saudi population.
Keywords: Ferritin; Saudi Arabia; Coronary risk factors;
Metabolic syndrome; Diabetes mellitus
Corresponding author. Tel.: +966 2 66 44444x23432; fax:
+966 2 66 434
99.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk