kebaldwin
Fri, Jul-27-07, 07:38
Researchers from University of Pittsburgh, Department of Epidemiology provide details of new studies and findings in the area of bone research
NewsRx.com
07-26-07
Fresh data on bone research are presented in the report "Inflammatory markers and incident fracture risk in older men and women: the health aging and body composition study. The inflammation of aging hypothesis purports that aging is the accumulation of damage, which results, in part, from chronic activation of inflammation process. We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study," scientists in the United States report.
"Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture. Cytokines play major roles in regulating bone remodeling in the bone microenvironment, but their relationship to fractures is uncertain. The study population includes 2985 well-functioning white and black women and men (42%, black; 51%, women) 70-79 yr of age enrolled in the Health Aging and Body Composition Study. Inflammatory markers were measured in frozen serum using standardized assays. We measured interleukin (IL-6), TNF-alpha, C-reactive protein (CRP), and soluble receptors (IL-2 sR, IL-6 sR, TNF sR1and TNF sR2).Cytokine-soluble receptors were measured in a subset (n30). Total hip BMD was measured by DXA. During 5.8 ??1.6 yr of 95% complete follow-up, incident fractures were confirmed in 268 subjects. The risk of fracture was compared among subjects with the highest inflammatory markers (quartile 4) versus lower levels (quartiles 1, 2, and 3) using proportional hazard models. Subjects who fractured were more likely to be white and female. Baseline markers of inflammation were higher among subjects who subsequently experienced an incident fracture. In multivariate models, the relative risk of fracture (95% CIs) for subjects with the highest inflammatory markers (quartile 4) compared with those with lower inflammatory markers (quartiles 1, 2, and 3) was 1.34 (0.99, 1.82) for CRP; 1.28 (0.95-1.74) for IL-6; 1.28 (0.97-1.70) for TNF-alpha; 1.52 (1.04-2.21) for IL-2 sR; 1.33 (0.90-1.96) for IL-6 sR; 1.73 (1.18-2.55) for TNF sR1 and 1.48 (1.01-2.20) for TNF sR2. In subjects with three or more (out of seven) high inflammatory markers, the relative risk of fracture was 2.65 (1.44-4.89) in comparison with subjects with no elevated markers. (p trend=0.001)," wrote J.A. Cauley and colleagues, University of Pittsburgh, Department of Epidemiology.
The researchers concluded: "We conclude that elevated inflammatory markers are prognostic for fractures, extending the inflammation hypothesis of aging to osteoporotic fractures."
Cauley and colleagues published their study in the Journal of Bone & Mineral Research (Inflammatory markers and incident fracture risk in older men and women: the health aging and body composition study. Journal of Bone & Mineral Research, 2007;22(7):1088-95).
For additional information, contact J.A. Cauley, University of Pittsburgh, Dept. of Epidemiology, Graduate School of Public Health, Pittsburgh, Pennsylvania 15261 USA..
The publisher's contact information for the Journal of Bone & Mineral Research is: American Society Bone & Mineral Research, 2025 M St., N W, Ste. 800, Washington, DC 20036-3309, USA.
Keywords: United States, Pittsburgh, Bone Research, Aging, Bone, Cytokines, Epidemiology.
This article was prepared by Women's Health Law Week editors from staff and other reports. Copyright 2007, Women's Health Law Week via NewsRx.com.
To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .
http://www.lef.org/news/LefDailyNews.htm?NewsID=5647&Section=AGING
NewsRx.com
07-26-07
Fresh data on bone research are presented in the report "Inflammatory markers and incident fracture risk in older men and women: the health aging and body composition study. The inflammation of aging hypothesis purports that aging is the accumulation of damage, which results, in part, from chronic activation of inflammation process. We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study," scientists in the United States report.
"Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture. Cytokines play major roles in regulating bone remodeling in the bone microenvironment, but their relationship to fractures is uncertain. The study population includes 2985 well-functioning white and black women and men (42%, black; 51%, women) 70-79 yr of age enrolled in the Health Aging and Body Composition Study. Inflammatory markers were measured in frozen serum using standardized assays. We measured interleukin (IL-6), TNF-alpha, C-reactive protein (CRP), and soluble receptors (IL-2 sR, IL-6 sR, TNF sR1and TNF sR2).Cytokine-soluble receptors were measured in a subset (n30). Total hip BMD was measured by DXA. During 5.8 ??1.6 yr of 95% complete follow-up, incident fractures were confirmed in 268 subjects. The risk of fracture was compared among subjects with the highest inflammatory markers (quartile 4) versus lower levels (quartiles 1, 2, and 3) using proportional hazard models. Subjects who fractured were more likely to be white and female. Baseline markers of inflammation were higher among subjects who subsequently experienced an incident fracture. In multivariate models, the relative risk of fracture (95% CIs) for subjects with the highest inflammatory markers (quartile 4) compared with those with lower inflammatory markers (quartiles 1, 2, and 3) was 1.34 (0.99, 1.82) for CRP; 1.28 (0.95-1.74) for IL-6; 1.28 (0.97-1.70) for TNF-alpha; 1.52 (1.04-2.21) for IL-2 sR; 1.33 (0.90-1.96) for IL-6 sR; 1.73 (1.18-2.55) for TNF sR1 and 1.48 (1.01-2.20) for TNF sR2. In subjects with three or more (out of seven) high inflammatory markers, the relative risk of fracture was 2.65 (1.44-4.89) in comparison with subjects with no elevated markers. (p trend=0.001)," wrote J.A. Cauley and colleagues, University of Pittsburgh, Department of Epidemiology.
The researchers concluded: "We conclude that elevated inflammatory markers are prognostic for fractures, extending the inflammation hypothesis of aging to osteoporotic fractures."
Cauley and colleagues published their study in the Journal of Bone & Mineral Research (Inflammatory markers and incident fracture risk in older men and women: the health aging and body composition study. Journal of Bone & Mineral Research, 2007;22(7):1088-95).
For additional information, contact J.A. Cauley, University of Pittsburgh, Dept. of Epidemiology, Graduate School of Public Health, Pittsburgh, Pennsylvania 15261 USA..
The publisher's contact information for the Journal of Bone & Mineral Research is: American Society Bone & Mineral Research, 2025 M St., N W, Ste. 800, Washington, DC 20036-3309, USA.
Keywords: United States, Pittsburgh, Bone Research, Aging, Bone, Cytokines, Epidemiology.
This article was prepared by Women's Health Law Week editors from staff and other reports. Copyright 2007, Women's Health Law Week via NewsRx.com.
To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .
http://www.lef.org/news/LefDailyNews.htm?NewsID=5647&Section=AGING