Ironjustic
Sun, Jun-24-07, 17:15
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1574-695X.-
2007.00243.x
FEMS Immunology & Medical Microbiology Volume 50 Issue 1 Page
133-143, June 2007
To cite this article: Luciane Alarc=C3=A3o Dias-Melicio, Sueli
Aparecida Calvi, Ana Paula Bordon, Marjorie A. Golim, Maria
Terezinha Serr=C3=A3o Pera=C3=A7oli, Angela Maria Victoriano
Campos Soares (2007) Chloroquine is therapeutic in murine
experimental model of paracoccidioidomycosis FEMS Immunology &
Medical Microbiology 50 (1), 133=E2=80=93143.
doi:10.1111/j.1574-695X.2007.00243.x
Prev Article Abstract Chloroquine is therapeutic in murine
experimental model of paracoccidioidomycosis Luciane
Alarc=C3=A3o Dias-Melicio11Department of Microbiology and
Immunology, Biosciences Institute, S=C3=A3o Paulo State
University, S=C3=A3o Paulo, Brazil; , Sueli Aparecida
Calvi22Department of Tropical Diseases, School of Medicine,
S=C3=A3o Paulo, Brazil; and , Ana Paula Bordon11Department of
Microbiology and Immunology, Biosciences Institute, S=C3=A3o
Paulo State University, S=C3=A3o Paulo, Brazil; , Marjo= rie
A=2E Golim33Botucatu Blood Center, School of Medicine,
S=C3=A3o Paulo State University, S=C3=A3o Paulo, Brazil, Maria
Terezinha Serr=C3=A3o Pera=C3=A7oli11Department of
Microbiology and Immunology, Biosciences Institute, S=C3=A3o
Paulo State University, S=C3=A3o Paulo, Brazil; & Angela Maria
Victoriano Campos Soares11Department of Microbiology and
Immunology, Biosciences Institute, S=C3=A3o Paulo State
University, S=C3=A3o Paulo, Brazil; 1Department of
Microbiology and Immunology, Biosciences Institute, S=C3=A3o
Paulo State University, S=C3=A3o Paulo, Brazil; 2Depart= ment
of Tropical Diseases, School of Medicine, S=C3=A3o Paulo,
Brazil; and 3Botucatu Blood Center, School of Medicine,
S=C3=A3o Paulo State University, S=C3=A3o Paulo, Brazil
Correspondence: Luciane Alarc=C3=A3o Dias-Melicio, Department
of Microbiology and Immunology, Biosciences Institute,
S=C3=A3o Paulo State University, S=C3=A3o Paulo, Brazil. Tel.:
+55 015 14 3811-6058; fax: +55 015 14 3815-3744; e-mail:
ladiasmelicio@ibb.unesp.br Editor: Alex van Belkum
Abstract
Chloroquine, due to its basic properties, has been shown to
prevent the release of iron from holotransferrin, thereby
interfering with normal iron metabolism in a variety of cell
types. We have studied the effects of chloroquine on the
evolution of experimental paracoccidioidomycosis by evaluating
the viable fungal recovery from lung, liver and spleen from
infected mice and H2O2, NO production, tumor necrosis
factor-alpha (TNF-=CE=B1), interleukin (IL)-6, IL-10 levels
and transferrin receptor (TfR) expression from uninfected and
infected peritoneal macrophages. Chloroquine caused a
significant decrease in the viable fungal recovery from all
organs tested, during all periods of evaluation. Peritoneal
macrophages from chloroquine-treated infected mice showed
higher H2O2 production and TfR expression, and decreased
levels of NO, endogenous and stimulated-TNF-=CE=B1, IL-6 and
IL-10 during the three evaluated periods. However, despite its
suppressor effects on the macrophage function, the chloroquine
therapeutic effect upon murine paracoccidioidomycosis was
probably due to its effect on iron metabolism, blocking iron
uptake by cells, and consequently restricting iron to fungus
growth and survival.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
2007.00243.x
FEMS Immunology & Medical Microbiology Volume 50 Issue 1 Page
133-143, June 2007
To cite this article: Luciane Alarc=C3=A3o Dias-Melicio, Sueli
Aparecida Calvi, Ana Paula Bordon, Marjorie A. Golim, Maria
Terezinha Serr=C3=A3o Pera=C3=A7oli, Angela Maria Victoriano
Campos Soares (2007) Chloroquine is therapeutic in murine
experimental model of paracoccidioidomycosis FEMS Immunology &
Medical Microbiology 50 (1), 133=E2=80=93143.
doi:10.1111/j.1574-695X.2007.00243.x
Prev Article Abstract Chloroquine is therapeutic in murine
experimental model of paracoccidioidomycosis Luciane
Alarc=C3=A3o Dias-Melicio11Department of Microbiology and
Immunology, Biosciences Institute, S=C3=A3o Paulo State
University, S=C3=A3o Paulo, Brazil; , Sueli Aparecida
Calvi22Department of Tropical Diseases, School of Medicine,
S=C3=A3o Paulo, Brazil; and , Ana Paula Bordon11Department of
Microbiology and Immunology, Biosciences Institute, S=C3=A3o
Paulo State University, S=C3=A3o Paulo, Brazil; , Marjo= rie
A=2E Golim33Botucatu Blood Center, School of Medicine,
S=C3=A3o Paulo State University, S=C3=A3o Paulo, Brazil, Maria
Terezinha Serr=C3=A3o Pera=C3=A7oli11Department of
Microbiology and Immunology, Biosciences Institute, S=C3=A3o
Paulo State University, S=C3=A3o Paulo, Brazil; & Angela Maria
Victoriano Campos Soares11Department of Microbiology and
Immunology, Biosciences Institute, S=C3=A3o Paulo State
University, S=C3=A3o Paulo, Brazil; 1Department of
Microbiology and Immunology, Biosciences Institute, S=C3=A3o
Paulo State University, S=C3=A3o Paulo, Brazil; 2Depart= ment
of Tropical Diseases, School of Medicine, S=C3=A3o Paulo,
Brazil; and 3Botucatu Blood Center, School of Medicine,
S=C3=A3o Paulo State University, S=C3=A3o Paulo, Brazil
Correspondence: Luciane Alarc=C3=A3o Dias-Melicio, Department
of Microbiology and Immunology, Biosciences Institute,
S=C3=A3o Paulo State University, S=C3=A3o Paulo, Brazil. Tel.:
+55 015 14 3811-6058; fax: +55 015 14 3815-3744; e-mail:
ladiasmelicio@ibb.unesp.br Editor: Alex van Belkum
Abstract
Chloroquine, due to its basic properties, has been shown to
prevent the release of iron from holotransferrin, thereby
interfering with normal iron metabolism in a variety of cell
types. We have studied the effects of chloroquine on the
evolution of experimental paracoccidioidomycosis by evaluating
the viable fungal recovery from lung, liver and spleen from
infected mice and H2O2, NO production, tumor necrosis
factor-alpha (TNF-=CE=B1), interleukin (IL)-6, IL-10 levels
and transferrin receptor (TfR) expression from uninfected and
infected peritoneal macrophages. Chloroquine caused a
significant decrease in the viable fungal recovery from all
organs tested, during all periods of evaluation. Peritoneal
macrophages from chloroquine-treated infected mice showed
higher H2O2 production and TfR expression, and decreased
levels of NO, endogenous and stimulated-TNF-=CE=B1, IL-6 and
IL-10 during the three evaluated periods. However, despite its
suppressor effects on the macrophage function, the chloroquine
therapeutic effect upon murine paracoccidioidomycosis was
probably due to its effect on iron metabolism, blocking iron
uptake by cells, and consequently restricting iron to fungus
growth and survival.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk