Ironjustic
Thu, May-10-07, 17:15
Osteoporosis Treatment -- Without Estrogen Libraries Medical
News Keywords POSTMENOPAUSAL, OSTEOPOROSIS Contact Information
Available for logged-in reporters only Description
A class of drugs called bisphosphonates has become the new
mainstay treatment for postmenopausal women diagnosed with
osteoporosis in the post-hormone-replacement era. Taking just
one pill a week, or even one a month, may prevent, slow or
stop the breakdown and progress of this bone-thinning
condition, according to the May issue of Mayo Clinic Women's
HealthSource.
Newswise - A class of drugs called bisphosphonates has become
the new mainstay treatment for postmenopausal women diagnosed
with osteoporosis in the post-hormone-replacement era. Taking
just one pill a week, or even one a month, may prevent, slow
or stop the breakdown and progress of this bone-thinning
condition, according to the May issue of Mayo Clinic Women's
HealthSource.
An estimated 10 million Americans, mostly women, have
osteoporosis, where bones become weak and highly prone to
fractures. Millions more have low bone density (osteopenia),
which can increase the risk of fractures.
Bone -- a living tissue -- is constantly remodeling, with old
bone breaking down and new bone replacing it. Bisphosphonates
work by slowing the breakdown and reabsorption of old bone, an
ongoing process that accelerates as estrogen levels fall
during the first few years after menopause. By slowing the
process, bisphosphonates help preserve bone density and reduce
the risk of fractures.
Estrogen once was commonly prescribed to reduce bone loss. But
when the landmark Women's Health Initiative Study, released in
2002, showed that long-term estrogen use increased the risk of
breast cancer, heart attacks, strokes and blood clots, hormone
therapy fell out of favor.
Bisphosphonates have filled the void and perform as well as
estrogen in preventing bone loss. Bisphosphonates available to
treat osteoporosis include alendronate (Fosamax), ibandronate
(Boniva) and risedronate (Actonel).
Patients should talk with a doctor about the best ways to
prevent and treat osteoporosis. Bisphosphonates have
potential side effects, most commonly heartburn and abdominal
pain caused by irritation of the esophagus or stomach. Even
when taking medications, patients should take steps to
protect bones, including consuming adequate calcium and
vitamin D; engaging in regular weight-bearing exercise such
as walking and weight training; and avoiding smoking and
excessive use of alcohol.
--------------------------------------------------------------
--------------=
-----
=A9 2007 Newswise. All Rights Reserved. ----------------------
------------------------------------------------------=
-----
http://tinyurl.com/4ustm
Bisphosphonates
Bisphosphonates are a family of drugs used to prevent and
treat osteoporosis. There are three bisphosphonates currently
approved for use in Canada: alendronate (Fosamax =AE),
etidronate (Didrocal =AE) and risedronate (Actonel =AE).
--------------------------------------------------------------
--------------= =AD----------
<<snip>> Bisphosphonates have antioxidant properties as iron
chelators <<snip>>
Antioxidant effect of bisphosphonates and simvastatin on
chondrocyte lipid peroxidation. Dombrecht EJ, De Tollenaere
CB, Aerts K, Cos P, Schuerwegh AJ, Bridts CH, Van Offel JF,
Ebo DG, Stevens WJ, De Clerck LS Biochem Biophys Res Commun.
2006 Jul 28;
The objective of this study was to evaluate the effect of
bisphosphonates (BPs) and simvastatin on chondrocyte lipid
peroxidation. For this purpose, a flow cytometrical method
using C11-BODIPY(581/591) was developed to detect
hydroperoxide-induced lipid peroxidation in chondrocytes.
Tertiary butylhydroperoxide (t-BHP) induced a time and
concentration dependent increase in chondrocyte lipid
peroxidation. Addition of a Fe(2+)/EDTA complex to t-BHP or
hydrogen peroxide (H(2)O(2)) clearly enhanced lipid
peroxidation. The lipophilic simvastatin demonstrated a small
inhibition in the chondrocyte lipid peroxidation. None of
three tested BPs (clodronate, pamidronate, and risedronate)
had an effect on chondrocyte lipid peroxidation induced by
t-BHP. However, when Fe(2+)/EDTA complex was added to t-BHP or
H(2)O(2), BPs inhibited the lipid peroxidation process varying
from 25% to 58%. This study demonstrates that BPs have
antioxidant properties as iron chelators, thereby inhibiting
the chondrocyte lipid peroxidation. These findings add
evidence to the therapeutic potential of bisphosphonates and
statins in rheumatoid arthritis.
--------------------------------------------------------------
--------------= =AD----------
Age-associated Iron Accumulation in Bone: Implications for
Postmenopausal Osteoporosis and a New Target for Prevention
and Treatment by Chelation. Liu G, Men P, Kenner GH, Miller SC
Biometals. 2006 May 11;
Iron accumulation in tissues is believed to be a
characteristic of aged
humans and a risk factor for some chronic diseases. However,
it is not known whether age-associated iron accumulation is
part of the pathogenesis of postmenopausal osteoporosis that
affects approximately one out three women worldwide. Here, we
confirmed that this accumulation of iron was associated with
osteopenia in ovariectomized (OVX) rats (a model of peri- and
postmenopausal osteoporosis due to estrogen deficiency). To
further investigate whether the increased iron
level plays a causal role in the onset of bone loss, we
treated OVX rats with an orally active and bone targeted
chelator that prevented iron accumulation in their skeletal
tissues. The results showed that this treatment mitigated the
loss of bone mass and the deterioration of
bone micro-architecture. We also found that one possible
mechanism of the protective action of iron chelation was to
significantly reduce bone resorption. Thus, these findings
provide a novel target and a potentially useful therapeutic
strategy for the prevention and treatment of postmenopausal
osteoporosis and perhaps other age- related diseases.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
News Keywords POSTMENOPAUSAL, OSTEOPOROSIS Contact Information
Available for logged-in reporters only Description
A class of drugs called bisphosphonates has become the new
mainstay treatment for postmenopausal women diagnosed with
osteoporosis in the post-hormone-replacement era. Taking just
one pill a week, or even one a month, may prevent, slow or
stop the breakdown and progress of this bone-thinning
condition, according to the May issue of Mayo Clinic Women's
HealthSource.
Newswise - A class of drugs called bisphosphonates has become
the new mainstay treatment for postmenopausal women diagnosed
with osteoporosis in the post-hormone-replacement era. Taking
just one pill a week, or even one a month, may prevent, slow
or stop the breakdown and progress of this bone-thinning
condition, according to the May issue of Mayo Clinic Women's
HealthSource.
An estimated 10 million Americans, mostly women, have
osteoporosis, where bones become weak and highly prone to
fractures. Millions more have low bone density (osteopenia),
which can increase the risk of fractures.
Bone -- a living tissue -- is constantly remodeling, with old
bone breaking down and new bone replacing it. Bisphosphonates
work by slowing the breakdown and reabsorption of old bone, an
ongoing process that accelerates as estrogen levels fall
during the first few years after menopause. By slowing the
process, bisphosphonates help preserve bone density and reduce
the risk of fractures.
Estrogen once was commonly prescribed to reduce bone loss. But
when the landmark Women's Health Initiative Study, released in
2002, showed that long-term estrogen use increased the risk of
breast cancer, heart attacks, strokes and blood clots, hormone
therapy fell out of favor.
Bisphosphonates have filled the void and perform as well as
estrogen in preventing bone loss. Bisphosphonates available to
treat osteoporosis include alendronate (Fosamax), ibandronate
(Boniva) and risedronate (Actonel).
Patients should talk with a doctor about the best ways to
prevent and treat osteoporosis. Bisphosphonates have
potential side effects, most commonly heartburn and abdominal
pain caused by irritation of the esophagus or stomach. Even
when taking medications, patients should take steps to
protect bones, including consuming adequate calcium and
vitamin D; engaging in regular weight-bearing exercise such
as walking and weight training; and avoiding smoking and
excessive use of alcohol.
--------------------------------------------------------------
--------------=
-----
=A9 2007 Newswise. All Rights Reserved. ----------------------
------------------------------------------------------=
-----
http://tinyurl.com/4ustm
Bisphosphonates
Bisphosphonates are a family of drugs used to prevent and
treat osteoporosis. There are three bisphosphonates currently
approved for use in Canada: alendronate (Fosamax =AE),
etidronate (Didrocal =AE) and risedronate (Actonel =AE).
--------------------------------------------------------------
--------------= =AD----------
<<snip>> Bisphosphonates have antioxidant properties as iron
chelators <<snip>>
Antioxidant effect of bisphosphonates and simvastatin on
chondrocyte lipid peroxidation. Dombrecht EJ, De Tollenaere
CB, Aerts K, Cos P, Schuerwegh AJ, Bridts CH, Van Offel JF,
Ebo DG, Stevens WJ, De Clerck LS Biochem Biophys Res Commun.
2006 Jul 28;
The objective of this study was to evaluate the effect of
bisphosphonates (BPs) and simvastatin on chondrocyte lipid
peroxidation. For this purpose, a flow cytometrical method
using C11-BODIPY(581/591) was developed to detect
hydroperoxide-induced lipid peroxidation in chondrocytes.
Tertiary butylhydroperoxide (t-BHP) induced a time and
concentration dependent increase in chondrocyte lipid
peroxidation. Addition of a Fe(2+)/EDTA complex to t-BHP or
hydrogen peroxide (H(2)O(2)) clearly enhanced lipid
peroxidation. The lipophilic simvastatin demonstrated a small
inhibition in the chondrocyte lipid peroxidation. None of
three tested BPs (clodronate, pamidronate, and risedronate)
had an effect on chondrocyte lipid peroxidation induced by
t-BHP. However, when Fe(2+)/EDTA complex was added to t-BHP or
H(2)O(2), BPs inhibited the lipid peroxidation process varying
from 25% to 58%. This study demonstrates that BPs have
antioxidant properties as iron chelators, thereby inhibiting
the chondrocyte lipid peroxidation. These findings add
evidence to the therapeutic potential of bisphosphonates and
statins in rheumatoid arthritis.
--------------------------------------------------------------
--------------= =AD----------
Age-associated Iron Accumulation in Bone: Implications for
Postmenopausal Osteoporosis and a New Target for Prevention
and Treatment by Chelation. Liu G, Men P, Kenner GH, Miller SC
Biometals. 2006 May 11;
Iron accumulation in tissues is believed to be a
characteristic of aged
humans and a risk factor for some chronic diseases. However,
it is not known whether age-associated iron accumulation is
part of the pathogenesis of postmenopausal osteoporosis that
affects approximately one out three women worldwide. Here, we
confirmed that this accumulation of iron was associated with
osteopenia in ovariectomized (OVX) rats (a model of peri- and
postmenopausal osteoporosis due to estrogen deficiency). To
further investigate whether the increased iron
level plays a causal role in the onset of bone loss, we
treated OVX rats with an orally active and bone targeted
chelator that prevented iron accumulation in their skeletal
tissues. The results showed that this treatment mitigated the
loss of bone mass and the deterioration of
bone micro-architecture. We also found that one possible
mechanism of the protective action of iron chelation was to
significantly reduce bone resorption. Thus, these findings
provide a novel target and a potentially useful therapeutic
strategy for the prevention and treatment of postmenopausal
osteoporosis and perhaps other age- related diseases.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk