Ironjustic
Sat, May-05-07, 17:15
Clin Gastroenterol Hepatol. 2007 May;5(5):624-9. Relationship
between transferrin-iron saturation, alcohol consumption, and
the incidence of cirrhosis and liver cancer. Ioannou GN, Weiss
NS, Kowdley KV. Division of Gastroenterology, Department of
Medicine, Veterans Affairs Puget Sound Health Care System,
University of Washington, Seattle, Washington; University of
Washington Medical Center, University of Washington, Seattle,
Washington.
Background & Aims: Excessive alcohol consumption and iron
overload might act in synergy to promote hepatic fibrogenesis
and carcinogenesis. We examined the relation between baseline
serum transferrin-iron saturation (TS) and the incidence of
hospitalizations or deaths related to cirrhosis and liver
cancer as well as the influence of alcohol consumption on this
relationship. Methods: Participants included 8767 persons aged
25-74 years without evidence of cirrhosis at entry into the
study or during the first 5 years of follow-up who were
subsequently followed for a mean of 13.3 years as part of the
first National Health and Nutrition Examination Survey.
Results: During 116,656 person-years of follow-up, 115
participants were hospitalized for or died of cirrhosis and 4
more of liver cancer. Compared with persons with low TS (<40%)
and low alcohol consumption (</=1 drink/day) who had an
incidence of cirrhosis/liver cancer of
70/100,000 person-years, the incidence was increased in
persons with elevated TS (>/=40%) and low alcohol
consumption (154/100,000; adjusted hazard ratio, 2.2; 95%
confidence interval, 1.3-3.8) and in persons with low TS
and elevated (>1 drink/day) alcohol consumption
(71/100,000; adjusted hazard ratio, 2.9; 95% confidence
interval,
72.7-5.0). The incidence of cirrhosis/liver cancer was
particularly high among persons with both elevated TS and
elevated alcohol consumption (480/100,000; adjusted hazard
ratio, 6.8; 95% confidence interval, 3.6-12.9), exceeding
the rate predicted by the addition of the separate
attributable risks associated with drinking and elevated
serum TS. Conclusions: Elevated serum TS is associated with
an increased incidence of cirrhosis or liver cancer
particularly in the presence of elevated alcohol
consumption.
PMID: 17478349 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
between transferrin-iron saturation, alcohol consumption, and
the incidence of cirrhosis and liver cancer. Ioannou GN, Weiss
NS, Kowdley KV. Division of Gastroenterology, Department of
Medicine, Veterans Affairs Puget Sound Health Care System,
University of Washington, Seattle, Washington; University of
Washington Medical Center, University of Washington, Seattle,
Washington.
Background & Aims: Excessive alcohol consumption and iron
overload might act in synergy to promote hepatic fibrogenesis
and carcinogenesis. We examined the relation between baseline
serum transferrin-iron saturation (TS) and the incidence of
hospitalizations or deaths related to cirrhosis and liver
cancer as well as the influence of alcohol consumption on this
relationship. Methods: Participants included 8767 persons aged
25-74 years without evidence of cirrhosis at entry into the
study or during the first 5 years of follow-up who were
subsequently followed for a mean of 13.3 years as part of the
first National Health and Nutrition Examination Survey.
Results: During 116,656 person-years of follow-up, 115
participants were hospitalized for or died of cirrhosis and 4
more of liver cancer. Compared with persons with low TS (<40%)
and low alcohol consumption (</=1 drink/day) who had an
incidence of cirrhosis/liver cancer of
70/100,000 person-years, the incidence was increased in
persons with elevated TS (>/=40%) and low alcohol
consumption (154/100,000; adjusted hazard ratio, 2.2; 95%
confidence interval, 1.3-3.8) and in persons with low TS
and elevated (>1 drink/day) alcohol consumption
(71/100,000; adjusted hazard ratio, 2.9; 95% confidence
interval,
72.7-5.0). The incidence of cirrhosis/liver cancer was
particularly high among persons with both elevated TS and
elevated alcohol consumption (480/100,000; adjusted hazard
ratio, 6.8; 95% confidence interval, 3.6-12.9), exceeding
the rate predicted by the addition of the separate
attributable risks associated with drinking and elevated
serum TS. Conclusions: Elevated serum TS is associated with
an increased incidence of cirrhosis or liver cancer
particularly in the presence of elevated alcohol
consumption.
PMID: 17478349 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk