dina1957
Wed, Mar-28-07, 14:05
Study Reveals Missing Link Between Pre-Diabetes & Type 2 Diabetes
New research suggests a �missing link� between the pre-diabetes state and the clinical diagnosis of type 2 diabetes mellitus.
Both impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are intermediate states in the transition from normal glucose tolerance (NGT) toT2DM and have been termed as “pre-diabetes”. They are associated with a high risk for progression to T2DM.
Hepatic glucose production (HGP) is the principal determinant of fasting plasma glucose (FPG). In the current study, the authors have demonstrated that, in the non-diabetic range, the rise in fasting plasma glucose (FPG) concentration is associated with a mild decrease in hepatic glucose production (HGP) and a marked decrease in the glucose clearance rate.
“During the fasting state, the decrease in glucose clearance results in an increase in FPG concentration which stimulates basal insulin secretion. The rise in fasting plasma insulin concentration, in turn, inhibits HGP, thus attenuating the rise in FPG,” Rucha Jani, MD, the study’s author said. “The high fasting blood glucose in these subjects can thus be explained by the decrease in glucose clearance. This is an important observation as it provides insight into the pathogenic mechanisms that characterize the ‘pre-diabetic’ stage.”
“Pinpointing the missing link is quite important,” Dr. Jani said. “It allows us to identify potential future targets in order to develop effective therapies to prevent the progression from pre-diabetes to type 2 diabetes.”
These new findings will be presented at the American Association of Clinical Endocrinologists (AACE) Sixteenth Annual Meeting and Clinical Congress which will be held April 11 – April 15 at the Washington State Convention & Trade Center in Seattle. Dr. Jani will be in the Media Room to discuss these findings on Friday, April 13, from 9:00 a.m. to 10:30 a.m.
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FACT:
Charleston, WV, is the market with the highest incidence of people who purchased medicine for diabetes over the past year. Scarborough Research, the leading local market research firm for identifying consumer and retail behaviors in the United States, finds that Fifteen percent of consumers in this market are diabetes medication purchasers*. Knoxville, TN (14 percent), Memphis, TN (11 percent), Columbus, OH (11 percent), and Tulsa, OK (11 percent) round out the top local markets for diabetes medication purchasers. Eight percent of all consumers nationally purchased medication for this disease. The Scarborough analysis also finds that Walgreens is the number one national drug store brand among diabetes medication purchasers. More than 3.1 million, or 18 percent, of these consumers purchased prescription drugs at Walgreens during the past year. CVS (17 percent), Wal-Mart (16 percent), Rite Aid (8 percent), and Eckerd Drug (4 percent) complete the top national drug store brands among diabetes medication purchasers. In Charleston, Wal-Mart is the top store among diabetes medication purchasers, as over one-quarter (27 percent) of these consumers purchased prescription drugs there during the past year. Rite-Aid (20 percent), CVS (14 percent), Fruth Pharmacy (8 percent), and Kroger (5 percent) are other leading stores among diabetes medication purchasers.
This article came from
http://www.diabetesincontrol.com/results.php?storyarticle=4660
Please visit Diabetes In Control for the most current news in Diabetes care.
www.diabetesincontrol.com (http://www.diabetesincontrol.com)
http://www.diabetesincontrol.com/results_print.php?storyarticle=4660
New research suggests a �missing link� between the pre-diabetes state and the clinical diagnosis of type 2 diabetes mellitus.
Both impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are intermediate states in the transition from normal glucose tolerance (NGT) toT2DM and have been termed as “pre-diabetes”. They are associated with a high risk for progression to T2DM.
Hepatic glucose production (HGP) is the principal determinant of fasting plasma glucose (FPG). In the current study, the authors have demonstrated that, in the non-diabetic range, the rise in fasting plasma glucose (FPG) concentration is associated with a mild decrease in hepatic glucose production (HGP) and a marked decrease in the glucose clearance rate.
“During the fasting state, the decrease in glucose clearance results in an increase in FPG concentration which stimulates basal insulin secretion. The rise in fasting plasma insulin concentration, in turn, inhibits HGP, thus attenuating the rise in FPG,” Rucha Jani, MD, the study’s author said. “The high fasting blood glucose in these subjects can thus be explained by the decrease in glucose clearance. This is an important observation as it provides insight into the pathogenic mechanisms that characterize the ‘pre-diabetic’ stage.”
“Pinpointing the missing link is quite important,” Dr. Jani said. “It allows us to identify potential future targets in order to develop effective therapies to prevent the progression from pre-diabetes to type 2 diabetes.”
These new findings will be presented at the American Association of Clinical Endocrinologists (AACE) Sixteenth Annual Meeting and Clinical Congress which will be held April 11 – April 15 at the Washington State Convention & Trade Center in Seattle. Dr. Jani will be in the Media Room to discuss these findings on Friday, April 13, from 9:00 a.m. to 10:30 a.m.
================================
FACT:
Charleston, WV, is the market with the highest incidence of people who purchased medicine for diabetes over the past year. Scarborough Research, the leading local market research firm for identifying consumer and retail behaviors in the United States, finds that Fifteen percent of consumers in this market are diabetes medication purchasers*. Knoxville, TN (14 percent), Memphis, TN (11 percent), Columbus, OH (11 percent), and Tulsa, OK (11 percent) round out the top local markets for diabetes medication purchasers. Eight percent of all consumers nationally purchased medication for this disease. The Scarborough analysis also finds that Walgreens is the number one national drug store brand among diabetes medication purchasers. More than 3.1 million, or 18 percent, of these consumers purchased prescription drugs at Walgreens during the past year. CVS (17 percent), Wal-Mart (16 percent), Rite Aid (8 percent), and Eckerd Drug (4 percent) complete the top national drug store brands among diabetes medication purchasers. In Charleston, Wal-Mart is the top store among diabetes medication purchasers, as over one-quarter (27 percent) of these consumers purchased prescription drugs there during the past year. Rite-Aid (20 percent), CVS (14 percent), Fruth Pharmacy (8 percent), and Kroger (5 percent) are other leading stores among diabetes medication purchasers.
This article came from
http://www.diabetesincontrol.com/results.php?storyarticle=4660
Please visit Diabetes In Control for the most current news in Diabetes care.
www.diabetesincontrol.com (http://www.diabetesincontrol.com)
http://www.diabetesincontrol.com/results_print.php?storyarticle=4660